Porous hydroxyapatite tablets as carriers for low-dosed drugs

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 67, Issue 2, 2007, Pages 498-506

  Cosijns, A ^a   Vervaet, C ^a   Luyten, J ^b   Mullens, S ^b   Siepmann, F ^c   Van Hoorebeke, L ^a   Masschaele, B ^a   Cnudde, V ^a   Remon, J P ^a  

^a GHENT UNIVERSITY   (Belgium)

^b FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^c UNIV LILLE   (France)

Author keywords

Hydroxyapatite; Low dosed drugs; Modified gelcasting technique; Porous tablet; Sintering

Indexed keywords

DRUG CARRIER; FLAVINE MONONUCLEOTIDE; HYDROXYAPATITE; METOPROLOL TARTRATE; MICROCRYSTALLINE CELLULOSE; SORBITOL; STARCH;

AQUEOUS SOLUTION; ARTICLE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG MANUFACTURE; DRUG PENETRATION; DRUG RELEASE; LOW DRUG DOSE; PHARMACEUTICAL ENGINEERING; POROSITY; SINTER TEMPERATURE; SINTER TIME; TABLET COMPRESSION; TABLET FORMULATION; TABLET FRIABILITY; TABLET MATRIX; TABLET PROPERTY; TABLET SURFACE;

CHEMISTRY, PHARMACEUTICAL; DIFFUSION; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DURAPATITE; GELS; METOPROLOL; MICROSCOPY, ELECTRON, SCANNING; MODELS, STATISTICAL; PARTICLE SIZE; PHOSPHATES; POROSITY; RIBOFLAVIN; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS;

EID: 34547763243     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.02.018     Document Type: Article

References (23)

1. Venables H.J., and Wells J.I. Powder mixing. Drug Dev. Ind. Pharm. 27 (2001) 599-612
2. Vromans H., Poels-Janssen H.G.M., and Egermann H. Effects of high-shear granulation on granulate homogeneity. Pharm. Dev. Tech. 4 (1999) 297-303
3. Jarcho M. Biomaterial aspects of calcium phosphates - properties and applications. Dent. Clin. North Am. 30 (1986) 25-47
4. Itokazu M., Esaki M., Yamamoto K., Tanemori T., and Kasai T. Local drug delivery system using ceramics: vacuum method for impregnating a chemotherapeutic agent into a porous hydroxyapatite block. J. Mater. Sci.: Mater. Med. 10 (1999) 249-252
5. Slosarczyk A., Szymura-Oleksiak J., and Mycek B. The kinetics of pentoxifylline release from drug-loaded hydroxyapatite implants. Biomaterials 21 (2000) 1215-1221
6. Engin N.O., and Tas A.C. Manufacture of macroporous calcium hydroxyapatite bioceramics. J. Eur. Ceram. Soc. 19 (1999) 2569-2572
7. Jarcho M. Calcium-phosphate ceramics as hard tissue prosthetics. Clin. Orthop. Rel. Res. (1981) 259-278
8. Cnudde V., Cnudde J.P., Dupuis C., and Jacobs P.J.S. X-ray micro-CT used for the localization of water repellents and consolidants inside natural building stones. Mater. Character. 53 (2004) 259-271
9. Vergnaud J.M. In: Vergnaud J.M. (Ed). Controlled Drug Release of Oral Dosage Forms (1993), Ellis Horwood Limited, Chichester
10. Omatete O.O., Janney M.A., and Strehlow R.A. Gelcasting - A new ceramic forming process. Am. Ceram. Soc. Bul. 70 (1991) 1641-1649
11. Sepulveda P., and Binner J.G.P. Processing of cellular ceramics by foaming and in situ polymerisation of organic monomers. J. Eur. Ceram. Soc. 19 (1999) 2059-2066
12. Mouazer R., Thijs I., Mullens S., and Luyten J. SiC foams produced by gel casting: Synthesis and characterization. Adv. Eng. Mat. 6 (2004) 340-343
13. Millan A.J., Nieto M.I., and Moreno R. Aqueous gel-forming of silicon nitride using carrageenans. J. Am. Ceram. Soc. 84 (2001) 62-64
14. Luyten J., Mullens S., Cooymans J., De Wilde A.M., and Thijs I. New processing techniques of ceramic foams. Adv. Eng. Mat. 5 (2003) 715-718
15. Raynaud S., Champion E., and Bernache-Assollant D. Calcium phosphate apatites with variable Ca/P atomic ratio II. Calcination and sintering. Biomaterials 23 (2002) 1073-1080
16. Bernache-Assollant D., Ababou A., Champion E., and Heughebaert M. Sintering of calcium phosphate hydroxyapatite Ca-10(PO4)(6)(OH)(2) - I. Calcination and particle growth. J. Eur. Ceram. Soc. 23 (2003) 229-241
17. Muralithran G., and Ramesh S. The effects of sintering temperature on the properties of hydroxyapatite. Cream. Int. 26 (2000) 221-230
18. Raynaud S., Champion E., Bernache-Assollant D., and Thomas P. Calcium phosphate apatites with variable Ca/P atomic ratio I. Synthesis, characterisation and thermal stability of powders. Biomaterials 23 (2002) 1065-1072
19. Barnes G.T., and Gentle I.R. Interfacial Science (2005), Oxford University Press Inc, NewYork
20. Netz D.J.A., Sepulveda P., Pandolfelli V.C., Spadaro A.C.C., Alencastre J.B., Bentley M., and Marchetti J.M. Potential use of gelcasting hydroxyapatite porous ceramic as an implantable drug delivery system. Int. J. Pharm. 213 (2001) 117-125
21. Byrne R.S., and Deasy P.B. Use of commercial porous ceramic particles for sustained drug delivery. Int. J. Pharm. 246 (2002) 61-73
22. Tung I.C. In-vitro drug-release of antibiotic-loaded porous hydroxyapatite cement. Artif. Cells Blood Substit. Immobil. Biotechnol. 23 (1995) 81-88
23. Ginebra M.P., Traykova T., and Planell J.A. Calcium phosphate cements: Competitive drug carriers for the musculoskeletal system?. Biomaterials 27 (2006) 2171-2177