메뉴 건너뛰기




Volumn 29, Issue 4, 2014, Pages 427-434

Metabolic and cardiovascular implications of a metabolically healthy obesity phenotype

Author keywords

Cardiovascular diseases; Diabetes; Metabolically healthy obesity

Indexed keywords


EID: 84940375955     PISSN: 2093596X     EISSN: 20935978     Source Type: Journal    
DOI: 10.3803/EnM.2014.29.4.427     Document Type: Review
Times cited : (57)

References (51)
  • 1
    • 0034109077 scopus 로고    scopus 로고
    • Obesity, insulin resistance and diabetes: a worldwide epidemic
    • Seidell JC. Obesity, insulin resistance and diabetes: a worldwide epidemic. Br J Nutr 2000;83 Suppl 1:S5-8.
    • (2000) Br J Nutr , vol.83 , pp. S5-S8
    • Seidell, J.C.1
  • 2
    • 79951690905 scopus 로고    scopus 로고
    • Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men
    • Arnlov J, Sundstrom J, Ingelsson E, Lind L. Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men. Diabetes Care 2011;34:61-5.
    • (2011) Diabetes Care , vol.34 , pp. 61-65
    • Arnlov, J.1    Sundstrom, J.2    Ingelsson, E.3    Lind, L.4
  • 4
    • 0018973369 scopus 로고
    • Effect of obesity on total mortality
    • Andres R. Effect of obesity on total mortality. Int J Obes 1980; 4:381-6.
    • (1980) Int J Obes , vol.4 , pp. 381-386
    • Andres, R.1
  • 5
    • 0035655253 scopus 로고    scopus 로고
    • Are there persons who are obese, but metabolically healthy?
    • Sims EA. Are there persons who are obese, but metabolically healthy? Metabolism 2001;50:1499-504.
    • (2001) Metabolism , vol.50 , pp. 1499-1504
    • Sims, E.A.1
  • 8
    • 84884500386 scopus 로고    scopus 로고
    • Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications
    • Stefan N, Haring HU, Hu FB, Schulze MB. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol 2013;1:152-62.
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 152-162
    • Stefan, N.1    Haring, H.U.2    Hu, F.B.3    Schulze, M.B.4
  • 10
    • 77649171169 scopus 로고    scopus 로고
    • The distinction of metabolically 'healthy' from 'unhealthy' obese individuals
    • Bluher M. The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol 2010;21: 38-43.
    • (2010) Curr Opin Lipidol , vol.21 , pp. 38-43
    • Bluher, M.1
  • 11
    • 82155162420 scopus 로고    scopus 로고
    • To be obese: does it matter if you are metabolically healthy?
    • Karelis AD. To be obese: does it matter if you are metabolically healthy? Nat Rev Endocrinol 2011;7:699-700.
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 699-700
    • Karelis, A.D.1
  • 14
    • 84885647821 scopus 로고    scopus 로고
    • Metabolically healthy obesity: definitions, determinants and clinical implications
    • Phillips CM. Metabolically healthy obesity: definitions, determinants and clinical implications. Rev Endocr Metab Disord 2013;14:219-27.
    • (2013) Rev Endocr Metab Disord , vol.14 , pp. 219-227
    • Phillips, C.M.1
  • 15
    • 84875327282 scopus 로고    scopus 로고
    • Comparison of metabolic characteristics of metabolically healthy but obese (MHO) middle-aged men according to different criteria
    • Yoo HK, Choi EY, Park EW, Cheong YS, Bae RA. Comparison of metabolic characteristics of metabolically healthy but obese (MHO) middle-aged men according to different criteria. Korean J Fam Med 2013;34:19-26.
    • (2013) Korean J Fam Med , vol.34 , pp. 19-26
    • Yoo, H.K.1    Choi, E.Y.2    Park, E.W.3    Cheong, Y.S.4    Bae, R.A.5
  • 18
    • 42649144463 scopus 로고    scopus 로고
    • Beneficial effects of subcutaneous fat transplantation on metabolism
    • Tran TT, Yamamoto Y, Gesta S, Kahn CR. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 2008;7:410-20.
    • (2008) Cell Metab , vol.7 , pp. 410-420
    • Tran, T.T.1    Yamamoto, Y.2    Gesta, S.3    Kahn, C.R.4
  • 21
    • 0030147124 scopus 로고    scopus 로고
    • Familial clustering of abdominal visceral fat and total fat mass: the Quebec Family Study
    • Rice T, Perusse L, Bouchard C, Rao DC. Familial clustering of abdominal visceral fat and total fat mass: the Quebec Family Study. Obes Res 1996;4:253-61.
    • (1996) Obes Res , vol.4 , pp. 253-261
    • Rice, T.1    Perusse, L.2    Bouchard, C.3    Rao, D.C.4
  • 23
    • 9644260361 scopus 로고    scopus 로고
    • Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice
    • Almind K, Kahn CR. Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 2004;53:3274-85.
    • (2004) Diabetes , vol.53 , pp. 3274-3285
    • Almind, K.1    Kahn, C.R.2
  • 24
    • 0037872709 scopus 로고    scopus 로고
    • Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
    • Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR. Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 2003;52:1528-34.
    • (2003) Diabetes , vol.52 , pp. 1528-1534
    • Kulkarni, R.N.1    Almind, K.2    Goren, H.J.3    Winnay, J.N.4    Ueki, K.5    Okada, T.6    Kahn, C.R.7
  • 25
    • 0038659916 scopus 로고    scopus 로고
    • Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance
    • Almind K, Kulkarni RN, Lannon SM, Kahn CR. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 2003;52: 1535-43.
    • (2003) Diabetes , vol.52 , pp. 1535-1543
    • Almind, K.1    Kulkarni, R.N.2    Lannon, S.M.3    Kahn, C.R.4
  • 26
    • 49449106657 scopus 로고    scopus 로고
    • The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004)
    • Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, Wylie-Rosett J, Sowers MR. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 2008;168: 1617-24.
    • (2008) Arch Intern Med , vol.168 , pp. 1617-1624
    • Wildman, R.P.1    Muntner, P.2    Reynolds, K.3    McGinn, A.P.4    Rajpathak, S.5    Wylie-Rosett, J.6    Sowers, M.R.7
  • 27
    • 0034961865 scopus 로고    scopus 로고
    • Regional differences in protein production by human adipose tissue
    • Arner P. Regional differences in protein production by human adipose tissue. Biochem Soc Trans 2001;29(Pt 2):72-5.
    • (2001) Biochem Soc Trans , vol.29 , pp. 72-75
    • Arner, P.1
  • 28
    • 33747356154 scopus 로고    scopus 로고
    • Adipose tissue: from lipid storage compartment to endocrine organ
    • Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 2006;55:1537-45.
    • (2006) Diabetes , vol.55 , pp. 1537-1545
    • Scherer, P.E.1
  • 31
    • 84864118287 scopus 로고    scopus 로고
    • Immunological complications of obesity
    • Kanneganti TD, Dixit VD. Immunological complications of obesity. Nat Immunol 2012;13:707-12.
    • (2012) Nat Immunol , vol.13 , pp. 707-712
    • Kanneganti, T.D.1    Dixit, V.D.2
  • 37
    • 84863586953 scopus 로고    scopus 로고
    • Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality
    • Hamer M, Stamatakis E. Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. J Clin Endocrinol Metab 2012;97:2482-8.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2482-2488
    • Hamer, M.1    Stamatakis, E.2
  • 39
    • 74949084667 scopus 로고    scopus 로고
    • Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men
    • Arnlov J, Ingelsson E, Sundstrom J, Lind L. Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 2010;121:230-6.
    • (2010) Circulation , vol.121 , pp. 230-236
    • Arnlov, J.1    Ingelsson, E.2    Sundstrom, J.3    Lind, L.4
  • 40
    • 84896514964 scopus 로고    scopus 로고
    • Risk of myocardial infarction and heart failure among metabolically healthy but obese individuals: HUNT (Nord-Trondelag Health Study), Norway
    • Morkedal B, Vatten LJ, Romundstad PR, Laugsand LE, Janszky I. Risk of myocardial infarction and heart failure among metabolically healthy but obese individuals: HUNT (Nord-Trondelag Health Study), Norway. J Am Coll Cardiol 2014;63:1071-8.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 1071-1078
    • Morkedal, B.1    Vatten, L.J.2    Romundstad, P.R.3    Laugsand, L.E.4    Janszky, I.5
  • 41
    • 84884500573 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: a cohort study
    • Appleton SL, Seaborn CJ, Visvanathan R, Hill CL, Gill TK, Taylor AW, Adams RJ; North West Adelaide Health Study Team. Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: a cohort study. Diabetes Care 2013;36:2388-94.
    • (2013) Diabetes Care , vol.36 , pp. 2388-2394
    • Appleton, S.L.1    Seaborn, C.J.2    Visvanathan, R.3    Hill, C.L.4    Gill, T.K.5    Taylor, A.W.6    Adams, R.J.7
  • 42
    • 84896714517 scopus 로고    scopus 로고
    • Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals
    • Aung K, Lorenzo C, Hinojosa MA, Haffner SM. Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals. J Clin Endocrinol Metab 2014; 99:462-8.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. 462-468
    • Aung, K.1    Lorenzo, C.2    Hinojosa, M.A.3    Haffner, S.M.4
  • 43
    • 84861424380 scopus 로고    scopus 로고
    • Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan
    • Hwang LC, Bai CH, Sun CA, Chen CJ. Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan. Asia Pac J Clin Nutr 2012;21:227-33.
    • (2012) Asia Pac J Clin Nutr , vol.21 , pp. 227-233
    • Hwang, L.C.1    Bai, C.H.2    Sun, C.A.3    Chen, C.J.4
  • 44
    • 84901608827 scopus 로고    scopus 로고
    • Metabolic health is a more important determinant for diabetes development than simple obesity: a 4-year retrospective longitudinal study
    • Rhee EJ, Lee MK, Kim JD, Jeon WS, Bae JC, Park SE, Park CY, Oh KW, Park SW, Lee WY. Metabolic health is a more important determinant for diabetes development than simple obesity: a 4-year retrospective longitudinal study. PLoS One 2014;9:e98369.
    • (2014) PLoS One , vol.9
    • Rhee, E.J.1    Lee, M.K.2    Kim, J.D.3    Jeon, W.S.4    Bae, J.C.5    Park, S.E.6    Park, C.Y.7    Oh, K.W.8    Park, S.W.9    Lee, W.Y.10
  • 45
    • 80053018598 scopus 로고    scopus 로고
    • Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals
    • Voulgari C, Tentolouris N, Dilaveris P, Tousoulis D, Katsilambros N, Stefanadis C. Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. J Am Coll Cardiol 2011;58:1343-50.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 1343-1350
    • Voulgari, C.1    Tentolouris, N.2    Dilaveris, P.3    Tousoulis, D.4    Katsilambros, N.5    Stefanadis, C.6
  • 47
    • 84890308528 scopus 로고    scopus 로고
    • Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-analysis
    • Kramer CK, Zinman B, Retnakaran R. Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-analysis. Ann Intern Med 2013; 159:758-69.
    • (2013) Ann Intern Med , vol.159 , pp. 758-769
    • Kramer, C.K.1    Zinman, B.2    Retnakaran, R.3
  • 48
    • 84890281624 scopus 로고    scopus 로고
    • The myth of healthy obesity
    • Hill JO, Wyatt HR. The myth of healthy obesity. Ann Intern Med 2013;159:789-90.
    • (2013) Ann Intern Med , vol.159 , pp. 789-790
    • Hill, J.O.1    Wyatt, H.R.2
  • 50
    • 11244269558 scopus 로고    scopus 로고
    • Can we identify metabolically healthy but obese individuals (MHO)?
    • Karelis AD, Brochu M, Rabasa-Lhoret R. Can we identify metabolically healthy but obese individuals (MHO)? Diabetes Metab 2004;30:569-72.
    • (2004) Diabetes Metab , vol.30 , pp. 569-572
    • Karelis, A.D.1    Brochu, M.2    Rabasa-Lhoret, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.