Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments

FASEB Journal

Volumn 29, Issue 8, 2015, Pages 3582-3592

  Karunadharma, Pabalu P ^a,c   Basisty, Nathan ^a   Chiao, Ying Ann ^a   Dai, Dao Fu ^a   Drake, Rachel ^a   Levy, Nick ^a   Koh, William J ^a   Emond, Mary J ^a   Kruse, Shane ^b   Marcinek, David ^b   Maccoss, Michael J ^a   Rabinovitch, Peter S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Aging; Caloric restriction; Mitochondria; Proteostasis; Rapamycin

Indexed keywords

ADENOSINE TRIPHOSPHATE; DEUTERIUM; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEOME; RAPAMYCIN; STABLE ISOTOPE; UBIQUITIN; PROTEIN; PROTEIN SUBUNIT;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIVER; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN METABOLISM; PROTEIN SUBUNIT; PROTEIN SYNTHESIS; RESPIRATORY CHAIN; TANDEM MASS SPECTROMETRY; UBIQUITINATION; ANIMAL; C57BL MOUSE; ELECTRON TRANSPORT; EVOLUTION; FEMALE; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; PROCEDURES;

MUS;

ANIMALS; BIOLOGICAL EVOLUTION; CALORIC RESTRICTION; ELECTRON TRANSPORT; FEMALE; ISOTOPE LABELING; LEUCINE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MITOCHONDRIA; PROTEIN SUBUNITS; PROTEINS; PROTEOLYSIS; UBIQUITINATION;

EID: 84940421896     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-272666     Document Type: Article

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