Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 33, 2015, Pages E4556-E4564

  Chen, Yih Wen ^a   Harris, Robert A ^a   Hatahet, Zafer ^b   Chou, Kai Ming ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN STATE UNIVERSITY   (United States)

Author keywords

Adipose tissue; DNA damage; DNA polymerase ; Obesity; Senescence

Indexed keywords

ATM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA POLYMERASE; HISTONE H2AX; INTERLEUKIN 6; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PEPTIDES AND PROTEINS; PROTEIN P21; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM VARIANT PROTEIN; BENZOTHIAZOLE DERIVATIVE; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ETA; GLUCOSE BLOOD LEVEL; PIFITHRIN; REACTIVE OXYGEN METABOLITE; TOLUENE;

ADIPOCYTE; ADIPOSE TISSUE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CONTROLLED STUDY; DNA DAMAGE; FATTY LIVER; GLUCOSE INTOLERANCE; HYPERINSULINEMIA; HYPERLEPTINEMIA; INTRAABDOMINAL FAT; LIPID STORAGE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TISSUE SENESCENCE; UPREGULATION; 3T3 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; CANCER TRANSPLANTATION; CHEMISTRY; COMET ASSAY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; KNOCKOUT MOUSE; MACROPHAGE; MALE; METABOLIC SYNDROME X; METABOLISM; PATHOLOGY; PHYSIOLOGY;

MUS;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BENZOTHIAZOLES; BLOOD GLUCOSE; CELL AGING; COMET ASSAY; DNA DAMAGE; DNA-DIRECTED DNA POLYMERASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOTYPE; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; MACROPHAGES; MALE; METABOLIC SYNDROME X; MICE; MICE, KNOCKOUT; NEOPLASM TRANSPLANTATION; REACTIVE OXYGEN SPECIES; TOLUENE;

EID: 84940184917     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1506954112     Document Type: Article

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