Porous hydroxyapatite for drug delivery

Hydroxyapatite (HAp) for Biomedical Applications

Volumn , Issue , 2015, Pages 129-142

  Loca, D ^a   Locs, J ^a   Dubnika, A ^a   Zalite, V ^a   Berzina Cimdina, L ^a  

^a RIGA TECHNICAL UNIVERSITY   (Latvia)

Author keywords

Calcium phosphates; Drug delivery; Porous hydroxyapatite

Indexed keywords

BIOCOMPATIBILITY; BONE; CALCIUM; CALCIUM PHOSPHATE; DRUG DELIVERY; DRUG DOSAGE; DRUG THERAPY; HYDROXYAPATITE; TISSUE;

ACTIVE SUBSTANCE; CONTROLLED RELEASE; DRUG DELIVERY SYSTEM; INTERCONNECTIVITY; OSTEOCONDUCTIVITY; POROUS HYDROXYAPATITE; POROUS STRUCTURES; SITE-SPECIFIC DRUG DELIVERIES;

CONTROLLED DRUG DELIVERY;

EID: 84940035769     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978178242033000009-2     Document Type: Chapter

References (90)

1. Bach L.G., Islam M.R., Vo T.-S., Kim S.-K., Lim K.T. Poly(allyl methacrylate) functionalized hydroxyapatite nanocrystals via the combination of surface-initiated RAFT polymerization and thiolene protocol: a potential anticancer drug nanocarrier. J. Colloid. Interf. Sci. 2013, 394:132-140.
2. Baldini N., De Sanctis M., Ferrari M. Deproteinized bovine bone in periodontal and implant surgery. Dent. Mater. 2011, 27:61-70.
3. Baradari H., Damia C., Dutreih-Colas M., Laborde E., Pecout N., Champion E., Chulia D., Viana M. Calcium phosphate porous pellets as drug delivery systems: effect of drug carrier composition on drug loading and in vitro release. J. Eur. Ceram. Soc. 2012, 32:2679-2690.
4. Bohner M. Physical and chemical aspects of calcium phosphates used in spinal surgery. Eur. Spine J. 2001, 10:114-121.
5. Bretcanu O., Samaille C., Boccaccini A.R. Simple methods to fabricate Bioglass®-derived glass-ceramic scaffolds exhibiting porosity gradient. J. Mater. Sci. 2008, 43:27-34.
6. Brothers A.H., Dunand D.C. Density-graded cellular aluminum. Adv. Eng. Mater. 2006, 8:805-809.
7. Burgos A.E., Belchior J.C., Sinisterra R.D. Controlled release of rhodium (II) carboxylates and their association complexes with cyclodextrins from hydroxyapatite matrix. Biomaterials 2002, 23:2519-2526.
8. Chai F., Hornez J.C., Blanchemain N., Neut C., Descamps M., Hildebrand H.F. Antibacterial activation of hydroxyapatite (HA) with controlled porosity by different antibiotics. Biomol. Eng. 2007, 24:510-514.
9. Chiang Z.C., Yu S.H., Chao A.C., Dong G.C. Preparation and characterization of dexamethasone-immobilized chitosan scaffold. J. Biosci. Bioeng. 2012, 113(5):654-660.
10. Cichocki F.R., Trumble K.P., Rödel J. Tailored porosity gradients via colloidal infiltration of compression-molded sponges. J. Am. Ceram. Soc. 1998, 81:1661-1664.
11. Čolovič B., Pašalic S., Jokanovic V. Influence of hydroxyapatite pore geometry on tigecycline release kinetics. Ceram. Int. 2012, 38:6181-6189.
12. Cosijns A., Vervaet C., Luyten J., Mullens S., Siepmann F., Van Hoorebeke L., Masschaele B., Cnudde V., Remon J.P. Porous hydroxyapatite tablets as carriers for low-dosed drugs. Eur. J. Pharm. Biopharm. 2007, 67:498-506.
13. Cyster L.A., Grant D.M., Howdle S.M., Rose F.R.A.J., Irvine D.J., Freeman D., Scotchford C.A., Shakesheff K.M. The influence of dispersant concentration on the pore morphology of hydroxyapatite ceramics for bone tissue engineering. Biomaterials 2005, 26:697-702.
14. Descamps M., Hornez J.C., Leriche A. Manufacture of hydroxyapatite beads for medical applications. J. Eur. Ceram. Soc. 2009, 29:369-375.
15. Deville S., Saiz E., Tomsia A.P. Freeze casting of hydroxyapatite scaffolds for bone tissue engineering. Biomaterials 2006, 27:5480-5489.
16. Dorozhkin S.V. Calcium orthophosphates in nature, biology and medicine. Materials 2009, 2:399-498.
17. Dorozhkin S.V. Biocomposites and hybrid biomaterials based on calcium orthophosphates. Biomatter 2011, 1:1-51.
18. Dubnika A., Loca D., Berzina-Cimdina L. Functionalized hydroxyapatite scaffolds coated with sodium alginate and chitosan for controlled drug delivery. Proc. Estonian Acad. Sci. 2012, 61(3):193-199.
19. Epple M., Baeuerlein E. Handbook of Biomineralization. Medical and Clinical Aspects 2007, Wiley-VCH Verlag GmbH & Co, KGaA, Germany.
20. Fournier E., Passirani C., Montero-Menei C.N., Benoit J.P. Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility. Biomaterials 2003, 24:3311-3331.
21. Guo Y.P., Yao Y.B., Guo Y.J., Ning C.Q. Hydrothermal fabrication of mesoporous carbonated hydroxyapatite microspheres for a drug delivery system. Micropor. Mesopor. Mat. 2012, 155:245-251.
22. Habraken W.J.E.M., Wolke J.G.C., Jansen J.A. Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering. Adv. Drug Deliver. Rev. 2007, 59:234-248.
23. 3 composite structures for bone ingrowth. J. Mater. Sci. Mater. Med. 2007, 18:1817-1824.
24. Hong M.H., Son J.-S., Han K.-M., Oh D.S., Lee Y.-K. Drug-loaded porous spherical hydroxyapatite granules for bone regeneration. Mater. Sci. Mater. Med. 2011, 22:349-355.
25. Ishihara S., Matsumoto T., Onoki T., Uddin M.H., Sohmura T., Nakahira A. Regulation of the protein-loading capacity of hydroxyapatite by mercaptosuccinic acid modification. Acta Biomater. 2010, 6:830-835.
26. Itokazu M., Esaki M., Yamamoto K., Tanemori T., Kasai T. Local drug delivery system using ceramics: vacuum method for impregnating a chemotherapeutic agent into a porous hydroxyapatite block. J. Mater. Sci. Mater. Med. 1999, 10:249-252.
27. Jinawath S., Pongkao D., Yoshimura M. Hydrothermal synthesis of hydroxyapatite from natural source. J. Mater. Sci. Mater. Med. 2002, 13:491-494.
28. Jo I.H., Shin K.H., Soon Y.M., Koh Y.H., Lee J.H., Kim H.E. Highly porous hydroxyapatite scaffolds with elongated pores using stretched polymeric sponges as novel template. Mater. Lett. 2009, 63:1702-1704.
29. Kim H.W., Knowles J.C., Kim H.E. Hydroxyapatite/poly(e-caprolactone) composite coatings on hydroxyapatite porous bone scaffold for drug delivery. Biomaterials 2004, 25:1279-1287.
30. Kim J.H., Lee J.H., Yang T.Y., Yoon S.Y., Kim B.K., Park H.C. TBA-based freeze/gel casting of porous hydroxyapatite scaffolds. Ceram. Int. 2011, 37:2317-2322.
31. Kolk A., Handschel J., Drescher W., Rothamel D., Kloss F., Blessmann M., Heiland M., Wolff K.-D., Smeets R. Current trends and future perspectives of bone substitute materials-from space holders to innovative biomaterials. J. Cranio Maxill Surg. 2012, 40:706-718.
32. Laird D.F., Mucalo M.R., Dias G.J. Vacuum-assisted infiltration of chitosan or polycaprolactone as a structural reinforcement for sintered cancellous bovine bone graft. J. Biomed. Mater. Res. A 2012, 100:2581-2592.
33. Landi E., Valentini F., Tampieri A. Porous hydroxyapatite/gelatine scaffolds with ice-designed channel-like porosity for biomedical applications. Acta. Biomat. 2008, 4:1620-1626.
34. Lepretre S., Chai F., Hornez J.C., Vermet G., Neut C., Descamps M., Hildebrand H.F., Martel B. Prolonged local antibiotics delivery from hydroxyapatite functionalised with cyclodextrin polymers. Biomaterials 2009, 30:6086-6093.
35. Li X.Y., Nan K.H., Shi S., Chen H. Preparation and characterization of nano-hydroxyapaitite/chitosan cross-linking composite membrane intended for tissue engineering. Int. J. Biol. Macromol. 2012, 50:43-49.
36. 2O addition. Biomaterials 1999, 20:475-484.
37. Lin K., Liu P., Wei L., Zou Z., Zhang W., Qian Y., Shen Y., Chang J. Strontium substituted hydroxyapatite porous microspheres: surfactant-free hydrothermal synthesis, enhanced biological response and sustained drug release. Chem. Eng. J. 2013, 222:49-59.
38. Loca D., Locs J., Gulbis J., Salma I., Berzina-Cimdina L. Lidocaine loaded Ca/P scaffolds for bone regeneration and local drug delivery. Adv. Mat. Res. 2011, 222:289-292.
39. Loca D., Locs J., Salma K., Gulbis J., Salma I., Berzina-Cimdina L. Porous hydroxyapatite bioceramic scaffolds for drug delivery and bone regeneration. IOP Conf. Ser. Mater. Sci. Eng. 2011, 18:192019.
40. Loca D., Dubnika A., Reinis A., Romancikova N. In vitro evaluation of osteoblast cell behavior and antimicrobial properties of biphasic calcium phosphate ceramics. IFMBE Proc. 2013, 38:186-190.
41. Locs J., Zalite V., Berzina-Cimdina L., Sokolova M. Ammonium hydrogen carbonate provided viscous slurry foaming-a novel technology for the preparation of porous ceramics. J. Eur. Ceram. Soc. 2013, In Press. 10.1016/j.jeurceramsoc.2013.06.010.
42. Lombardi M., Palmero P., Haberko K., Pyda W., Montanaro L. Processing of a natural hydroxyapatite powder: from powder optimization to porous bodies development. J. Eur. Ceram. Soc. 2011, 31:2513-2518.
43. Maniya N.H., Patel S.R., Murthy Z.V.P. Electrochemical preparation of microstructured porous silicon layers for drug delivery applications. Superlattice Microst. 2013, 55:144-150.
44. Manzano M., Vallet-Regi M. Revisiting bioceramics: bone regenerative and local drug delivery systems. Prog. Solid State Ch. 2012, 40:17-30.
45. Miao X., Sun D. Graded/gradient porous biomaterials. Materials 2010, 3:26-47.
46. Miao X., Tan D.M., Li J., Xiao Y., Crawford R. Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid). Acta. Biomat. 2008, 4:638-645.
47. Mizushima Y., Ikoma T., Tanaka J., Hoshi K., Ishihara T., Ogawa Y., Ueno A. Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs. J. Control. Release 2006, 110(2):260-265.
48. Nascimento D., Gerhardt de Oliveira M., Meurer E., Meurer M.I., Lopes da Silva J.V., Santa-Bárbara A. Dimensional error in selective laser sintering and 3D-printing of models for craniomaxillary anatomy reconstruction. J. Cranio Maxill Surg. 2008, 36:443-449.
49. Netz D.J.A., Sepulveda P., Pandolfelli V.C., Spadaro A.C.C., Alencastre J.B., Bentley M.V.L.B., Marchetti J.M. Potential use of gelcasting hydroxyapatite porous ceramic as an implantable drug delivery system. Int. J. Pharm. 2001, 213:117-125.
50. Oner M., Yetiz E., Ay E., Uysal U. Ibuprofen release from porous hydroxyapatite tablets. Ceram. Int. 2011, 37:2117-2125.
51. Ooia C.Y., Hamdia M., Ramesh S. Properties of hydroxyapatite produced by annealing of bovine bone. Ceram. Int. 2007, 33:1171-1177.
52. Padilla S., Vallet-Regí M., Ginebra M.P., Gil F.J. Processing and mechanical properties of hydroxyapatite pieces obtained by the gelcasting method. J. Eur. Ceram. Soc. 2005, 25:375-383.
53. Palazzo B., Sidoti M.C., Roveri N., Tampieri A., Sandri M., Bertolazzi L., Galbusera F., Dubini G., Vena P., Contro R. Controlled drug delivery from porous hydroxyapatite grafts: an experimental and theoretical approach. Mat. Sci. Eng. C 2005, 25:207-213.
54. Paul W., Sharma C.P. Development of porous spherical hydroxyapatite granules: application towards protein delivery. J. Mater. Sci. Mater. Med. 1999, 10:383-388.
55. Pelss J., Loca D., Berzina-Cimdina L., Locs J., Lakevics V. Release of anticancer drug doxorubicin from biodegradable polymer coated porous hydroxyapatite scaffolds. Adv. Mat. Res. 2011, 284-286:1770-1773.
56. Pérez R.A., Won J.-E., Knowles J.C., Kim H.-W. Naturally and synthetic smart composite biomaterials for tissue regeneration. Adv. Drug Deliv. Rev. 2013, 65:471-496. 10.1016/j.addr.2012.03.009.
57. Potoczek M., Zima A., Paszkiewicz Z., Ślósarczyk A. Manufacturing of highly porous calcium phosphate bioceramics via gel-casting using agarose. Ceram. Int. 2009, 35:2249-2254.
58. Ramay H.R., Zhang M. Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods. Biomaterials 2003, 24:3293-3302.
59. Roy D.M., Linnehan S.K. Hydroxyapatite formed from coral skeletal carbonate by hydrothermal exchange. Nature 1974, 246:220-222.
60. Santos C., Rovath C.F., Franke R.-P., Almeida M.M., Costa M.E.V. Spray-dried hydroxyapatiet-5-fluorouracil granules as a chemotherapeutic delivery system. Ceram. Int. 2009, 35:509-513.
61. Serzane R., Locs J., Berzina-Cimdina L., Sadretdinovs R. Development of porous ceramics by lycopodium using uniaxial pressing and sintering. Process. Appl. Ceram. 2010, 4:231-235.
62. Son J.S., Appleford M., Ong J.L., Wenke J.C., Kim J.M., Choi S.H., Oh D.S. Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres. J. Control. Release 2011, 153:133-140.
63. Swain S.K., Bhattacharyya S., Sarkar D. Preparation of porous scaffold from hydroxyapatite powders. Mater. Sci. Eng. 2011, 31:1240-1244.
64. Szymura-Oleksiak J., Ślósarczyk A., Cios A., Mycek B., Paszkiewicz Z., Szklarczyk S., Stankiewicz D. The kinetics of pentoxifylline release in vivo from drug-loaded hydroxyapatite implants. Ceram. Int. 2001, 27(7):767-772.
65. Taha M., Chai F., Blanchemain N., Goube M., Martel B., Hildebrand H.F. Validating the poly-cyclodextrins based local drug delivery system on plasma-sprayed hydroxyapatite coated orthopedic implant with toluidine blue O. Mater. Sci. Eng. C 2013, 33(5):2639-2647. http://dx.doi.org/10.1016/j.msec.2013.02.022.
66. Tamai N., Myoui A., Tomita T., Nakase T., Tanaka J., Ochi T., Yoshikawa H. Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo. J. Biomed. Mater. Res. 2002, 59:110-117.
67. Tampieri A., Celotti G., Sprio S., Delcogliano A., Franzese S. Porosity-graded hydroxyapatite ceramics to replace natural bone. Biomaterials 2001, 22:1365-1370.
68. Tang R., Hass M., Wu W., Gulde S., Nacollas G.H. Constant composition dissolution of mixed phases II. Selective dissolution of calcium phosphates. J. Colloid. Interf. Sci. 2003, 260:379-384.
69. Tomoda K., Ariizumi H., Nakaji T., Makino K. Hydroxyapatite particles as drug carriers for proteins. Colloid. Surf. B 2010, 76:226-235.
70. Venkatasubbu G.D., Ramasamy S., Avadhani G.S., Ramakrishnan V., Kumar J. Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. Powder Technol. 2013, 235:437-442.
71. 2O. J. Crystal Growth 1990, 104:820-832.
72. Walsh P.J., Buchanan F.J., Dring M., Maggs C., Bell S., Walker G.M. Low-pressure synthesis and characterisation of hydroxyapatite derived from mineralize red algae. Chem. Eng. J. 2008, 137:173-179.
73. Wang S., Wang X., Xu H., Abe H., Tan Z., Zhao Y., Guo J., Naito M., Ichikawa H., Fukumori Y. Towards sustained delivery of small molecular drugs using hydroxyapatite microspheres as the vehicle. Adv. Powder Technol. 2010, 21:268-272.
74. Wei L., Cai C., Lin J., Wang L., Zhang X. Degradation controllable biomaterials constructed from lysozyme-loaded Ca-alginate microparticle/chitosan composites. Polymer 2011, 52:5139-5148.
75. Werner J., Linner-Krčmar B., Friess W., Greil P. Mechanical properties and in vitro cell compatibility of hydroxyapatite ceramics with graded pore structure. Biomaterials 2002, 23:4285-4294.
76. Wu X., Song X., Li D., Liu J., Zhang P., Chen X. Preparation of mesoporous nano-hydroxyapatite using a surfactant template method for protein delivery. J. Bionic Eng. 2012, 9(2):224-233.
77. Yang P., Quan Z., Li C., Kang X., Lian H., Lin J. Bioactive, luminescent and mesoporous europium-doped hydroxyapatite as a drug carrier. Biomaterials 2008, 29:4341-4347.
78. Ye F., Guo H., Zhang H., He X. Polymeric micelle-templated synthesis of hydroxyapatite hollow nanoparticles for a drug delivery system. Acta Biomater. 2010, 6(6):2212-2218.
79. Yunos D.M., Bretcanu O. Polymer-bioceramics composites for tissue engineering scaffolds. J. Mater. Sci. 2008, 43:4433-4442.
80. Zalite V., Loca D., Locs J., Berzina-Cimdina L. Porous bioceramic bone grafts for drug immobilization. Eur. Cells Mater. 2010, 20:280.
81. Zalite V., Locs J., Vempere D., Berzina-Cimdina L. The effect of pore forming agent particle size on the porosity, microstructure and in vitro studies of hydroxyapatite ceramics. Key Eng. Mat. 2012, 493-494:277-280.
82. Zhang Y., Zuo K., Zeng Y.P. Effects of gelatin addition on the microstructure of freeze-cast porous hydroxyapatite ceramics. Ceram. Int. 2009, 35:2151-2154.
83. Zhang C., Li C., Huang S., Hou Z., Cheng Z., Yang P., Peng C., Lin J. Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery. Biomaterials 2010, 2010(31):3374-3383.
84. Zhang Y., Zhou K., Bao Y., Zhang D. Effects of rheological properties on ice-templated porous hydroxyapatite ceramics. Mater. Sci. Eng. C 2013, 33:340-346.
85. Zhao J., Duan K., Zhang J.W., Guo L.Y., Weng J. Preparation of highly interconnected porous hydroxyapatite scaffolds by chitin gel-casting. Mater. Sci. Eng. C 2011, 31:697-701.
86. Zhao K., Tang Y.F., Qin Y.S., Luo D.F. Polymer template fabrication of porous hydroxyapatite scaffolds with interconnected spherical pores. J. Eur. Ceram. Soc. 2011, 31:225-229.
87. Zhao K., Tang Y.-F., Qin Y.-S., Wei J.-Q. Porous hydroxyapatite ceramics by ice templating: freezing characteristics and mechanical properties. Ceram. Int. 2011, 37:635-639.
88. Zhao Q., Wang T., Wang J., Zheng L., Jiang T., Cheng G., Wang S. Template-directed hydrothermal synthesis of hydroxyapatite as a drug delivery system for the poorly water-soluble drug carvedilol. Appl. Surf. Sci. 2011, 257(23):10126-10133.
89. Zhou K., Zhang Y., Zhang D., Zhang X., Li Z., Liu G., Button T.W. Porous hydroxyapatite ceramics fabricated by an ice-templating method. Scripta. Mater. 2011, 64:426-429.
90. Zuo K.H., Zeng Y., Jiang D. Effect of cooling rate and polyvinyl alcohol on the morphology of porous hydroxyapatite ceramics. Mater. Design 2010, 31:3090-3094.