Oxidised plant sterols as well as oxycholesterol increase the proportion of severe atherosclerotic lesions in female LDL receptor+/- mice

British Journal of Nutrition

Volumn 111, Issue 1, 2014, Pages 64-70

  Plat, Jogchum ^a   Theuwissen, Elke ^a   Husche, Constanze ^b   Lütjohann, Dieter ^b   Gijbels, Marion J J ^a   Jeurissen, Mike ^a   Shiri Sverdlov, Ronit ^a   Van Der Made, Ingeborg ^a   Mensink, Ronald P ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Atherosclerosis; Diets; Lipoproteins; Oxyphytosterols; Oxysterols

Indexed keywords

CHOLESTEROL; COLLAGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; OXYCHOLESTEROL; OXYPHYTOSTEROL DERIVATIVE; PHYTOSTEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 17ALPHA CAMPESTEROL; 17ALPHA SITOSTEROL; 17BETA CAMPESTEROL; 17BETA SITOSTEROL; 17KETO CAMPESTEROL; 17KETO SITOSTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD SAMPLING; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIETARY INTAKE; DISEASE SEVERITY; EXPOSURE; FEEDING; FEMALE; HETEROZYGOSITY; LIPID DIET; MACROPHAGE; MOUSE; NONHUMAN; ANIMAL CELL; CELL COUNT; LIPOPROTEIN BLOOD LEVEL; PROTEIN BLOOD LEVEL;

ANIMALS; CHOLESTEROL, DIETARY; DIET, HIGH-FAT; FEMALE; LIPID PEROXIDATION; MICE; MICE, INBRED STRAINS; OXIDATION-REDUCTION; PHYTOSTEROLS; PLAQUE, ATHEROSCLEROTIC; RECEPTORS, LDL;

EID: 84891811095     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114513002018     Document Type: Article

References (27)

1. Katan MB, Grundy SM, Jones P, et al. (2003) Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78, 965-978.
2. Normen L, Johnsson M, Andersson H, et al. (1999) Plant ster-ols in vegetables and fruits commonly consumed in Sweden. Eur J Nutr 38, 84-89.
3. Grandgirard A, Martine L, Joffre C, et al. (2004) Gas chroma-tographic separation and mass spectrometric identification of mixtures of oxyphytosterol and oxycholesterol derivatives application to a phytosterol-enriched food. J Chromatogr A 1040, 239-250.
4. Plat J, Brzezinka H, Lutjohann D, et al. (2001) Oxidized plant sterols in human serum and lipid infusions as measured by combined gas-liquid chromatography-mass spectrometry. J Lipid Res 42, 2030-2038.
5. Grandgirard A, Martine L, Demaison L, et al. (2004) Oxyphy-tosterols are present in plasma of healthy human subjects. Br J Nutr 91, 101-106.
6. Husche C, Weingärtner O, Pettersson H, et al. (2011) Validation of an isotope dilution gas chromatography-mass spectrometry method for analysis of 7-oxygenated campes-terol and sitosterol in human serum. Chem Phys Lipids 164, 425-431.
7. Szuchman A, Aviram M, Musa R, et al. (2008) Characterization of oxidative stress in blood from diabetic vs. hypercholestero-laemic patients, using a novel synthesized marker. Biomarkers 13, 119-131.
8. Rimner A, Al Makdessi S, Sweidan H, et al. (2005) Relevance and mechanism of oxysterol stereospecifity in coronary artery disease. Free Radic Biol Med 38, 535-544.
9. Staprans I, Pan XM, Rapp JH, et al. (1998) Oxidized cholesterol in the diet accelerates the development of aortic atherosclerosis in cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol 18, 977-983.
10. Tomoyori H, Kawata Y, Higuchi T, et al. (2004) Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but do not accelerate atherosclerosis in apolipopro-tein E-deficient mice. J Nutr 134, 1690-1696.
11. Adcox C, Boyd L, Oehrl L, et al. (2001) Comparative effects of phytosterol oxides and cholesterol oxides in cultured macrophage-derived cell lines. J Agric Food Chem 49, 2090-2095.
12. Liang YT, Wong WT, Guan L, et al. (2011) Effect of phytos-terols and their oxidation products on lipoprotein profiles and vascular function in hamster fed a high cholesterol diet. Atherosclerosis 219, 124-133.
13. Plat J, Beugels I, Gijbels MJ, et al. (2006) Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols. J Lipid Res 47, 2762-2771.
14. Goossens P, Gijbels MJJ, Zernecke A, et al. (2010) Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab 12, 142-153.
15. Ando M, Tomoyori H & Imaizumi K (2002) Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. Br J Nutr 88, 339-345.
16. Sevanian A, Hodis HN, Hwang J, et al. (1995) Characterization of endothelial cell injury by cholesterol oxidation products found in oxidized LDL. J Lipid Res 36, 1971-1986.
17. Clare K, Hardwick SJ, Carpenter KL, et al. (1995) Toxicity of oxysterolstohuman monocyte-macrophages. Atherosclerosis 118, 67-75.
18. Peng SK, Tham P, Taylor CB, et al. (1979) Cytotoxicity of oxidation derivatives of cholesterol on cultured aortic smooth muscle cells and their effect on cholesterol biosynthesis. Am J Clin Nutr 32, 1033-1042.
19. Christ M, Luu B, Mejia JE, et al. (1993) Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymo-cytes. Immunology 78, 455-460.
20. Vejux A & Lizard G (2009) Cytotoxic effects of oxysterols associated with human diseases: induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis. Mol Aspects Med 30, 153-170.
21. Brown AJ & Jessup W (1999) Oxysterols and atherosclerosis. Atherosclerosis 142, 1-28.
22. Turchetto E, Lercker G & Bortolomeazzi R (1993) Oxysterol determination in selected coffees. Toxicol Ind Health 9, 519-527.
23. Dutta PC (1997) Studies on phytosterol oxides. II: content in some vegetable oils and in French fries prepared in these oils. J Am Oil Chem Soc 74, 659-666.
24. Zunin P, Calcagno C & Evangelisti F (1998) Sterol oxidation in infant milk formulas and milk cereals. J Dairy Res 65, 591-598.
25. Dutta PC (1997) Studies on phytosterol oxides. I: effect of storage on the content in potato chips prepared in different vegetable oils. J Am Oil Chem Soc 74, 647-657.
26. 2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7b-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol. J Biol Chem 270, 20278-20284.
27. O'Callaghan YC, Foley DA, O'Connell NM, et al. (2010) Cyto-toxic and apoptotic effects of the oxidized derivatives of stigmasterol in the U937 human monocytic cell line. J Agric Food Chem 58, 10793-10798.