RNAi in murine hepatocytes: the agony of choice—a study of the influence of lipid-based transfection reagents on hepatocyte metabolism

Archives of Toxicology

Volumn 89, Issue 9, 2015, Pages 1579-1588

  Böttger, Jan ^a   Arnold, Katrin ^a   Thiel, Carlo ^a   Rennert, Christiane ^a   Aleithe, Susanne ^a   Hofmann, Ute ^b   Vlaic, Sebastian ^c   Sales, Susanne ^d   Shevchenko, Andrej ^d   Matz Soja, Madlen ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c HANS KNÖLL INSTITUTE   (Germany)

^d MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

Hepatocytes; HiPerFect ; In vitro; INTERFERin ; Lipofectamine RNAiMAX; Non viral siRNA transfection

Indexed keywords

AMINO ACID; APC PROTEIN; CHOLESTEROL ESTER; FAT DROPLET; LIPIDOME; LIPOFECTAMINE; LIVER X RECEPTOR ALPHA; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMALL INTERFERING RNA; SMOOTHENED PROTEIN; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; TRIACYLGLYCEROL; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; LIPID;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL METABOLISM; CELL VIABILITY; CELL VIABILITY ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; IN VITRO STUDY; LIPID LIVER LEVEL; LIPID METABOLISM; LIPOSOMAL GENE DELIVERY SYSTEM; LIVER CELL; LIVER METABOLISM; MALE; MASS FRAGMENTOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; METABOLISM;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION REGULATION; HEPATOCYTES; INDICATORS AND REAGENTS; LIPIDS; MALE; MICE; MICE, INBRED C57BL; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84940598426     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1571-0     Document Type: Article

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