The molecular clock as a metabolic rheostat

Diabetes, Obesity and Metabolism

Volumn 17, Issue S1, 2015, Pages 99-105

  Perelis, M ^a   Ramsey, K M ^a   Bass, J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Circadian clock; Glucose homeostasis; Metabolism; Pancreatic islet; Transcription regulation

Indexed keywords

INSULIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN; TRANSCRIPTION FACTOR ARNTL; GLUCOSE;

AGING; CELL FUNCTION; DIET RESTRICTION; ENERGY TRANSFER; EPIGENETICS; FEEDING BEHAVIOR; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RELEASE; METABOLIC REGULATION; METABOLISM; MOLECULAR CLOCK; NONHUMAN; NUTRIENT; OXIDATION; OXIDATIVE STRESS; REVIEW; SLEEP WAKING CYCLE; ANIMAL; CIRCADIAN RHYTHM; EATING; ENERGY METABOLISM; HOMEOSTASIS; MOUSE; OXIDATION REDUCTION REACTION; PANCREAS ISLET; PHOTOPERIODICITY; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ANIMALS; CIRCADIAN CLOCKS; EATING; ENERGY METABOLISM; FASTING; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; OXIDATION-REDUCTION; PHOTOPERIOD; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84940512415     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12521     Document Type: Review

References (58)

1. Lowrey PL, Takahashi JS. Genetics of the mammalian circadian system: photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu Rev Genet 2000; 34: 533-562.
2. Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science 2010; 330: 1349-1354.
3. Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol 2010; 72: 517-549.
4. Balsalobre A, Damiola F, Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 1998; 93: 929-937.
5. Lamia KA, Storch KF, Weitz CJ. Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A 2008; 105: 15172-15177.
6. Peek CB, Affinati AH, Ramsey KM et al. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science 2013; 342: 1243417.
7. Marcheva B, Ramsey KM, Buhr ED et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 2010; 466: 571-572.
8. Sadacca LA, Lamia KA, deLemos AS, Blum B, Weitz CJ. An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia 2011; 54: 120-124.
9. Doherty CJ, Kay SA. Circadian control of global gene expression patterns. Annu Rev Genet 2010; 44: 419-444.
10. Johnson CH, Golden SS, Kondo T. Adaptive significance of circadian programs in cyanobacteria. Trends Microbiol 1998; 6: 407-410.
11. Ouyang Y, Andersson CR, Kondo T, Golden SS, Johnson CH. Resonating circadian clocks enhance fitness in cyanobacteria. Proc Natl Acad Sci U S A 1998; 95: 8660-8664.
12. Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 2009; 41: 89-94.
13. Dupuis J, Langenberg C, Prokopenko I et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010; 42: 105-116.
14. Mulder H, Nagorny CL, Lyssenko V, Groop L. Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene. Diabetologia 2009; 52: 1240-1249.
15. Chang AM, Aeschbach D, Duffy JF, Czeisler CA. Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proc Natl Acad Sci U S A 2015; 112: 1232-1237.
16. Gekakis N, Staknis D, Nguyen HB et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science 1998; 280: 1564-1569.
17. Turek FW, Joshu C, Kohsaka A et al. Obesity and metabolic syndrome in circadian clock mutant mice. Science 2005; 308: 1043-1045.
18. Maury E, Hong HK, Bass J. Circadian disruption in the pathogenesis of metabolic syndrome. Diabetes Metab 2014; 40: 338-346.
19. Everett LJ, Lazar MA. Nuclear receptor Rev-erbalpha: up, down, and all around. Trends Endocrinol Metab 2014; 25: 586-592.
20. Asher G, Schibler U. Crosstalk between components of circadian and metabolic cycles in mammals. Cell Metab 2011; 13: 125-137.
21. Lee J, Moulik M, Fang Z et al. Bmal1 and beta-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced beta-cell failure in mice. Mol Cell Biol 2013; 33: 2327-2338.
22. Pulimeno P, Mannic T, Sage D et al. Autonomous and self-sustained circadian oscillators displayed in human islet cells. Diabetologia 2013; 56: 497-507.
23. Koike N, Yoo SH, Huang HC et al. Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science 2012; 338: 349-354.
24. Menet JS, Rodriguez J, Abruzzi KC, Rosbash M. Nascent-Seq reveals novel features of mouse circadian transcriptional regulation. eLife 2012; 1: e00011.
25. Fang B, Everett LJ, Jager J et al. Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. Cell 2014; 159: 1140-1152.
26. Bell GI, Polonsky KS. Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 2001; 414: 788-791.
27. Gaulton KJ, Nammo T, Pasquali L et al. A map of open chromatin in human pancreatic islets. Nat Genet 2010; 42: 255-259.
28. Kameswaran V, Bramswig NC, McKenna LB et al. Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metab 2014; 19: 135-145.
29. Pasquali L, Gaulton KJ, Rodriguez-Segui SA et al. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Nat Genet 2014; 46: 136-143.
30. Froy O. Circadian rhythms, aging, and life span in mammals. Physiology (Bethesda) 2011; 26: 225-235.
31. Panda S, Antoch MP, Miller BH et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 2002; 109: 307-320.
32. Akhtar RA, Reddy AB, Maywood ES et al. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol 2002; 12: 540-550.
33. Storch KF, Lipan O, Leykin I et al. Extensive and divergent circadian gene expression in liver and heart. Nature 2002; 417: 78-83.
34. Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci U S A 2014; 111: 16219-16224.
35. Ramsey KM, Yoshino J, Brace CS et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 2009; 324: 651-654.
36. Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 2009; 324: 654-657.
37. Asher G, Gatfield D, Stratmann M et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 2008; 134: 317-328.
38. Nakahata Y, Kaluzova M, Grimaldi B et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 2008; 134: 329-340.
39. Revollo JR, Korner A, Mills KF et al. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 2007; 6: 363-375.
40. Sasaki Y, Vohra BP, Lund FE, Milbrandt J. Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide. J Neurosci 2009; 29: 5525-5535.
41. Wang G, Han T, Nijhawan D et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 2014; 158: 1324-1334.
42. Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 2004; 305: 1010-1013.
43. Ramsey KM, Mills KF, Satoh A, Imai S. Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging Cell 2008; 7: 78-88.
44. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab 2011; 14: 528-536.
45. Canto C, Houtkooper RH, Pirinen E et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 2012; 15: 838-847.
46. Chang HC, Guarente L. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 2013; 153: 1448-1460.
47. Hirschey MD, Shimazu T, Goetzman E et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010; 464: 121-125.
48. Dyar KA, Ciciliot S, Wright LE et al. Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock. Mol Metab 2014; 3: 29-41.
49. Damiola F, Le Minh N, Preitner N et al. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 2000; 14: 2950-2961.
50. Stokkan KA, Yamazaki S, Tei H, Sakaki Y, Menaker M. Entrainment of the circadian clock in the liver by feeding. Science 2001; 291: 490-493.
51. Kohsaka A, Laposky AD, Ramsey KM et al. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab 2007; 6: 414-421.
52. Arble DM, Bass J, Laposky AD, Vitaterna MH, Turek FW. Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring) 2009; 17: 2100-2102.
53. Hatori M, Vollmers C, Zarrinpar A et al. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab 2012; 15: 848-860.
54. Stunkard A, Lu XY. Rapid changes in night eating: considering mechanisms. Eat Weight Disord 2010; 15: e2-e8.
55. Maury E, Ramsey KM, Bass J. Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ Res 2010; 106: 447-462.
56. Cho H, Zhao X, Hatori M et al. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 2012; 485: 123-127.
57. Feng D, Liu T, Sun Z et al. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 2011; 331: 1315-1319.
58. Rey G, Cesbron F, Rougemont J et al. Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol 2011; 9: e1000595.