Metformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: An in Vitro study

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Kobashigawa, Laura C ^a   Xu, Yan Chun ^a   Padbury, James F ^a   Tseng, Yi Tang ^a   Yano, Naohiro ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIMETHOXY 2 PHENYLQUINOXALINE; CALCIUM ION; COMPOUND C; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOXORUBICIN; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KI 67 ANTIGEN; LACTATE DEHYDROGENASE; METFORMIN; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CARDIOTOXICITY; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS; HEART MUSCLE CELL; HEART PROTECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MYOBLAST; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DRUG EFFECTS; METABOLISM;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; CARDIOTOXICITY; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOXORUBICIN; ENZYME ACTIVATION; HUMANS; METFORMIN; MYOBLASTS, CARDIAC; MYOCYTES, CARDIAC; RATS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84940257402     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104888     Document Type: Article

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