Reduced gene expression levels after chronic exposure to high concentrations of air pollutants

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 780, Issue , 2015, Pages 60-70

  Rossner, Pavel ^a   Tulupova, Elena ^a   Rossnerova, Andrea ^a   Libalova, Helena ^a   Honkova, Katerina ^a   Gmuender, Hans ^b   Pastorkova, Anna ^a   Svecova, Vlasta ^a   Topinka, Jan ^a   Sram, Radim J ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^b GENEDATA AG   (Switzerland)

Author keywords

Air pollution; Chronic exposure; Gene expression profiles; Human health; Particulate matter; Polycyclic aromatic hydrocarbons

Indexed keywords

ATM PROTEIN; BENZENE; BENZO[A]PYRENE; FAS ANTIGEN; GLUTATHIONE TRANSFERASE M1; INTERLEUKIN 1BETA; AIR POLLUTANT;

ADULT; AIR POLLUTANT; AIR POLLUTION; APEX GENE; ARTICLE; ATM GENE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CZECH REPUBLIC; ENVIRONMENTAL EXPOSURE; FAS GENE; GADD45A GENE; GENE; GENE EXPRESSION; GEOGRAPHIC DISTRIBUTION; GSTM1 GENE; HUMAN; IL1B GENE; LONG TERM EXPOSURE; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; PTGS2 GENE; QUANTITATIVE ANALYSIS; RAD21 GENE; REAL TIME POLYMERASE CHAIN REACTION; SEASONAL VARIATION; ADVERSE EFFECTS; CLINICAL TRIAL; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LEUKOCYTE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; SEASON; TOXICITY;

ADULT; AIR POLLUTANTS; CZECH REPUBLIC; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SEASONS;

EID: 84940049917     PISSN: 00275107     EISSN: 18792871     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2015.08.001     Document Type: Article

References (57)

1. Pope C.A., Dockery D.W. Health effects of fine particulate air pollution: lines that connect. J. Air Waste Manage. Assoc. 2006, 56:709-742.
2. Brunekreef B., Holgate S.T. Air pollution and health. Lancet 2002, 360:1233-1242.
3. Valavanidis A., Fiotakis K., Vlachogianni T. Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 2008, 26:339-362.
4. Oberdorster G., Oberdorster E., Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005, 113:823-839.
5. IARC IARC monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Monograph on Some Non-Heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures 2010, IARC, Publications, Lyon, France.
6. IARC IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Chemical Agents and Related Occupations 2012, IARC, Publications, Lyon, France.
7. Gerde P., Muggenburg B.A., Lundborg M., Dahl A.R. The rapid alveolar absorption of diesel soot-adsorbed benzo[a]pyrene: bioavailability, metabolism and dosimetry of an inhaled particle-borne carcinogen. Carcinogenesis 2001, 22:741-749.
8. Demetriou C.A., Raaschou-Nielsen O., Loft S., Moller P., Vermeulen R., Palli D., Chadeau-Hyam M., Xun W.W., Vineis P. Biomarkers of ambient air pollution and lung cancer: a systematic review. Occup. Environ. Med. 2012, 69:619-627.
9. Moller P., Loft S. Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution. Environ. Health Perspect. 2010, 118:1126-1136.
10. Castano-Vinyals G., D'Errico A., Malats N., Kogevinas M. Biomarkers of exposure to polycyclic aromatic hydrocarbons from environmental air pollution. Occup. Environ. Med. 2004, 61:e12.
11. Mateuca R., Lombaert N., Aka P.V., Decordier I., Kirsch-Volders M. Chromosomal changes: induction, detection methods and applicability in human biomonitoring. Biochimie 2006, 88:1515-1531.
12. Rossnerova A., Spatova M., Schunck C., Sram R.J. Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure. Mutagenesis 2011, 26:169-175.
13. Gerlofs-Nijland M.E., van Berlo D., Cassee F.R., Schins R.P., Wang K., Campbell A. Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol. 2010, 7:12.
14. Bai N., Kido T., Kavanagh T.J., Kaufman J.D., Rosenfeld M.E., van Breemen C., van Eeden S.F. Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice. Toxicol. Appl. Pharmacol. 2011, 255:184-192.
15. Xu X., Liu C., Xu Z., Tzan K., Zhong M., Wang A., Lippmann M., Chen L.C., Rajagopalan S., Sun Q. Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicol. Sci. 2011, 124:88-98.
16. Bos I., De Boever P., Emmerechts J., Buekers J., Vanoirbeek J., Meeusen R., Van Poppel M., Nemery B., Nawrot T., Panis L.I. Changed gene expression in brains of mice exposed to traffic in a highway tunnel. Inhal. Toxicol. 2012, 24:676-686.
17. Wild C.P., Scalbert A., Herceg Z. Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk. Environ. Mol. Mutagen. 2013, 54:480-499.
18. Sen B., Mahadevan B., DeMarini D.M. Transcriptional responses to complex mixtures: a review. Mutat. Res. 2007, 636:144-177.
19. Thomson E.M., Vladisavljevic D., Mohottalage S., Kumarathasan P., Vincent R. Mapping acute systemic effects of inhaled particulate matter and ozone: multiorgan gene expression and glucocorticoid activity. Toxicol. Sci. 2013, 135:169-181.
20. Yokota S., Hori H., Umezawa M., Kubota N., Niki R., Yanagita S., Takeda K. Gene expression changes in the olfactory bulb of mice induced by exposure to diesel exhaust are dependent on animal rearing environment. PLoS One 2013, 8:e70145.
21. Maresh J.G., Campen M.J., Reed M.D., Darrow A.L., Shohet R.V. Hypercholesterolemia potentiates aortic endothelial response to inhaled diesel exhaust. Inhal. Toxicol. 2011, 23(1):1-10.
22. Gottipolu R.R., Wallenborn J.G., Karoly E.D., Schladweiler M.C., Ledbetter A.D., Krantz T., Linak W.P., Nyska A., Johnson J.A., Thomas R., Richards J.E., Jaskot R.H., Kodavanti U.P. One-month diesel exhaust inhalation produces hypertensive gene expression pattern in healthy rats. Environ. Health Perspect. 2009, 117:38-46.
23. Pettit A.P., Brooks A., Laumbach R., Fiedler N., Wang Q., Strickland P.O., Madura K., Zhang J., Kipen H.M. Alteration of peripheral blood monocyte gene expression in humans following diesel exhaust inhalation. Inhal. Toxicol. 2012, 24:172-181.
24. Huang Y.C., Schmitt M., Yang Z., Que L.G., Stewart J.C., Frampton M.W., Devlin R.B. Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles. Inhal. Toxicol. 2010, 22:835-846.
25. Strulovici-Barel Y., Omberg L., O'Mahony M., Gordon C., Hollmann C., Tilley A.E., Salit J., Mezey J., Harvey B.G., Crystal R.G. Threshold of biologic responses of the small airway epithelium to low levels of tobacco smoke. Am. J. Respir. Crit. Care Med. 2010, 182:1524-1532.
26. Peretz A., Peck E.C., Bammler T.K., Beyer R.P., Sullivan J.H., Trenga C.A., Srinouanprachnah S., Farin F.M., Kaufman J.D. Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: an exploratory study of healthy human volunteers. Inhal. Toxicol. 2007, 19:1107-1119.
27. Lodovici M., Luceri C., De Filippo C., Romualdi C., Bambi F., Dolara P. Smokers and passive smokers gene expression profiles: correlation with the DNA oxidation damage. Free Radical Biol. Med. 2007, 43:415-422.
28. Holloway J.W., Savarimuthu Francis S., Fong K.M., Yang I.A. Genomics and the respiratory effects of air pollution exposure. Respirology 2012, 17:590-600.
29. Rossner P., Svecova V., Schmuczerova J., Milcova A., Tabashidze N., Topinka J., Pastorkova A., Sram R.J. Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I: bulky DNA adducts. Mutagenesis 2013, 28:89-95.
30. Rossner P., Rossnerova A., Spatova M., Beskid O., Uhlirova K., Libalova H., Solansky I., Topinka J., Sram R.J. Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II: chromosomal aberrations and oxidative stress. Mutagenesis 2013, 28:97-106.
31. Sram R.J., Dostal M., Libalova H., Rossner P., Rossnerova A., Svecova V., Topinka J., Bartonova A. The European Hot Spot of B[a]P and PM2. 5 Exposure-the Ostrava Region, Czech Republic: health research results. ISRN Public Health 2013, 2013:1.
32. Binkova B., Topinka J., Mrackova G., Gajdosova D., Vidova P., Stavkova Z., Peterka V., Pilcik T., Rimar V., Dobias L., Farmer P.B., Sram R.J. Coke oven workers study: the effect of exposure and GSTM1 and NAT2 genotypes on DNA adduct levels in white blood cells and lymphocytes as determined by 32P-postlabelling. Mutat. Res. 1998, 416:67-84.
33. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practival and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B Methodol. 1995, 57:289-300.
34. Huang da W., Sherman B.T., Lempicki R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009, 37:1-13.
35. van Leeuwen D.M., van Herwijnen M.H., Pedersen M., Knudsen L.E., Kirsch-Volders M., Sram R.J., Staal Y.C., Bajak E., van Delft J.H., Kleinjans J.C. Genome-wide differential gene expression in children exposed to air pollution in the Czech Republic. Mutat. Res. 2006, 600:12-22.
36. van Leeuwen D.M., Pedersen M., Hendriksen P.J., Boorsma A., van Herwijnen M.H., Gottschalk R.W., Kirsch-Volders M., Knudsen L.E., Sram R.J., Bajak E., van Delft J.H., Kleinjans J.C. Genomic analysis suggests higher susceptibility of children to air pollution. Carcinogenesis 2008, 29:977-983.
37. De Coster S., van Leeuwen D.M., Jennen D.G., Koppen G., Den Hond E., Nelen V., Schoeters G., Baeyens W., van Delft J.H., Kleinjans J.C., van Larebeke N. Gender-specific transcriptomic response to environmental exposure in Flemish adults. Environ. Mol. Mutagen. 2013, 54:574-588.
38. van Leeuwen D.M., Gottschalk R.W., Schoeters G., van Larebeke N.A., Nelen V., Baeyens W.F., Kleinjans J.C., van Delft J.H. Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studies. Environ. Health Perspect. 2008, 116:1519-1525.
39. Barzilai A., Yamamoto K. DNA damage responses to oxidative stress. DNA Rep. 2004, 3:1109-1115. (Amst).
40. Migliore L., Coppede F. Environmental-induced oxidative stress in neurodegenerative disorders and aging. Mutat. Res. 2009, 674:73-84.
41. Calderon-Garciduenas L., Solt A.C., Henriquez-Roldan C., Torres-Jardon R., Nuse B., Herritt L., Villarreal-Calderon R., Osnaya N., Stone I., Garcia R., Brooks D.M., Gonzalez-Maciel A., Reynoso-Robles R., Delgado-Chavez R., Reed W. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicol. Pathol. 2008, 36:289-310.
42. Malhotra J.D., Kaufman R.J. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?. Antioxid. Redox. Signal. 2007, 9:2277-2293.
43. Deiuliis J.A., Kampfrath T., Zhong J., Oghumu S., Maiseyeu A., Chen L.C., Sun Q., Satoskar A.R., Rajagopalan S. Pulmonary T cell activation in response to chronic particulate air pollution. Am. J. Physiol. Lung Cell Mol. Physiol. 2012, 302:L399-L409.
44. Muller L., Chehrazi C.V., Henderson M.W., Noah T.L., Jaspers I. Diesel exhaust particles modify natural killer cell function and cytokine release. Part Fibre Toxicol. 2013, 10:16. 16.
45. Ren C., Tong S. Health effects of ambient air pollution-recent research development and contemporary methodological challenges. Environ. Health 2008, 7:56.
46. Loomis D., Grosse Y., Lauby-Secretan B., El Ghissassi F., Bouvard V., Benbrahim-Tallaa L., Guha N., Baan R., Mattock H., Straif K. The carcinogenicity of outdoor air pollution. Lancet Oncol. 2013, 14:1262-1263.
47. Abbotts R., Madhusudan S. Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer. Cancer Treat. Rev. 2010, 36:425-435.
48. Shiloh Y., Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 2013, 14:197-210.
49. Feeney K.M., Wasson C.W., Parish J.L. Cohesin: a regulator of genome integrity and gene expression. Biochem. J. 2010, 428:147-161.
50. Roos W.P., Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol. Med. 2006, 12:440-450.
51. Kasza A. IL-1 and EGF regulate expression of genes important in inflammation and cancer. Cytokine 2013, 62:22-33.
52. Bolt H.M., Thier R. Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. Curr. Drug Metab. 2006, 7:613-628.
53. Rosemary Siafakas A., Richardson D.R. Growth arrest and DNA damage-45 alpha (GADD45alpha). Int. J. Biochem. Cell Biol. 2009, 41:986-989.
54. Rossner P., Uhlirova K., Beskid O., Rossnerova A., Svecova V., Sram R.J. Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic. Mutat. Res. 2011, 713:76-82.
55. Whitney A.R., Diehn M., Popper S.J., Alizadeh A.A., Boldrick J.C., Relman D.A., Brown P.O. Individuality and variation in gene expression patterns in human blood. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:1896-1901.
56. De Jong S., Neeleman M., Luykx J.J., ten Berg M.J., Strengman E., Den Breeijen H.H., Stijvers L.C., Buizer-Voskamp J.E., Bakker S.C., Kahn R.S., Horvath S., Van Solinge W.W., Ophoff R.A. Seasonal changes in gene expression represent cell-type composition in whole blood. Hum. Mol. Genet. 2014, 23:2721-2728.
57. Jaworowski Z. Radiation hormesis-a remedy for fear. Hum. Exp. Toxicol. 2010, 29:263-270.