The atherogenicity of plant sterols: The evidence from genetics to clinical trials

Journal of AOAC International

Volumn 98, Issue 3, 2015, Pages 742-749

  Weingärtner, Oliver ^a   Teupser, Daniel ^b   Patel, Shailendra B ^c,d  

^a UNIVERSITY OF OLDENBURG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; LIPIDS; MEDICAL APPLICATIONS; MOLECULES;

CARDIOVASCULAR RISK; CLINICAL TRIAL; ESSENTIAL NUTRIENTS; GENETIC DISRUPTION; INTESTINAL ABSORPTION; PAUCITY OF DATA; PLANT STEROLS; PLASMA CHOLESTEROL;

ALCOHOLS;

PHYTOSTEROL;

ANIMAL; ATHEROSCLEROSIS; CHEMICALLY INDUCED; CHEMISTRY; CLINICAL TRIAL (TOPIC); COMPLICATION; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ENTEROPATHY; GENETICS; HUMAN; HYPERCHOLESTEROLEMIA; PLANT;

ANIMALS; ATHEROSCLEROSIS; CLINICAL TRIALS AS TOPIC; HUMANS; HYPERCHOLESTEROLEMIA; INTESTINAL DISEASES; LIPID METABOLISM, INBORN ERRORS; PHYTOSTEROLS; PLANTS;

EID: 84940476719     PISSN: 10603271     EISSN: None     Source Type: Journal    
DOI: 10.5740/jaoacint.SGEWeingartner     Document Type: Article

References (91)

1. The Global Burden of Disease 2004 Update, World Health Organization. http://www.who.int/mediacentre/factsheets/fs310/en/index.html (accessed October 4, 2014)
2. Weingärtner, O., & Laufs, U. (2006) Hamostaseologie 26, 158-166
3. Estruch, R., Ros, E., Salas-Salvado, J., Covas, M.I., Corella, D., Aros, F., Gomez-Gracia, E., Ruiz-Gutierrez, V., Fiol, M., Lapetra, J., Lamuela-Reventos, R.M., Serra-Majem, L., Pinto, X., Basora, J., Munoz, M.A., Sorli, J.V., Martinez, J.A., & Martinez-Gonzales, M.A. (2013) New Engl. J. Med. 368, 1279-1290. http://dx.doi.org/10.1056/NEJMoa1200303
4. Baigent, C., Keech, A., Kearney, P.M., Blackwell, L., Buck, G., Pollicino, C., Kirby, A., Sourjina, T., Peto, R., Collins, R., & Simes, R. (2005) Lancet 366, 1267-1278.
5. Expert Panel on Detection E (2001) Treatment of High Blood Cholesterol in A. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III), J. Amer. Med. Assoc. 285, 2486-2497. http://dx.doi.org/10.1001/jama.285.19.2486
6. Stone, N.J., Robinson, J.G., Lichtenstein, A.H., Bairey Merz, C.N., Blum, C.B., Eckel, R.H., Goldberg, A.C., Gordon, D., Levy, D., Lloyd-Jones, D.M., McBride, P., Schwartz, J.S., Shero, S.T., Smith, S.C., Jr, Watson, K., Wilson, P.W., Eddleman, K.M., Jarrett, N.M., LaBresh, K., Nevo, L., Wnek, J., Anderson, J.L., Halperin, J.L., Albert, N.M., Bozkurt, B., Brindis, R.G., Curtis, L.H., BeMets, D., Hochmann, J.S., Kovacs, R.J., Ohman, E.M., Pressler, S.J., Sellke, S.W., Shen, W.K., Smith, S.C., Jr, & Tomaselli, G.F. (2014) Circulation 129 (25 Suppl 2), S1-S45. http://dx.doi.org/10.1161/01.cir.0000437738.63853.7a
7. Weingärtner, O., Böhm, M., & Laufs, U. (2009) Eur. Heart J. 30, 404-409. http://dx.doi.org/10.1093/eurheartj/ehn580
8. Weingärtner, O., Baber, R., & Teupser D. (2014) Biochem. Biophys. Res. Co. 446, 811-813. http://dx.doi.org/10.1016/j.bbrc.2014.01.147
9. Brendsel, J., & Green, S.J. (2007) Atherosclerosis 192, 227-229. http://dx.doi.org/10.1016/j.atherosclerosis.2006.08.019
10. Weingärtner, O., Böhm, M., & Laufs, U. (2011) J. Amer. Med. Assoc. 306, 2217-2218. http://dx.doi.org/10.1001/jama.2011.1719
11. Sudhop, T., Gottwald, B.M., & von Bergmann, K. (2002) Metabolis. 51, 1519-1521. http://dx.doi.org/10.1053/meta.2002.36298
12. Patel, M.D., & Thompson, P.D. (2006) Atherosclerosis 186, 12-19. http://dx.doi.org/10.1016/j.atherosclerosis.2005.10.026
13. Gylling, H., Plat, J., Turley, S., Ginsberg, H.N., Ellegard, L., Jessup, W., Jones, J.P., Lütjohann, D., März, W., Masana, L., Silbernagel, G., Staels, B., Boren, J., Catapano, A.L., BeBacker, D., Deanfield, J., Descamps, O.S., Kovanen, P.T., Riccardi, G., Tökgezoglu, L., & Chapmann, M.J. (2014) Atherosclerosis 232, 346-360. http://dx.doi.org/10.1016/j.atherosclerosis.2013.11.043
14. Schoenheimer, R. (1929) Hoppe-Seyler's Z. für Physiol Chem. 180, 1-5. http://dx.doi.org/10.1515/bchm2.1929.180.1-3.1
15. Pollack, O.J. (1953) Circulation 7, 703-706
16. Best, M.M., Duncan, C.H., VanLoon, E.J., & Wathen, J.D. (1954) Circulation 10, 201-206. http://dx.doi.org/10.1161/01.CIR.10.2.201
17. Bhattacharyya, A.K., Connor, W.E., & Spector, A.A. (1972) J. Clin. Invest. 51, 2060-2070. http://dx.doi.org/10.1172/JCI107012
18. Salen, G., Horak, I., Rothkopf, M., Cohen, J.L., Speck, J., Tint, G.S., Shore, V., Dayal, B., Chen, T., & Shefer, S. (1985) J. Lipid Res. 26, 1126-1133
19. Beaty, T.H., Kwiterovich, P., Jr, Khoury, M.J., White, S., Bachorik, P.S., Smith, H.H., Teng, B., & Sniderman, A. (1986) Amer. J. Hum. Genet. 38, 492-504
20. Berger, G.M., Pegoraro, R.J., Patel, S.B., Naidu, P., Rom, L., Hidaka, H., Marais, A.D., Jadhav, A., Naoumova, R.P., & Thompson, G.R. (1998) J. Lipid Res. 39, 1046-1054
21. Patel, S.B., Honda, A., & Salen, G. (1998) J. Lipid Res. 39, 1055-1061
22. Patel, S.B., Salen, G., Hidaka, H., Kwiterovich, P.O., Stalenhoef, A.F., Miettinen, T.A., Grundy, S.M., Lee, M.H., Rubenstein, J.P., Polymeroopoulus, M.H., & Brownstein, M.J. (1998) J. Clin. Invest. 102, 1041-1044. http://dx.doi.org/10.1172/JCI3963
23. Lee, M.-H., Gordon, D., Ott, J., Lu, K., Ose, L., Miettinen, T., Gylling, H., Stalenhoef, A.F., Pandya, A., Hidaka, H., Brewer, B., Jr, Kojima, H., Sakuma, N., Pegoraro, R., Salen, G., & Patel, S.B. (2001) Eur. Hum. Genet. 9, 375-384. http://dx.doi.org/10.1038/sj.ejhg.5200628
24. Berge, K.E., Tian, H., Graf, G.A., Yu, L., Grishin, N.V., Schultz, J., Kwiterovich P., Shan, B., Barnes, R., & Hobbs, H.H. (2000) Science 290, 1771-1775. http://dx.doi.org/10.1126/science.290.5497.1771
25. Lee, M.-H., Lu, K., Hazard, S., Yu, H., Shulenin, S., Hidaka, H., Kojima, H., Allikmets, R., Sakuma, N., Pegoraro, R., Srivastava, A.K., Salen, G., Dean, M., & Patel, S.B. (2001) Nat. Gen. 27, 79-83. http://dx.doi.org/10.1038/87170
26. Patel, S.B., & Salen, G. (2010) in Evidence-Based Management of Lipid Disorders, M.N. Vissers, J.J.P. Kastelein, & E.S. Stroes (Eds) TFM Publishing Ltd, Harley Shrewsbury, UK, pp 217-230
27. Hazard, S.E., & Patel, S.B. (2007) Pflugers Arch. 453, 745-752. http://dx.doi.org/10.1007/s00424-005-0040-7
28. Salen, G., Shefer, S., Nguyen, L., Ness, G.C., Tint, G.S., & Shore, V. (1992) J. Lipid Res. 33, 945-955
29. Kolovou, G., Voudris, V., Drogari, E., Palatianos, G., & Cokkinos, D.V. (1996) Eur. Heart J. 17, 965-966. http://eurheartj.oxfordjournals.org/content/17/6/965
30. Mymin, D., Wang, J., Frohlich, J., & Hegele, R.A. (2003) Circulation 107, 791. http://dx.doi.org/10.1161/01.CIR.0000050545.21826.AD
31. Yu, L., Hammer, R.E., Li-Hawkins, J., Von Bergmann, K., Lütjohann, D., Cohen, J.C., & Hobbs, H.H. (2002) Proc. Natl. Acad. Sci. USA 99, 16237-16242. http://dx.doi.org/10.1073/pnas.252582399
32. Klett, E.L., Lu, K., Kosters, A., Vink, E., Lee, M.H., Altenburg, M., Shefer, S., Batta, A.K. Yu, H., Chen, J., Klein, R., Looije, N., Oude-Elferink, R., Groen, A.K., Maeda, N., Salan, G., & Patel, S.B. (2004) BMC Med. 2, 5. http://dx.doi.org/10.1186/1741-7015-2-5
33. Plosch, T., Bloks, V.W., Terasawa, Y., Berdy, S., Siegler, K., Van Der Sluijs, F., Kema, I.P., Groen, A.K., Shan, B., & Schwartz, M. (2004) Gastroenterology 126, 290-300. http://dx.doi.org/10.1053/j.gastro.2003.10.074
34. Hansel, B., Carrie, A., Brun-Druc, N., Leclert, G., Chantepie, S., Coiffard, A, S., Kahn, J.F., Chapman, M.J., & Bruckert, E. (2014) Atherosclerosis 234, 162-168. http://dx.doi.org/10.1016/j.atherosclerosis.2014.02.030
35. Salen, G., von Bergmann, K., Lütjohann, D., Kwiterovich, P., Kane, J., Patel, S.B., Musliner, T., Stein, P., & Musser, B. (2004) Circulation 109, 966-971. http://dx.doi.org/10.1161/01.CIR.0000116766.31036.03
36. Musliner, T., Cselovszky, D., Sirah, W., McCrary Sisk, C., Sapre, A., Salen, G., Lütjohann, D., & Bergmann, K. (2008) Int. J. Clin. Pract. 62, 995-1000. http://dx.doi.org/10.1111/j.1742-1241.2008.01786.x
37. Lütjohann, D., von Bergmann, K., Sirah, W., Macdonell, G., Johnson-Levonas, A.O., Shah, A., Lütjohann, D., Lin, J., Sapre, A., & Musliner, T. (2008) Int. J. Clin. Pract. 62, 1499-1510. http://dx.doi.org/10.1111/j.1742-1241.2008.01841.x
38. Solca, C., Stanga, Z., Pandit, B., Diem, P., Greeve, J., & Patel, S.B. (2005) Clin. Genet. 68, 174-178
39. Bhattacharyya, A.K., & Connor, W.E. (1974) J. Clin Invest. 53, 1033-1043
40. Yu, L., von Bergmann, K., Lütjohann, D., Hobbs, H.H., & Cohen, J.C. (2004) J. Lipid Res. 45, 301-307. http://dx.doi.org/10.1194/jlr.M300377-JLR200
41. Weihrauch, J.L., & Gardner, J.M. (1978) J. Am. Diet. Assoc. 73, 39-47
42. Mellies, M.J., Ishikawa, T.T., Glueck, C.J., Bove, K., & Morrison, J. (1976) J. Lab. Clin. Med. 88, 914-921
43. Helske, S., Miettinen, T., Gylling, H., Mayranpaa, M., Lommi, J., Turto, H., Werkkala, K., Kupari, M., & Kovanen, P.T. (2008) J. Lipid Res. 49, 1511-1518. http://dx.doi.org/10.1194/jlr.M800058-JLR200
44. Rees, D.C., Iolascon, A., Carella, M., O'Marcaigh, A.S., Kendra, J.R., Jowitt, S.N., Wales, J.K., Vora, A., Makris, M., Manning, N., Nicolaou, A., Fisher, J., Mann, A., Machin, S.J., Clayton, P.T., Gasparini, P., & Stewart, G.W. (2005) Brit. J. Haematol. 130, 297-309. http://dx.doi.org/10.1111/j.1365-2141.2005.05599.x
45. Patel, S.B. (2014) Curr. Opin Lipidol. 25, 169-175. http://dx.doi.org/10.1097/MOL.0000000000000071
46. Vanmierlo, T., Popp, J., Kolsch, H., Friedrichs, S., Jessen, F., Stoffel-Wagner, B., Bertsch, T., Hartmann, T., Maier, W., von Bergmann, K., Steinbusch, H., Mulder, M., & Lütjohann, D. (2011) Acta Psychiatr. Scand. 124, 184-192. http://dx.doi.org/10.1111/j.1600-0447.2011.01713.x
47. Vanmierlo, T., Rutten, K., van Vark-van der Zee, L.C., Friedrichs, S., Bloks, V.W., Blokland, A., Ramaekers, F.C., Sijbrands, E., Steinbusch, H., Prickaerts, J., Kuipers, F., Lütjohann, D., & Mulder, M. (2011) Plant Foods Hum. Nutr. 66, 149-156. http://dx.doi.org/10.1007/s11130-011-0219-3
48. Tansley, G., Holmes, D.T., Lütjohann, D., Head, E., & Wellington, C.L. (2012) Curr. Gerontol. Geriatr. Res. article ID 179318. http://dx.doi.org/10.1155/2012/179318
49. Vanmierlo, T., Weingärtner, O., van der Pol, S., Husche, C., Kerksiek, A., Friedrichs, S., Sijbrands, E., Steinbusch, H., Grimm, M., Hartmann, T., Laufs, U., Böhm, M., de Vries, H.E., Mulder, M., & Lütjohann, D. (2012) J. Lipid Res. 53, 726-735. http://dx.doi.org/10.1194/jlr.M017244
50. Ras, R.T., Hiemstra, H., Lin, Y., Vermeer, M.A., Duchateau, G.S., & Trautwein, E.A. (2013) Atherosclerosis 230, 336-346. http://dx.doi.org/10.1194/jlr.P000471
51. Glueck, C.J., Speirs, J., Tracy, T., Streicher, P., Illig, E., Vandegrift, J. (1991) Metabolis. 40, 842- 848. http://dx.doi.org/10.1016/0026-0495(91)90013-M
52. Rajaratnam, R.A., Gylling, H., & Miettinen, T.A. (2000) J. Am. Coll. Cardiol. 35, 1185-1191
53. Assmann, G., Cullen, P., Erbey, J., Ramey, D.R., Kannenberg, F., & Schulte, H. (2006) Nutr. Metab. Cardiovas. 16, 13-21. http://dx.doi.org/10.1016/j.numecd.2005.04.001
54. Weingärtner, O., Weingärtner, N., Scheller, B., Lütjohann, D., Gräber, S., Schäfers, H.J., Böhm, M., & Laufs, U. (2009) Coronary Artery Dis. 20, 376-382. http://dx.doi.org/10.1097/MCA.0b013e32832fa947
55. Weingärtner, O., Lütjohann, D., Vanmierlo, T., Muller, S., Günther, L., Herrmann, W., Böhm, M., Laufs, U., & Herrmann, M. (2011) Chem. Phys. Lipids 164, 451-456. http://dx.doi.org/10.1016/j.chemphyslip.2011.03.008
56. Matthan, N.R., Pencina, M., LaRocque, J.M., Jacques, P.F., D'Agostino, R.B., Schaefer, E.J., & Lichtenstein, A.H. (2009) J. Lipid Res. 50, 1927-1935. http://dx.doi.org/10.1194/jlr.P900039-JLR200
57. Silbernagel, G., Fauler, G., Hoffmann, M.M., Lütjohann, D., Winkelmann, B.R., Boehm, B.O., & Maerz, W. (2010) J. Lipid Res. 51, 2384-2393. http://dx.doi.org/10.1194/jlr.P002899
58. Silbernagel, G., Fauler, G., Renner, W., Landl, E.M., Hoffmann, M.M., Winkelmann, B.R., Boehm, B.O., & Marz, W. (2009) J. Lipid Res. 50, 334-341. http://dx.doi.org/10.1194/jlr.P800013-JLR200
59. Miettinen, T.A., Gylling, H., Strandberg, T., & Sarna, S. (1998) Brit. J. Med. 316, 1127-1130. http://dx.doi.org/10.1136/bmj.316.7138.1127
60. Wilund, K.R., Yu, L., Xu, F., Vega, G.L., Grundy, S.M., Cohen, J.C., & Hobbs, H.H. (2004) Arteriosclerosis Throm. Vas. 24, 2326-2332
61. Pinedo, S., Vissers, M.N., von Bergmann, K., Elharchaoui, K., Lütjohann, D., Luben, R., Wareham, N.J., Kastelein, J.J., Khaw, K.T., & Boekholdt, S.M. (2007) J. Lipid Res. 48, 139-144. http://dx.doi.org/10.1194/jlr.M600371-JLR200
62. Fassbender, K., Lütjohann, D., Dik, M.G., Bremmer, M., Konig, J., Walter, S., Liu, Y., Letiémbre, M., von Bergmann, K., & Jonker, C. (2008) Atherosclerosis 196, 283-288. http://dx.doi.org/10.1016/j.atherosclerosis.2006.10.032
63. Escurriol, V., Cofan, M., Moreno-Iribas, C., Larranaga, N., Martinez, C., Navarro, C., Rodríguez, L., González, C.A., Corella, D., & Ros, E. (2010) J. Lipid Res. 51, 618-624
64. Genser, B., Silbernagel, G., De Backer, G., Bruckert, E., Carmena, R., Chapman, M.J., Deanfield, J., Descamps, O.S., Rietzschel, E.R., Dias, K.C., & März, W. (2012) Eur. Heart J. 33, 444-451. http://dx.doi.org/10.1093/eurheartj/ehr441
65. Weingärtner, O., Björkhem, I., & Lütjohann, D. (2014) J. Am. Coll. Cardiol. 63, 695-696
66. Thiery, J., Ceglarek, U., Fiedler, G.M., Leichtle, A., Baumann, S., Teupser, D., Lang, O., Baumert, J., Meisinger, C., Loewel, H., & Doering, A. (2006) Circulation 114:II-884
67. Miettinen, T.A., Gylling, H., Hallikainen, M., Juonala, M., Rasanen, L., Viikari, J., & Raitakari, O.T. (2010) Atherosclerosis 209, 592-597. http://dx.doi.org/10.1016/j.atherosclerosis.2009.10.013
68. Weingärtner, O., Pinsdorf, T., Rogacev, K.S., Blömer, L., Grenner, Y., Gräber, S., Ulrich, C., Girndt, M., Böhm, M., Fliser, D., Laufs, U., Lütjohann, D., & Heine, G.H. (2010) PloS One 5, e13467
69. Jansen, H., Samani, N.J., & Schunkert, H. (2014) Eur. Heart J. 35, 1917-1924. http://dx.doi.org/10.1093/eurheartj/ehu208
70. Elliott, P., Chambers, J.C., Zhang, W., Clarke, R., Hopewell, J.C., Peden, J.F., Erdmann, J., Braund, P., Engert, J.C., Bennett, D., Coin, L., Ashby, D., Tzoulaki, I., Brown, I.J., Mt-Isa, S., McCarthy, M.I., Peltonen, L., Freimer, N.B., Farrall, M., Ruokonen, A., Hamsten, A., Lim, N., Froguel, P., Waterworth, D.M., Vollenweider, P., Waeber, G., Jarvelin, M.R., Mooser, V., Scott, J., Hall, A.S., Schunkert, H., Anand, S.S., Collins, R., Samani, N.J., Watkins, H., & Kooner, J.S. (2009) J. Amer. Med. Assoc. 302, 37-48. http://dx.doi.org/10.1001/jama.2009.954
71. Teupser, D., Baber, R., Ceglarek, U., Scholz, M., Illig, T., Gieger, C., Holdt, L.M., Leichtle, A., Greiser, K.H., Huster, D., Linsel-Nitschke, P., Schäfer, A., Braund, P.S., Tiret, L., Stark, K., Raaz-Schrauder, D., Fiedler, G.M., Wilfert, W., Beutner, F., gielen, S., Grosshenning, A., König, I.R., Lichtner, P., Heid, I.M., Kluttig, A., El Mokhtarri, N.E., Rubin, D., Ekici, A.B., Peis, A., Garlichs, C.D., Hall, A.S., Matthes, G., Wittekind, C., Hengstenberg, C., Cambien, F., Schreiber, S., Werdan, K., Meitinger, T., Loeffler, M., Samani, N.J., Erdmann, J., Wichmann, H.E., Schunkert, H., & Thiery, J. (2010) Circ. Cardiovasc. Genet. 3, 331-339. http://dx.doi.org/10.1161/CIRCGENETICS.109.907873
72. Consortium, I.K.C. (2011) PLoS Genet. 7, e1002260. http://dx.doi.org/10.1371/journal.pgen.1002260
73. Reilly, M.P., Li, M., He, J., Ferguson, J.F., Stylianou, I.M., Mehta, N.N., Burnett, M.S., Devaney, J.M., Knouff, C.W., Thompson, J.R., Horne, B.D., Stewert, A.F., Assimes, T.L., Wild, P.S., Allayee, H., Nitschke, P.L., Patel, R.S., Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium, Martinelli, N., Girelli, D., Quyyumi, A.A., Anderson, J.L., Erdmann, J., Hall, A.S., Schnkert, H., Quertermous, T., Blankenberg, S., Hazen, S.L., Roberts, R., Kathiresan, S., Samani, N.J., Epstein, S.E., & Radner, D.J. (2011) Lancet 377, 383-392. http://dx.doi.org/10.1016/S0140-6736(10)61996-4
74. Consortium, C.A.D., Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T.L., Thompson, J.R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B.A., Stirrups, K., Köning, I.R., Cazier, J.B., johansson, A., Hall, A.S., Lee, J.Y., Willer, C.J., Chambers, J.C., Esko, T., Folkersen, L., Lyytikäinen, L.P., Rafelt, S., Shungin, D., Strawbridge, R.J., Thorleifsson, G., Tikkanen, E., Van Zuydam, N., Voight, B.F., Waite, L.L., Zhang, W., Ziegler, A., Absher, D., Altshuler, D., Balmforth, A.J., Barroso, I., Braund, P.S., Burgdorf, C., Claudi-Boem, S., Cox, D., Dimitriou, M., Do, R.; DIAGRAM Consortium; CARDIOGENICS Consortium, Doney, A.S., El Mokhtari, N., Eriksson, P., Fischer, K., Fontanillas, P., Franco-Cereceda, A., Gigante, B., Groop, L., Gustafsson, S., Hager, J., Hallmans, G., Han, B.G., Hunt, S.E., Kang, H.M., Illig, T., Kessler, T., Knowles, J.W., Kolovou, G., Kuusisto, J., Langenberg, C., Langford, C., Leander, K., Lokki, M.L., Lundmark, A., McCarthy, M.I., Meisinger, C., Melander, O., Mihailov, E., Maouche, S., Morris, A.D., Müller-Nurasyid, M.; MuTHER Consortium, Nikus, K., Peden, J.F., Rayner, N.W., Rasheed, A., Rosinger, S., Rubin, D., Rumpf, M.P., Schäfer, A., Sivanathan, M., Song, C., Stewert, A.F., Tan, S.T., Thorgeirsson, G., van der Schoot, C.E., Wagner, P.J.; Wellcome Trust Case Control Consortium, Wells, G.A., Wild, P.S., Yang, T.P., Amouyel, P., Arveiler, D., Basart, H., Boehnke, M., Boerwinkle, E., Brambilla, P., Cambien, F., Cupples, A.L., de Faire, U., Dehghan, A., Diemert, P., Epstein, S.E., Evans, A., Ferrario, M.M., Ferriéres, J., Gauguier, D., Go, A.S., Goodall, A.H., Gudnason, V., Hazen, S.L., Holm, H., Iribarren, C., Jang, Y., Kähönen, M., Kee, F., Kim, H.S., Klopp, N., Köenig, W., Kratzer, W., Kuulasmaa, K., Laakso, M., Laaksonen, R., Lee, J.Y., Lind, L., Ouwehand, W.H., Parish, S., Park, J.E., Pedersen, N.L., Peters, A., Quertermous, T., Radner, D.J., Salomaa, V., Schadt, E., Shah, S.H., Sinisalo, J., Stark, K., Stefansson, K., Trégouët, D.A., Virtamo, J., Wallentin, L., Wareham, N., Zimmermann, M.E., Nieminen, M.S., Hengstenberg, C., Sandhu, M.S., Pastinen, T., Syvänen, A.C., Hovingh, G.K., Dedoussis, G., Franks, P.W., Lehtimäki, T., Metspalu, A., Zalloua, P.A., Siegbahn, A., Schreiber, S., Ripatti, S., Blankenberg, S.S., Perola, M., Clarke, R., Boehm, B.O., O'Donnell, C., Reilly, M.P., März, W., Collins, R., Kathiresan, S., Hamsten, A., Kooner, J.S., Thorsteinsdottir, U., Danesh, J., Palmer, C.N., Roberts, R., Watkins, H., Schunkert, H., & Samani, N.J. (2013) Nat. Genet. 45, 25-33
75. Silbernagel, G., Chapman, M.J., Genser, B., Kleber, M.E., Fauler, G., & Scharnagl, H. (2013) J. Am. Coll. Cardiol. 62, 291-299. http://dx.doi.org/10.1016/j.jacc.2013.01.100
76. Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Z., & Verschuren, M. (2012) Eur. Heart J. 33, 1635-1701. http://dx.doi.org/10.1093/eurheartj/ehs092
77. European Association for Cardiovascular P, Rehabilitation, Reiner, Z., Catapano, A.L., De Backer, G., & Graham, I. (2011) Eur. Heart J. 32, 1769-1818
78. Anderson, T.J., Boden, W.E., Desvigne-Nickens, P., Fleg, J.L., Kashyap, M.L., McBride, R., & Probstfield, J.L. (2014) New Engl. J. Med. 371, 288-290. http://dx.doi.org/10.1056/NEJMc1311039
79. Lloyd-Jones, D.M. (2014) New Engl. J. Med. 371, 271-273. http://dx.doi.org/10.1056/NEJMe1406410
80. Demonty, I., Ras, R.T., van der Knaap, H.C., Duchateau, G.S., Meijer, L., Zock, P.L., Geleijinse, J.M., & Trautwein, E.A. (2009) J. Nutr. 139, 271-284. http://dx.doi.org/10.3945/jn.108.095125
81. Bresson, J.-L., Flynn, A., Heinonen, M., Hulshof, K., Korhonen, H., Lagiou, P., Løvik, M., Marchelli, R., Martin, A., Moseley, B., Palou, A., Przyrembel, H., Salminen, S., Strain, S.J.J., Strobel, S., Tetens, I., van den Berg, H., van Loveren H., & Verhagen, H. (2008) The EFSA J. 781, 1-12
82. Plat, J., MacKay, D., Baumgartner, S., Clifton, P.M., Gylling, H., & Jones, P.J. (2012) Atherosclerosis 225, 521-533. http://dx.doi.org/10.1016/j.atherosclerosis.2012.09.018
83. Ratnayake, W.M., L'Abbe, M.R., Mueller, R., Hayward, S., Plouffe, L., Hollywood, R., (2000) J. Nutr. 130, 1166-1178
84. Meng, C.Q. (2001) Curr. Opin. Invest. Drugs 2, 389-392
85. Weingärtner, O., Lütjohann, D., Ji, S., Weisshoff, N., List, F., Sudhop, T., von Bergmann, K., Gertz, K., König, J., Schäfers, H.J., Endres, M., Böhm, M., & Laufs, U. (2008) J. Am. Coll. Cardiol. 51, 1553-1561. http://dx.doi.org/10.1016/j.jacc.2007.09.074
86. Weingärtner, O., Ulrich, C., Lütjohann, D., Ismail, K., Schirmer, S.H., Vanmierlo, T., Böhm, M., & Laufs, U. (2011) Cardiovasc. Res. 90, 484-492. http://dx.doi.org/10.1093/cvr/cvr020
87. Moghadasian, M.H., McManus, B.M., Pritchard, P.H., & Frohlich, J.J. (1997) Arterioscl. Throm. Vas. 17, 119-126
88. Plat, J., Beugels, I., Gijbels, M.J., de Winther, M.P., & Mensink, R.P. (2006) J. Lipid Res. 47, 2762-2771. http://dx.doi.org/10.1194/jlr.M600346-JLR200
89. Plat, J., Theuwissen, E., Husche, C., Lütjohann, D., Gijbels, M.J., Jeurissen, M., Shiri-Sverdlov, R., van der Made, I., & Mensink, R.P. (2014) Brit. J. Nutr. 111, 64-70. http://dx.doi.org/10.1017/S0007114513002018
90. Solca, C., Tint, G.S., & Patel, S.B. (2013) J. Lipid Res. 54, 397-409. http://dx.doi.org/10.1194/jlr.M031476
91. McDaniel, A.L., Alger, H.M., Sawyer, J.K., Kelley, K.L., Kock, N.D., Brown, J.M., Temel, R.E., & Rudel, L.L. (2013) Am. J. Pathol. 182, 1131-1138. http://dx.doi.org/10.1016/j.ajpath.2012.12.014