Modulating secretory pathway pH by proton channel co-expression can increase recombinant protein stability in plants

Biotechnology Journal

Volumn 10, Issue 9, 2015, Pages 1478-1486

  Jutras, Philippe V ^a   D'Aoust, Marc André ^b   Couture, Manon M J ^b   Vézina, Louis Philippe ^b,d   Goulet, Marie Claire ^a   Michaud, Dominique ^a   Sainsbury, Frank ^a,c  

^a UNIVERSITÉ LAVAL   (Canada)

^b Medicago Inc   (Canada)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d Groupe TH Inc   (Canada)

Author keywords

Influenza M2; Intracellular pH; Ion channel expression; Recombinant hemagglutinin; Transient expression

Indexed keywords

CELL ENGINEERING; IONS; PEPTIDES; PH EFFECTS; PLANTS (BOTANY); PROTEINS;

INFLUENZA M2; INTRACELLULAR PH; ION CHANNEL; RECOMBINANT HEMAGGLUTININ; TRANSIENT EXPRESSION;

RECOMBINANT PROTEINS;

INFLUENZA VIRUS HEMAGGLUTININ; PROTEIN M2; RECOMBINANT PROTEIN; ION CHANNEL; MATRIX PROTEIN;

ACIDITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GOLGI COMPLEX; HETEROLOGOUS EXPRESSION; NICOTIANA BENTHAMIANA; NONHUMAN; PH; PLANT CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN QUALITY; PROTEIN STABILITY; SECRETORY CELL; SECRETORY PATHWAY; STABLE EXPRESSION; SYNTHETIC BIOLOGY; TRANSIENT EXPRESSION; BIOTECHNOLOGY; CHEMISTRY; GENETICS; METABOLISM; SECRETION (PROCESS); TOBACCO;

BIOTECHNOLOGY; HYDROGEN-ION CONCENTRATION; ION CHANNELS; PROTEIN STABILITY; RECOMBINANT PROTEINS; TOBACCO; VIRAL MATRIX PROTEINS;

EID: 84940583123     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201500056     Document Type: Article

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