Ferritin heavy chain as main mediator of preventive effect of metformin against mitochondrial damage induced by doxorubicin in cardiomyocytes

Free Radical Biology and Medicine

Volumn 67, Issue , 2014, Pages 19-29

  Asensio Lopez, Mari C ^a,b   Sanchez Mas, Jesus ^a,b   Pascual Figal, Domingo A ^a,b   De Torre, Carlos ^a   Valdes, Mariano ^a,b   Lax, Antonio ^a,b  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

Author keywords

Cardiotoxicity; Doxorubicin; Ferritin; Free radicals; Iron homeostasis; Metformin; Mitochondrial function

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CYTOCHROME C; DOXORUBICIN; FERRITIN; FERRITIN HEAVY CHAIN; IRON; METFORMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; APOFERRITIN; CARDIOTONIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; BIGUANIDE; CYCLOSPORIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DRUG EFFICACY; ENZYME ACTIVATION; HEART MUSCLE CELL; HEART PROTECTION; HEAVY CHAIN; HOMEOSTASIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; NEWBORN; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TUMOR CELL LINE; ADULT; CELL DEATH; CELL PROTECTION; CLINICAL ASSESSMENT; COMPARATIVE STUDY; DETERIORATION; IRON STORAGE; MITOCHONDRIAL DAMAGE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; UPREGULATION;

RATTUS;

ANIMALS; ANIMALS, NEWBORN; ANTIBIOTICS, ANTINEOPLASTIC; APOFERRITINS; APOPTOSIS; CARDIOTONIC AGENTS; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; DNA FRAGMENTATION; DOXORUBICIN; GENE EXPRESSION REGULATION; IRON; METFORMIN; MICE; MITOCHONDRIA; MYOCYTES, CARDIAC; NF-KAPPA B; RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84887976225     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.11.003     Document Type: Article

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