The zinc transporter Slc30a8/ZnT8 is required in a subpopulation of pancreatic α;-cells for hypoglycemia-induced glucagon secretion

Journal of Biological Chemistry

Volumn 290, Issue 35, 2015, Pages 21432-21442

  Solomou, Antonia ^a   Meur, Gargi ^a   Bellomo, Elisa ^a,e   Hodson, David J ^a   Tomas, Alejandra ^a,b   Li, Stéphanie Migrenne ^c   Philippe, Erwann ^c   Herrera, Pedro L ^d   Magnan, Christophe ^c   Rutter, Guy A ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITY OF GENEVA   (Switzerland)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELLS; GLUCOSE; INSULIN; MAMMALS; PHYSIOLOGY; ZINC;

CONTROL-CELL; CRE RECOMBINASE; GLUCAGON SECRETION; INTRACELLULAR CA; PANCREATIC ISLET; SECRETORY GRANULES; ZINC ACCUMULATION; ZINC TRANSPORTERS;

CYTOLOGY;

CALCIUM ION; GLUCAGON; GLUCOSE; INSULIN; PROTEIN ZNT8; UNCLASSIFIED DRUG; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; ZINC; ZINC TRANSPORTER ZNT8, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL SUBPOPULATION; CONTROLLED STUDY; EXON; FEMALE; HORMONE RELEASE; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENE DELETION; GENETICS; INSULIN RESISTANCE; METABOLISM;

ANIMALS; CATION TRANSPORT PROTEINS; CELLS, CULTURED; FEMALE; GENE DELETION; GLUCAGON; GLUCAGON-SECRETING CELLS; GLUCOSE; HYPOGLYCEMIA; INSULIN RESISTANCE; MICE, INBRED C57BL; ZINC;

EID: 84940528708     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.645291     Document Type: Article

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