Fluorescent gold nanoclusters: Synthesis and recent biological application

Journal of Nanomaterials

Volumn 2015, Issue , 2015, Pages

  Qu, Xiaochao ^a   Li, Yichen ^a   Li, Lei ^a   Wang, Yanran ^a   Liang, Jingning ^a   Liang, Jimin ^a  

^a XIDIAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; FLUORESCENCE; GOLD; METAL NANOPARTICLES; NANOPARTICLES;

BIOLOGICAL APPLICATIONS; BIOLOGICAL SENSING; CONTROLLABLE SYNTHESIS; FERMI WAVELENGTH; SINGLE METAL ATOMS; SURFACE FUNCTIONALIZATION; SYNTHESIS STRATEGY; SYNTHETIC METHODS;

NANOCLUSTERS;

EID: 84940416914     PISSN: 16874110     EISSN: 16874129     Source Type: Journal    
DOI: 10.1155/2015/784097     Document Type: Article

References (186)

1. E. C. Dreaden, A. M. Alkilany, X. Huang, C. J. Murphy, and M. A. El-Sayed, "The golden age: gold nanoparticles for biomedicine," Chemical Society Reviews, vol. 41, no. 7, pp. 2740-2779, 2012.
2. M. C. Roco, "Nanotechnology: convergence with modern biology and medicine," Current Opinion in Biotechnology, vol. 14, no. 3, pp. 337-346, 2003.
3. L. Shang, S. Dong, and G. U. Nienhaus, "Ultra-small fuorescent metal nanoclusters: synthesis and biological applications," Nano Today, vol. 6, no. 4, pp. 401-418, 2011.
4. M.-C. Daniel and D. Astruc, "Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnol-ogy," Chemical Reviews, vol. 104, no. 1, pp. 293-346, 2004.
5. Z. Wu and R. Jin, "On the ligands role in the fuorescence of gold nanoclusters," Nano Letters, vol. 10, no. 7, pp. 2568-2573, 2010.
6. R. Jin, "Quantum sized, thiolate-protected gold nanoclusters," Nanoscale, vol. 2, no. 3, pp. 343-362, 2010.
7. Q. Zhang, J. Xie, Y. Yu, and J. Y Lee, "Monodispersity control in the synthesis of monometallic and bimetallic quasi-spherical gold and silver nanoparticles," Nanoscale, vol. 2, no. 10, pp. 1962-1975, 2010.
8. L. Zhang and E. Wang, "Metal nanoclusters: new fuorescent probes for sensors and bioimaging," Nano Today, vol. 9, no. 1, pp. 132-157, 2014.
9. J. Zheng, C. W. Zhang, and R. M. Dickson, "Highly fuorescent, water-soluble, size-tunable gold quantum dots," Physical Review Letters, vol. 93, no. 7, 2004.
10. S. W. Chen, R. S. Ingram, M. J. Hostetler et al., "Gold nano-electrodes of varied size: transition to molecule-like charging," Science, vol. 280, no. 5372, pp. 2098-2101, 1998.
11. J. F. Hicks, A. C. Templeton, S. Chen et al., "The monolayer thickness dependence of quantized double-layer capacitances of monolayer-protected gold clusters," Analytical Chemistry, vol. 71, no. 17, pp. 3703-3711, 1999.
12. J. F. Hicks, D. T. Miles, and R. W. Murray, "Quantized double-layer charging of highly monodisperse metal nanoparticles," Journal of the American Chemical Society, vol. 124, no. 44, pp. 13322-13328, 2002.
13. B. M. Quinn, P. Liljeroth, V. Ruiz, T. Laaksonen, and K. Kontturi, "Electrochemical resolution of 15 oxidation states for monolayer protected gold nanoparticles," Journal of the American Chemical Society, vol. 125, no. 22, pp. 6644-6645, 2003.
14. K. S. Park, M. I. Kim, M.-A. Woo, and H. G. Park, "A label-free method for detecting biological thiols based on blocking of Hg-quenching of fuorescent gold nanoclusters," Biosensors & Bio electronics, vol. 45, no. 1, pp. 65-69, 2013.
15. N. L. Rosi and C. A. Mirkin, "Nanostructures in biodiagnostics," Chemical Reviews, vol. 105, no. 4, pp. 1547-1562, 2005.
16. C.-A. J. Lin, T.-Y Yang, C.-H. Lee et al., "Synthesis, characterization, and bioconjugation of fuorescent gold nanoclusters toward biological labeling applications," ACS Nano, vol. 3, no. 2, pp. 395-401, 2009.
17. F. Wang, W. B. Tan, Y Zhang, X. P. Fan, and M. Q. Wang, "Luminescent nanomaterials for biological labelling," Nanotechnology, vol. 17, no. 1, pp. R1-R13, 2006.
18. G. Wang, T. Huang, R. W. Murray, L. Menard, and R. G. Nuzzo, "Near-IR luminescence of monolayer-protected metal clusters," Journal of the American Chemical Society, vol. 127, no. 3, pp. 812-813, 2005.
19. X. Li, F. Zhang, and D. Zhao, "Highly efcient lanthanide upconverting nanomaterials: progresses and challenges," Nano Today, vol. 8, no. 6, pp. 643-676, 2013.
20. I. Díez and R. H. A. Ras, "Fluorescent silver nanoclusters," Nanoscale, vol. 3, no. 5, pp. 1963-1970, 2011.
21. H. Xu and K. S. Suslick, "Water-soluble fuorescent silver nanoclusters," Advanced Materials, vol. 22, no. 10, pp. 1078-1082, 2010.
22. M. A. H. Muhammed and T. Pradeep, "Luminescent quantum clusters of gold as bio-labels," in Advanced Fluorescence Reporters in Chemistry and Biology II, vol. 9 of Springer Series on Fluorescence, pp. 333-353, Springer, Berlin, Germany, 2010.
23. I. Díez and R. H. A. Ras, "Few-atom silver clusters as fuorescent reporters," in Advanced Fluorescence Reporters in Chemistry and Biology II, vol. 9 of Springer Series on Fluorescence, pp. 307-332, Springer, Berlin, Germany, 2010.
24. C.-A. J. Lin, C.-H. Lee, J.-T. Hsieh et al., "Synthesis of fuorescent metallic nanoclusters toward biomedical application: recent progress and present challenges," Journal of Medical and Biological Engineering, vol. 29, no. 6, pp. 276-283, 2009.
25. J. Zheng, Fluorescent Noble Metal Nanoclusters, Georgia Institute of Technology, 2005.
26. J. Zheng, P. R. Nicovich, and R. M. Dickson, "Highly fuorescent noble-metal quantum dots," Annual Review of Physical Chemistry, vol. 58, pp. 409-431, 2007
27. G. K. Wertheim, S. B. DiCenzo, and D. N. E. Buchanan, "Noble-and transition-metal clusters: the d bands of silver and palladium," Physical Review B, vol. 33, no. 8, pp. 5384-5390, 1986.
28. 25-n nanoclusters: the 13 th silver atom matters," Angewandte Chemie-International Edition, vol. 53, no. 9, pp. 2376-2380, 2014.
29. G. A. Ozin and S. A. Mitchell, "Ligand-free metal clusters," Angewandte Chemie International Edition, vol. 22, no. 9, pp. 674-694, 1983.
30. Z. Q. Zhang, R. C. Patel, R. Kothari, C. P. Johnson, S. E. Friberg, and P. A. Aikens, "Stable silver clusters and nanoparticles prepared in polyacrylate and inverse micellar solutions," Journal of Physical Chemistry B, vol. 104, no. 6, pp. 1176-1182, 2000.
31. T. Huang and R. W. Murray, "Visible luminescence of water-soluble monolayer-protected gold clusters," Journal of Physical Chemistry B, vol. 105, no. 50, pp. 12498-12502, 2001.
32. S. Link, A. Beeby, S. FitzGerald, M. A. El-Sayed, T. G. Schaaf, and R. L. Whetten, "Visible to infrared luminescence from a 28-atom gold cluster," The Journal of Physical Chemistry B, vol. 106, no. 13, pp. 3410-3415, 2002.
33. C.-C. Huang, Z. Yang, K.-H. Lee, and H.-T Chang, "Synthesis of highly fuorescent gold nanoparticles for sensing mercury(II)," Angewandte Chemie International Edition, vol. 46, no. 36, pp. 6824-6828, 2007
34. 8 nanodots," Journal of the American Chemical Society, vol. 125, no. 26, pp. 7780-7781, 2003.
35. N. Schaefer, B. Tan, C. Dickinson et al., "Fluorescent or not? Size-dependent fuorescence switching for polymer-stabilized gold clusters in the 1.1-1.7 nm size range," Chemical Communications, no. 34, pp. 3986-3988, 2008.
36. B. Santiago Gonzalez, M. J. Rodríguez, C. Blanco, J. Rivas, M. A. López-Quintela, and J. M. G Martinho, "One step synthesis of the smallest photoluminescent and paramagnetic PVP-protected gold atomic clusters," Nano Letters, vol. 10, no. 10, pp. 4217-4221, 2010.
37. J. Xie, Y Zheng, and J. Y Ying, "Protein-directed synthesis of highly fuorescent gold nanoclusters," Journal of the American Chemical Society, vol. 131, no. 3, pp. 888-889, 2009.
38. Y Kong, J. Chen, F. Gao et al., "Near-infrared fuorescent ribonuclease-A-encapsulated gold nanoclusters: preparation, characterization, cancer targeting and imaging," Nanoscale, vol. 5, no. 3, pp. 1009-1017, 2013.
39. W.-Y. Chen, G.-Y. Lan, and H.-T. Chang, "Use of fuorescent DNA-templated gold/silver nanoclusters for the detection of sulfde ions," Analytical Chemistry, vol. 83, no. 24, pp. 9450-9455, 2011.
40. J. A. Annie Ho, H. C. Chang, and W. T. Su, "DOPA-mediated reduction allows the facile synthesis of fuorescent gold nanoclusters for use as sensing probes for ferric ions," Analytical Chemistry, vol. 84, no. 7, pp. 3246-3253, 2012.
41. L. Shang, R. M. Dörlich, S. Brandholt et al., "Facile preparation of water-soluble fuorescent gold nanoclusters for cellular imaging applications," Nanoscale, vol. 3, no. 5, pp. 2009-2014, 2011.
42. V. Venkatesh, A. Shukla, S. Sivakumar, and S. Verma, "Purine-stabilized green fuorescent gold nanoclusters for cell nuclei imaging applications," ACS Applied Materials and Interfaces, vol. 6, no. 3, pp. 2185-2191, 2014.
43. X. Liu, C. Li, J. Xu et al., "Surfactant-free synthesis and functionalization of highly fuorescent gold quantum dots," Journal of Physical Chemistry C, vol. 112, no. 29, pp. 10778-10783, 2008.
44. C. Zhou, C. Sun, M. Yu et al., "Luminescent gold nanoparticles with mixed valence states generated from dissociation of polymeric Au(I) thiolates," Journal of Physical Chemistry C, vol. 114, no. 17, pp. 7727-7732, 2010.
45. Z. Luo, X Yuan, Y Yu et al., "From aggregation-induced emission of Au(I)-thiolate complexes to ultrabright Au(0)@Au(I)-thiolate core-shell nanoclusters," Journal of the American Chemical Society, vol. 134, no. 40, pp. 16662-16670, 2012.
46. + with good sensitivity and selectivity," Analyst, vol. 137, no. 2, pp. 301-304, 2012.
47. F. Aldeek, M. A. H. Muhammed, G. Palui, N. Zhan, and H. Mattoussi, "Growth of highly fuorescent polyethylene glycoland zwitterion-functionalized gold nanoclusters," ACS Nano, vol. 7, no. 3, pp. 2509-2521, 2013.
48. 8 clusters by interfacial synthesis," Angewandte Chemie-International Edition, vol. 49, no. 23, pp. 3925-3929, 2010.
49. J.-I. Nishigaki, S. Yamazoe, S. Kohara et al., "A twisted bi-icosahedral Au25 cluster enclosed by bulky arenethiolates," Chemical Communications, vol. 50, no. 7, pp. 839-841, 2014.
50. 50 nanomolecules through core size conversion of larger metal clusters," Physical Chemistry Chemical Physics, vol. 16, no. 22, pp. 10473-10479, 2014.
51. X. Yuan, Z. Luo, Q. Zhang et al., "Synthesis of highly fuorescent metal (Ag, Au, Pt, and Cu) nanoclusters by electrostatically induced reversible phase transfer," ACS Nano, vol. 5, no. 11, pp. 8800-8808, 2011.
52. X. Huang, Y Luo, Z. Li et al., "Biolabeling hematopoietic system cells using near-infrared fuorescent gold nanoclusters," The Journal of Physical Chemistry C, vol. 115, no. 34, pp. 16753-16763, 2011.
53. D. Joseph and K. E. Geckeler, "Synthesis of highly fuorescent gold nanoclusters using egg white proteins," Colloids and Surfaces B: Biointerfaces, vol. 115, pp. 46-50, 2014.
54. + based on the fuorescence quenching of lysozyme Type VI-stabilized gold nanoclusters," Analytical Chemistry, vol. 82, no. 22, pp. 9194-9200, 2010.
55. J. Zheng and R. M. Dickson, "Individual water-soluble dendrimer-encapsulated silver nanodot fuorescence," Journal of the American Chemical Society, vol. 124, no. 47, pp. 13982-13983, 2002.
56. C. I. Richards, S. Choi, J.-C. Hsiang et al., "Oligonucleotide-stabilized Ag nanocluster fuorophores," Journal of the American Chemical Society, vol. 130, no. 15, pp. 5038-5039, 2008.
57. B. Han and E. Wang, "DNA-templated fuorescent silver nanoclusters," Analytical and Bioanalytical Chemistry, vol. 402, no. 1, pp. 129-138, 2012.
58. D. A. Tomalia and J. M. J. Fréchet, "Discovery of dendrimers and dendritic polymers: a brief historical perspective," Journal of Polymer Science, Part A: Polymer Chemistry, vol. 40, no. 16, pp. 2719-2728, 2002.
59. D A. Tomalia, "Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic organic chemistry," Aldrichimica Acta, vol. 37, no. 2, pp. 39-57, 2004.
60. B. Yuping, Z. Chang, D. M. Vu, J. P. Temirov, R. B. Dyer, and J. S. Martinez, "Nanoparticle-free synthesis of fuorescent gold nanoclusters at physiological temperature," The Journal of Physical Chemistry C, vol. 111, no. 33, pp. 12194-12198, 2007
61. Y.-C. Jao, M.-K. Chen, and S.-Y Lin, "Enhanced quantum yield of dendrimer-entrapped gold nanodots by a specifc ion-pair association and microwave irradiation for bioimaging," Chemical Communications, vol. 46, no. 15, pp. 2626-2628, 2010.
62. L. Maya, G. Muralidharan, T. G. Tundat, and E. A. Kenik, "Polymer-mediated assembly of gold nanoclusters," Langmuir, vol. 16, no. 24, pp. 9151-9154, 2000.
63. X. Huang, B. Li, L. Li et al., "Facile preparation of highly blue fuorescent metal nanoclusters in organic media," Journal of Physical Chemistry C, vol. 116, no. 1, pp. 448-455, 2012.
64. H. Duan and S. Nie, "Etching colloidal gold nanocrystals with hyperbranched and multivalent polymers: a new route to fuorescent and water-soluble atomic clusters," Journal of the American Chemical Society, vol. 129, no. 9, pp. 2412-2413, 2007
65. I. Hussain, S. Graham, Z. X. Wang et al., "Size-controlled synthesis of near-monodisperse gold nanoparticles in the 1-4 nm range using polymeric stabilizers," Journal of the American Chemical Society, vol. 127, no. 47, pp. 16398-16399, 2005.
66. Z. Wang, B. Tan, I. Hussain et al., "Design of polymeric stabilizers for size-controlled synthesis of monodisperse gold nanoparticles in water," Langmuir, vol. 23, no. 2, pp. 885-895, 2007
67. Y Chen, X. Zheng, X Wang, C. Wang, Y Ding, and X Jiang, "Near-infrared emitting gold cluster-poly(acrylic acid) hybrid nanogels," ACS Macro Letters, vol. 3, no. 1, pp. 74-76, 2014.
68. C.-L. Liu, H.-T. Wu, Y.-H. Hsiao et al., "Insulin-directed synthesis of fuorescent gold nanoclusters: preservation of insulin bioactivity and versatility in cell imaging," Angewandte Chemie International Edition, vol. 50, no. 31, pp. 7056-7060, 2011.
69. A. R. Garcia, I. Rahn, S. Johnson et al., "Human insulin fbril-assisted synthesis of fuorescent gold nanoclusters in alkaline media under physiological temperature," Colloids and Surfaces B: Biointerfaces, vol. 105, pp. 167-172, 2013.
70. C. Guo and J. Irudayaraj, "Fluorescent Ag clusters via a protein-directed approach as a Hg(II) ion sensor," Analytical Chemistry, vol. 83, no. 8, pp. 2883-2889, 2011.
71. 2+ sensor," Analyst, vol. 135, no. 6, pp. 1406-1410, 2010.
72. J. Qiao, X. Mu, L. Qi, J. Deng, and L. Mao, "Folic acid-functionalized fuorescent gold nanoclusters with polymers as linkers for cancer cell imaging," Chemical Communications, vol. 49, no. 73, pp. 8030-8032, 2013.
73. E. S. Kryachko and F. Remade, "Complexes of DNA bases and Watson-Crick base pairs with small neutral gold clusters," Journal of Physical Chemistry B, vol. 109, no. 48, pp. 22746-22757, 2005.
74. M. K. Shukla, M. Dubey, E. Zakar, and J. Leszczynski, "DFT investigation of the interaction of gold nanoclusters with nucleic acid base guanine and the watson-crick guanine-cytosine base pair," Journal of Physical Chemistry C, vol. 113, no. 10, pp. 3960-3966, 2009.
75. R. Zhou, M. Shi, X. Chen, M. Wang, and H. Chen, "Atomically monodispersed and fuorescent sub-nanometer gold clusters created by biomolecule-assisted etching of nanometer-sized gold particles and rods," Chemistry-A European Journal, vol. 15, no. 19, pp. 4944-4951, 2009.
76. T. A. C. Kennedy, J. L. MacLean, and J. Liu, "Blue emitting gold nanoclusters templated by poly-cytosine DNA at low pH and poly-adenine DNA at neutral pH," Chemical Communications, vol. 48, no. 54, pp. 6845-6847, 2012.
77. G. Liu, Y. Shao, K. Ma, Q. Cui, F. Wu, and S. Xu, "Synthesis of DNA-templated fuorescent gold nanoclusters," Gold Bulletin, vol. 45, no. 2, pp. 69-74, 2012.
78. H. Kawasaki, H. Yamamoto, H. Fujimori, R. Arakawa, Y Iwasaki, and M. Inada, "Stability of the DMF-protected Au nanoclusters: photochemical, dispersion, and thermal properties," Langmuir, vol. 26, no. 8, pp. 5926-5933, 2010.
79. S. Palmal, S. Basiruddin, A. R. Maity, S. C. Ray, and N. R. Jana, "Tiol-directed synthesis of highly fuorescent gold clusters and their conversion into stable imaging nanoprobes," Chemistry, vol. 19, no. 3, pp. 943-949, 2013.
80. H. Chen, B. Li, C. Wang et al., "Characterization of a fuorescence probe based on gold nanoclusters for cell and animal imaging," Nanotechnology, vol. 24, no. 5, Article ID 055704, 2013.
81. Y Zhang, Q. Hu, M. C. Paauet al., "Probing histidine-stabilized gold nanoclusters product by high-performance liquid chromatography and mass spectrometry," Journal of Physical Chemistry C, vol. 117, no. 36, pp. 18697-18708, 2013.
82. X. Mu, L. Qi, P. Dong et al., "Facile one-pot synthesis of l-proline-stabilized fuorescent gold nanoclusters and its application as sensing probes for serum iron," Biosensors and Bioelectronics, vol. 49, pp. 249-255, 2013.
83. 4 and histidine in aqueous solution: a simple approach to the Au10 cluster," Nanoscale, vol. 3, no. 6, pp. 2596-2601, 2011.
84. R. de la Rica, L. W. Chow, C.-M. Horejs et al., "A designer peptide as a template for growing Au nanoclusters," Chemical Communications, vol. 50, no. 73, pp. 10648-10650, 2014.
85. Y Wang, Y Cui, Y Zhao et al., "Bifunctional peptides that precisely biomineralize Au clusters and specifcally stain cell nuclei," Chemical Communications, vol. 48, no. 6, pp. 871-873, 2012.
86. Y Bao, H.-C. Yeh, C. Zhong et al., "Formation and stabilization of fuorescent gold nanoclusters using small molecules," Journal of Physical Chemistry C, vol. 114, no. 38, pp. 15879-15882, 2010.
87. C. A. Simpson, C. L. Farrow, P. Tian et al., "Tiopronin gold nanoparticle precursor forms aurophilic ring tetramer," Inorganic Chemistry, vol. 49, no. 23, pp. 10858-10866, 2010.
88. 25 nanoclusters via protection-deprotection method," Journal of Physical Chemistry Letters, vol. 3, no. 17, pp. 2310-2314, 2012.
89. Y Bao, C. Zhong, D. M. Vu, J. P. Temirov, R. B. Dyer, and J. S. Martinez, "Nanoparticle-free synthesis of fuorescent gold nanoclusters at physiological temperature," The Journal of Physical Chemistry C, vol. 111, no. 33, pp. 12194-12198, 2007
90. 11 clusters," Journal of the American Chemical Society, vol. 127, no. 39, pp. 13464-13465, 2005.
91. M. Yu, C. Zhou, J. Liu, J. D. Hankins, and J. Zheng, "Luminescent gold nanoparticles with pH-dependent membrane adsorption," Journal of the American Chemical Society, vol. 133, no. 29, pp. 11014-11017, 2011.
92. M. McPartlin, R. Mason, and L. Malatesta, "Novel cluster complexes of gold(0)-gold(I)," Journal of the Chemical Society D: Chemical Communications, no. 7, p. 334, 1969.
93. n2 with an interstitial gold atom in a hexagonal antiprismatic cage," Journal of the American Chemical Society, vol. 114, no. 7, pp. 2743-2745, 1992.
94. 3; the realization of a theoretical prediction," Journal of the Chemical Society Chemical Communications, no. 5, pp. 201-202, 1981.
95. 6-agold-clusterofanexceptional size," Chemische Berichte/Recueil, vol. 114, no. 11, pp. 3634-3642, 1981.
96. W. W. Weare, S. M. Reed, M. G. Warner, and J. E. Hutchison, "Improved synthesis of small (d(CORE)approximateto 1.5 nm) phosphine-stabilized gold nanoparticies," Journal of the American Chemical Society, vol. 122, no. 51, pp. 12890-12891, 2000.
97. X. K. Wan, S. F. Yuan, Z. W. Lin, and Q. M. Wang, "A chiral gold nanocluster Au20 protected by tetradentate phosphine ligands," Angewandte Chemie-International Edition, vol. 53, no. 11, pp. 2923-2926, 2014.
98. G. H. Woehrle, L. O. Brown, and J. E. Hutchison, "Tiol-functionalized, 1.5-nm gold nanoparticles through ligand exchange reactions: scope and mechanism of ligand exchange," Journal of the American Chemical Society, vol. 127, no. 7, pp. 2172-2183, 2005.
99. M. Brust, M. Walker, D. Bethell, D. J. Schifrin, and R. Whyman, "Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid-liquid system," Journal of the Chemical Society Chemical Communications, no. 7, pp. 801-802, 1994.
100. R. Jin, H. Qian, Z. Wu et al., "Size focusing: a methodology for synthesizing atomically precise gold nanoclusters," Journal of Physical Chemistry Letters, vol. 1, no. 19, pp. 2903-2910, 2010.
101. 25 nanoclusters," Journal of Materials Chemistry, vol. 19, no. 5, pp. 622-626, 2009.
102. T. G. Schaaf, G. Knight, M. N. Shafgullin, R. F. Borkman, and R. L. Whetten, "Isolation and selected properties of a 10.4 kDa gold: glutathione cluster compound," Journal of Physical Chemistry B, vol. 102, no. 52, pp. 10643-10646, 1998.
103. Y. Negishi, Y. Takasugi, S. Sato, H. Yao, K. Kimura, and T. Tsukuda, "Magic-numbered Aun clusters protected by glutathione monolayers (n = 18, 21, 25, 28, 32, 39): Isolation and spectroscopic characterization," Journal of the American Chemical Society, vol. 126, no. 21, pp. 6518-6519, 2004.
104. Y Negishi, K. Nobusada, and T. Tsukuda, "Glutathione-protected gold clusters revisited: bridging the gap between gold(I)-thiolate complexes and thiolate-protected gold nanocrystals," Journal of the American Chemical Society, vol. 127, no. 14, pp. 5261-5270, 2005.
105. H. Zhang, Q. Liu, T. Wang et al., "Facile preparation of glutathione-stabilized gold nanoclusters for selective determination of chromium (III) and chromium (VI) in environmental water samples," Analytica Chimica Acta, vol. 770, pp. 140-146, 2013.
106. A. C. Templeton, S. Chen, S. M. Gross, and R. W. Murray, "Water-soluble, isolable gold clusters protected by tiopronin and coenzyme a monolayers," Langmuir, vol. 15, no. 1, pp. 66-76, 1999.
107. D. Lee, R. L. Donkers, G. Wang, A. S. Harper, and R. W. Murray, "Electrochemistry and optical absorbance and luminescence of molecule-like Au38 nanoparticles," Journal of the American Chemical Society, vol. 126, no. 19, pp. 6193-6199, 2004.
108. M. C. Paau, C. K. Lo, X. Yang, and M. M. F. Choi, "Synthesis of 1.4 nm oc-cyclodextrin-protected gold nanoparticles for luminescence sensing of mercury(II) with picomolar detection limit," Journal of Physical Chemistry C, vol. 114, no. 38, pp. 15995-16003, 2010.
109. E. S. Shibu and T. Pradeep, "Quantum clusters in cavities: trapped Au15 in cyclodextrins," Chemistry of Materials, vol. 23, no. 4, pp. 989-999, 2011.
110. H. Zhang, X. Huang, L. Li et al., "Photoreductive synthesis of water-soluble fuorescent metal nanoclusters," Chemical Communications, vol. 48, no. 4, pp. 567-569, 2012.
111. Y Shiraishi, D. Arakawa, and N. Toshima, "pH-dependent color change of colloidal dispersions of gold nanoclusters: efect of stabilizer," European Physical Journal E, vol. 8, no. 4, pp. 377-383, 2002.
112. L. Shang, N. Azadfar, F. Stockmar et al., "One-pot synthesis of near-infrared fuorescent gold clusters for cellular fuorescence lifetime imaging," Small, vol. 7, no. 18, pp. 2614-2620, 2011.
113. N. K. Chaki, P. Singh, C. V. Dharmadhikari, and K. P. Vijayamo-hanan, "Single-electron charging features of larger, dodecane-thiol-protected gold nanoclusters: electrochemical and scanning tunneling microscopy studies," Langmuir, vol. 20, no. 23, pp. 10208-10217, 2004.
114. H. Yao, K. Miki, N. Nishida, A. Sasaki, and K. Kimura, "Large optical activity of gold nanocluster enantiomers induced by a pair of optically active penicillamines," Journal of the American Chemical Society, vol. 127, no. 44, pp. 15536-15543, 2005.
115. X. Yang, L. Gan, L. Han, D. Li, J. Wang, and E. Wang, "Facile preparation of chiral penicillamine protected gold nanoclusters and their applications in cell imaging," Chemical Communications, vol. 49, no. 23, pp. 2302-2304, 2013.
116. M. A. H. Muhammed, S. Ramesh, S. S. Sinha, S. K. Pal, and T. Pradeep, "Two distinct fuorescent quantum clusters of gold starting from metallic nanoparticles by pH-dependent ligand etching," Nano Research, vol. 1, no. 4, pp. 333-340, 2008.
117. 24 nanoclusters," ACS Nano, vol. 3, no. 11, pp. 3795-3803, 2009.
118. H. Qian, M. Zhu, Z. Wu, and R. Jin, "Quantum sized gold nanoclusters with atomic precision," Accounts of Chemical Research, vol. 45, no. 9, pp. 1470-1479, 2012.
119. T. G. Schaaf and R. L. Whetten, "Controlled Etching of Au: SR cluster Compounds," Journal of Physical Chemistry B, vol. 103, no. 44, pp. 9394-9396, 1999.
120. R. A. Sperling and W. J. Parak, "Surface modifcation, function-alization and bioconjugation of colloidal Inorganic nanoparticles," Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 368, no. 1915, pp. 1333-1383, 2010.
121. S. Jiang, K. Y Win, S. Liu, C. P. Teng, Y Zheng, and M.-Y Han, "Surface-functionalized nanoparticles for biosensing and imaging-guided therapeutics," Nanoscale, vol. 5, no. 8, pp. 3127-3148, 2013.
122. N. Erathodiyil and J. Y Ying, "Functionalization of inorganic nanoparticles for bioimaging applications," Accounts of Chemical Research, vol. 44, no. 10, pp. 925-935, 2011.
123. X. Le Gúevel, B. Hötzer, G. Jung, and M. Schneider, "NIR-emitting fuorescent gold nanoclusters doped in silica nanoparticles," Journal of Materials Chemistry, vol. 21, no. 9, pp. 2974-2981, 2011.
124. C. A. J. Lin, R. A. Sperling, J. K. Li et al., "Design of an amphiphilic polymer for nanoparticle coating and functionalization," Small, vol. 4, no. 3, pp. 334-341, 2008.
125. S.-K. Sun, L.-X. Dong, Y. Cao, H.-R. Sun, and X.-P. Yan, "Fabrication of multifunctional Gd2O3/Au hybrid nanoprobe via a one-step approach for near-infrared fuorescence and magnetic resonance multimodal imaging in vivo," Analytical Chemistry, vol. 85, no. 17, pp. 8436-8441, 2013.
126. J. M. Abad, S. F. L. Mertens, M. Pita, V. M. Fernandez, and D. J. Schifrin, "Functionalization of thioctic acid-capped gold nanoparticles for specifc immobilization of histidine-tagged proteins," Journal of the American Chemical Society, vol. 127, no. 15, pp. 5689-5694, 2005.
127. F. Wen, Y Dong, L. Feng, S. Wang, S. Zhang, and X Zhang, "Horseradish peroxidase functionalized fuorescent gold nanoclusters for hydrogen peroxide sensing," Analytical Chemistry, vol. 83, no. 4, pp. 1193-1196, 2011.
128. +," Journal of Colloid and Interface Science, vol. 396, pp. 63-68, 2013.
129. C. Banerjee, J. Kuchlyan, D. Banik et al., "Interaction of gold nanoclusters with IR light emitting cyanine dyes: a systematic fuorescence quenching study," Physical Chemistry Chemical Physics, vol. 16, no. 32, pp. 17272-17283, 2014.
130. + in aqueous solution based on structure-switching DNA," Chemical Communications, no. 45, pp. 6005-6007, 2008.
131. Z. Gu, M. Zhao, Y Sheng, L. A. Bentolila, and Y Tang, "Detection of mercury ion by infrared fuorescent protein and its hydrogel-based paper assay," Analytical Chemistry, vol. 83, no. 6, pp. 2324-2329, 2011.
132. M. Matsushita, M. M. Meijler, P. Wirsching, R. A. Lerner, and K. D. Janda, "A blue fuorescent antibody-cofactor sensor for mercury," Organic Letters, vol. 7, no. 22, pp. 4943-4946, 2005.
133. B. Ruttkay-Nedecky, J. Kudr, L. Nejdl, D. Maskova, R. Kizek, and V. Adam, "G-quadruplexes as sensingprobes," Molecules, vol. 18, no. 12, pp. 14760-14779, 2013.
134. J. Liu and Y. Lu, "Rational Design of 'turn-On' allosteric DNAzyme catalytic beacons for aqueous mercury ions with ultrahigh sensitivity and selectivity," Angewandte Chemie, vol. 46, no. 40, pp. 7587-7590, 2007.
135. 2+ collectively and individually using phosphorothioate DNAzymes," Analytical Chemistry, vol. 86, no. 12, pp. 5999-6005, 2014.
136. B.-C. Ye and B.-C. Yin, "Highly sensitive detection of mer-cury(II) ions by fuorescence polarization enhanced by gold nanoparticles," Angewandte Chemie International Edition, vol. 47, no. 44, pp. 8386-8389, 2008.
137. C.-W. Tseng, H.-Y. Chang, J.-Y. Chang, and C.-C. Huang, "Detection of mercury ions based on mercury-induced switching of enzyme-like activity of platinum/gold nanoparticles," Nanoscale, vol. 4, no. 21, pp. 6823-6830, 2012.
138. 2+ by cyanobacteria in aqueous media," Chemical Communications, no. 18, pp. 2496-2498, 2009.
139. Nuriman, B. Kuswandi, and W. Verboom, "Selective chemosen-sor for Hg(II) ions based on tris[2-(4-phenyldiazenyl)phe-nylaminoethoxy]cyclotriveratrylene in aqueous samples," Ana-lytica Chimica Acta, vol. 655, no. 1-2, pp. 75-79, 2009.
140. S. Voutsadaki, G. K. Tsikalas, E. Klontzas, G. E. Froudakis, and H. E. Katerinopoulos, "A 'turn-on' coumarin-based fuorescent sensor with high selectivity for mercury ions in aqueous media," Chemical Communications, vol. 46, no. 19, pp. 3292-3294, 2010.
141. + interactions," Chemical Communications, vol. 46, no. 6, pp. 961-963, 2010.
142. T. Mayr, I. Klimant, O. S. Wolfeis, and T. Werner, "Dual lifetime referenced optical sensor membrane for the determination of copper(II) ions," Analytica Chimica Acta, vol. 462, no. 1, pp. 1-10, 2002.
143. M. E. Letelier, A. M. Lepe, M. Faúndez et al., "Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity," Chemico-Biological Interactions, vol. 151, no. 2, pp. 71-82, 2005.
144. L. M. Gaetke and C. K. Chow, "Copper toxicity, oxidative stress, and antioxidant nutrients," Toxicology, vol. 189, no. 1-2, pp. 147-163, 2003.
145. 2+ ions," Chemical Communications, no. 13, pp. 1736-1738, 2009.
146. X. Tu, W. Chen, and X. Guo, "Facile one-pot synthesis of near-infrared luminescent gold nanoparticles for sensing copper (II)," Nanotechnology, vol. 22, no. 9, Article ID 095701, 2011.
147. 2+ based on lysine-functionalized gold nanoclus-ters," Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 450, pp. 115-120, 2014.
148. D. Cao, J. Fan, J. Qiu, Y. Tu, and J. Yan, "Masking method for improving selectivity of gold nanoclusters in fuorescence determination of mercury and copper ions," Biosensors & Bioelectronics, vol. 42, no. 1, pp. 47-50, 2013.
149. J.-A. Annie Ho, H.-C. Chang, and W.-T. Su, "DOPA-mediated reduction allows the facile synthesis of fuorescent gold nan-oclusters for use as sensing probes for ferric ions," Analytical Chemistry, vol. 84, no. 7, pp. 3246-3253, 2012.
150. Y.-C. Shiang, C.-C. Huang, and H.-T. Chang, "Gold nanodot-based luminescent sensor for the detection of hydrogen peroxide and glucose," Chemical Communications, no. 23, pp. 3437-3439, 2009.
151. L. Hu, S. Han, S. Parveen, Y. Yuan, L. Zhang, and G. Xu, "Highly sensitive fuorescent detection of trypsin based on BSA-stabilized gold nanoclusters," Biosensors & Bioelectronics, vol. 32, no. 1, pp. 297-299, 2012.
152. Q. Wen, Y. Gu, L. J. Tang, R. Q. Yu, and J.-H. Jiang, "Peptide-templated gold nanocluster beacon as a sensitive, label-free sensor for protein post-translational modifcation enzymes," Analytical Chemistry, vol. 85, no. 24, pp. 11681-11685, 2013.
153. X. Yang, Y. Luo, Y. Zhuo, Y. Feng, and S. Zhu, "Novel synthesis of gold nanoclusters templated with l-tyrosine for selective analyzing tyrosinase," Analytica Chimica Acta, vol. 840, pp. 87-92, 2014.
154. 2+ modulated BSA-Au nanoclus-ters: a versatile fuorescence turn-on sensor for dopamine," Microchemical Journal, vol. 116, pp. 151-156, 2014.
155. Y. Tao, Y. Lin, J. Ren, and X. Qu, "A dual fuorometric and colorimetric sensor for dopamine based on BSA-stabilized Au nanoclusters," Biosensors & Bioelectronics, vol. 42, no. 1, pp. 41-46, 2013.
156. L. Li, H. Liu, Y. Shen, J. Zhang, and J. J. Zhu, "Electrogenerated chemiluminescence of Au nanoclusters for the detection of dopamine," Analytical Chemistry, vol. 83, no. 3, pp. 661-665, 2011.
157. H. Liu, G. Yang, E. S. Abdel-Halim, and J.-J. Zhu, "Highly selective and ultrasensitive detection of nitrite based on fuorescent gold nanoclusters," Talanta, vol. 104, pp. 135-139, 2013.
158. X. Chen and G. A. Baker, "Cholesterol determination using protein-templated fuorescent gold nanocluster probes," Analyst, vol. 138, no. 24, pp. 7299-7302, 2013.
159. B. Hemmateenejad, F. Shakerizadeh-Shirazi, and F. Samari, "BSA-modifed gold nanoclusters for sensing of folic acid," Sensors and Actuators, B: Chemical, vol. 199, pp. 42-46, 2014.
160. Z. Chen, S. Qian, J. Chen, J. Cai, S. Wu, and Z. Cai, "Protein-templated gold nanoclusters based sensor for of-on detection of ciprofoxacin with a high selectivity," Talanta, vol. 94, pp. 240-245, 2012.
161. G.-H. Yang, J.-J. Shi, S. Wang et al., "Fabrication of a boron nitride-gold nanocluster composite and its versatile application for immunoassays," Chemical Communications, vol. 49, no. 91, pp. 10757-10759, 2013.
162. R. C. Triulzi, M. Micic, S. Giordani, M. Serry, W. A. Chiou, and R. M. Leblanc, "Immunoasssay based on the antibody-conjugated PAMAM-dendrimer-gold quantum dot complex," Chemical Communications, no. 48, pp. 5068-5070, 2006.
163. H. Lin, L. Li, C. Lei et al., "Immune-independent and label-free fuorescent assay for Cystatin C detection based on protein-stabilized Au nanoclusters," Biosensors and Bioelectronics, vol. 41, no. 1, pp. 256-261, 2013.
164. K. Selvaprakash and Y.-C. Chen, "Using protein-encapsulated gold nanoclusters as photoluminescent sensing probes for biomolecules," Biosensors & Bioelectronics, vol. 61, pp. 88-94, 2014.
165. C.-C. Huang, C.-K. Chiang, Z.-H. Lin, K.-H. Lee, and H.-T. Chang, "Bioconjugated gold nanodots and nanoparticles for protein assays based on photoluminescence quenching," Analytical Chemistry, vol. 80, no. 5, pp. 1497-1504, 2008.
166. C. C. Huang, C. T. Chen, Y. C. Shiang, Z. H. Lin, and H. T. Chang, "Synthesis of fuorescent carbohydrate-protected Au nanodots for detection of Concanavalin A and Escherichia coli," Analytical Chemistry, vol. 81, no. 3, pp. 875-882, 2009.
167. J. Zhang, M. Sajid, N. Na, L. Huang, D. He, and J. Ouyang, "The application of Au nanoclusters in the fuorescence imaging of human serum proteins afer native PAGE: enhancing detection by low-temperature plasma treatment," Biosensors and Bioelec-tronics, vol. 35, no. 1, pp. 313-318, 2012.
168. A. M. P. Hussain, S. N. Sarangi, J. A. Kesarwani, and S. N. Sahu, "Au-nanocluster emission based glucose sensing," Biosensors & Bioelectronics, vol. 29, no. 1, pp. 60-65, 2011.
169. L. Jin, L. Shang, S. Guo et al., "Biomolecule-stabilized Au nanoclusters as a fuorescence probe for sensitive detection of glucose," Biosensors & Bioelectronics, vol. 26, no. 5, pp. 1965-1969, 2011.
170. W. J. Stark, "Nanoparticles in biological systems," Angewandte Chemie International Edition, vol. 50, no. 6, pp. 1242-1258, 2011.
171. L. Shang and G. U. Nienhaus, "Small fuorescent nanoparticles at the nano-bio interface," Materials Today, vol. 16, no. 3, pp. 58-66, 2013.
172. H.-H. Wang, C. A. J. Lin, C. H. Lee et al., "Fluorescent gold nanoclusters as a biocompatible marker for in vitro and in vivo tracking of endothelial cells," ACS Nano, vol. 5, no. 6, pp. 4337-4344, 2011.
173. P.-H. Chan, S.-Y. Wong, S.-H. Lin, and Y.-C. Chen, "Lysozyme-encapsulated gold nanocluster-based afnity mass spectrom-etry for pathogenic bacteria," Rapid Communications in Mass Spectrometry, vol. 27, no. 19, pp. 2143-2148, 2013.
174. D. Hu, Z. Sheng, S. Fang et al., "Folate receptor-targeting gold nanoclusters as fuorescence enzyme mimetic nanoprobes for tumor molecular colocalization diagnosis," Teranostics, vol. 4, no. 2, pp. 142-153, 2014.
175. P. Botella, I. Ortega, M. Quesada et al., "Multifunctional hybrid materials for combined photo and chemotherapy of cancer," Dalton Transactions, vol. 41, no. 31, pp. 9286-9296, 2012.
176. P. Huang, J. Lin, S. Wang et al., "Photosensitizer-conjugated silica-coated gold nanoclusters for fuorescence imaging-guided photodynamic therapy," Biomaterials, vol. 34, no. 19, pp. 4643-4654, 2013.
177. + breast cancer," ACS Nano, vol. 5, no. 12, pp. 9718-9725, 2011.
178. X. Wang, X. Cai, J. Hu et al., "Glutathione-triggered 'Of-On' release of anticancer drugs from dendrimer-encapsulated gold nanoparticles," Journal of the American Chemical Society, vol. 135, no. 26, pp. 9805-9810, 2013.
179. C.-L. Liu, M.-L. Ho, Y.-C. Chen et al., "Tiol-functionalized gold nanodots: two-photon absorption property and imaging in vitro," Journal of Physical Chemistry C, vol. 113, no. 50, pp. 21082-21089, 2009.
180. Z. Zhou, C. Zhang, Q. Qian et al., "Folic acid-conjugated silica capped gold nanoclusters for targeted fuorescence/X-ray computed tomography imaging," Journal of Nanobiotechnology, vol. 11, article 17, 2013.
181. J. Wang, G. Zhang, Q. Li et al., "In vivo self-bio-imaging of tumors through in situ biosynthesized fuorescent gold nanoclusters," Scientifc reports, vol. 3, 2013.
182. G. Ramakrishna, O. Varnavski, J. Kim, D. Lee, and T. Good-son, "Quantum-sized gold clusters as efcient two-photon absorbers," Journal of the American Chemical Society, vol. 130, no. 15, pp. 5032-5033, 2008.
183. L. Polavarapu, M. Manna, and Q.-H. Xu, "Biocompatible glu-tathione capped gold clusters as one-and two-photon excitation fuorescence contrast agents for live cells imaging," Nanoscale, vol. 3, no. 2, pp. 429-434, 2011.
184. T. W. J. Gadella Jr., T. M. Jovin, and R. M. Clegg, "Fluorescence lifetime imaging microscopy (FLIM): spatial resolution of microstructures on the nanosecond time scale," Biophysical Chemistry, vol. 48, no. 2, pp. 221-239, 1993.
185. A. Zhang, Y. Tu, S. Qin et al., "Gold nanoclusters as contrast agents for fuorescent and X-ray dual-modality imaging," Journal of Colloid and Interface Science, vol. 372, no. 1, pp. 239-244, 2012.
186. A. Retnakumari, S. Setua, D. Menon et al., "Molecular-receptor-specifc, non-toxic, near-infrared-emitting Au cluster-protein nanoconjugates for targeted cancer imaging," Nanotechnology, vol. 21, no. 5, Article ID 055103, 2010.