Towards sustained delivery of small molecular drugs using hydroxyapatite microspheres as the vehicle

Advanced Powder Technology

Volumn 21, Issue 3, 2010, Pages 268-272

  Wang, Shaoning ^a   Wang, Xiaoyun ^a   Xu, Hui ^a   Abe, Hiroya ^b   Tan, Zhenquan ^b   Zhao, Yanqiu ^a   Guo, Jianbo ^a   Naito, Makio ^b   Ichikawa, Hideki ^c   Fukumori, Yoshinobu ^c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b OSAKA UNIVERSITY   (Japan)

^c KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Doxycycline hydrochloride; Hydroxyapatite microspheres; PLGA coating; Sustained drug delivery

Indexed keywords

ADSORPTION KINETICS; ADSORPTION/DESORPTION; BURST RELEASE; CRITICAL CONCENTRATION; DOXYCYCLINE HYDROCHLORIDE; DRUG CONCENTRATION; DRUG RELEASE; DRUG SOLUTIONS; EMULSION-SOLVENT EVAPORATION METHOD; FREUNDLICH MODELS; IN-VITRO; MODEL DRUGS; PLGA COATING; RELEASE PROFILES; SUSTAINED DRUG DELIVERY; SUSTAINED RELEASE; WATER SOLUBLE DRUGS;

ADSORPTION; APATITE; COATINGS; DESORPTION; DRUG DELIVERY; DRUG PRODUCTS; EMULSIFICATION; HYDROXYAPATITE; MATHEMATICAL MODELS; MICROSPHERES;

HYDROCHLORIC ACID;

EID: 77955611821     PISSN: 09218831     EISSN: 15685527     Source Type: Journal    
DOI: 10.1016/j.apt.2009.12.001     Document Type: Article

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