Increased Acid Stability of the Hemagglutinin Protein Enhances H5N1 Influenza Virus Growth in the Upper Respiratory Tract but Is Insufficient for Transmission in Ferrets

Journal of Virology

Volumn 87, Issue 17, 2013, Pages 9911-9922

  Zaraket, Hassan ^a   Bridges, Olga A ^a   Duan, Susu ^a   Baranovich, Tatiana ^a   Yoon, Sun Woo ^a   Reed, Mark L ^a   Salomon, Rachelle ^a,c   Webby, Richard J ^a,b   Webster, Robert G ^a   Russell, Charles J ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CELL PH; CELL SPECIFICITY; CONTROLLED STUDY; DUCK; ENDOSOME; EPITHELIUM CELL; FEMALE; FERRET; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; LUNG ALVEOLUS CELL; MDCK CELL; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; NOSE CAVITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN INDUCTION; PROTEIN STABILITY; RECEPTOR BINDING; STRAIN DIFFERENCE; UPPER RESPIRATORY TRACT; VIROGENESIS; VIRUS ENTRY; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSMISSION; VIRUS VIRULENCE; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; DOGS; FERRETS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HOST SPECIFICITY; HUMANS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS, H5N1 SUBTYPE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; ORTHOMYXOVIRIDAE INFECTIONS; PROTEIN CONFORMATION; PROTEIN STABILITY; RESPIRATORY SYSTEM; VIRULENCE; VIRUS INTERNALIZATION;

EID: 84883308224     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01175-13     Document Type: Article

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