Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs

Journal of Controlled Release

Volumn 110, Issue 2, 2006, Pages 260-265

  Mizushima, Yutaka ^a   Ikoma, Toshiyuki ^b   Tanaka, Jyunzo ^b   Hoshi, Keiko ^c   Ishihara, Tsutomu ^a   Ogawa, Yasuaki ^a   Ueno, Akinori ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Degradation; Drug delivery; Hydroxyapatite; Lipophilic drug; Release kinetics

Indexed keywords

BIODEGRADATION; DEGRADATION; HYDROXYAPATITE; POROUS MATERIALS; PROTEINS; REINFORCEMENT;

DRUG CARRIER; DRUG DELIVERY; LIPOPHILIC DRUG; RELEASE KINETICS;

DRUG DOSAGE;

ALPHA INTERFERON; CYCLOSPORIN A; DRUG CARRIER; HUMAN SERUM ALBUMIN; HYDROXYAPATITE; OIL; PROTEIN; TESTOSTERONE ENANTATE; TESTOSTERONE PROPIONATE; ZINC;

ANIMAL TISSUE; ARTICLE; DRUG ADSORPTION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEMALE; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; POROSITY; PRIORITY JOURNAL; SPRAY DRYING; SUSTAINED DRUG RELEASE;

ANIMALS; BIOCOMPATIBLE MATERIALS; CHEMISTRY, PHYSICAL; CONTRACEPTIVE AGENTS, MALE; CYCLOSPORINE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DURAPATITE; FEMALE; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE I, RECOMBINANT; LIPIDS; MALE; MICE; MICROSCOPY, ELECTRON, SCANNING; NANOSTRUCTURES; POROSITY; PROTEINS; RATS; RATS, WISTAR; SKIN; TESTOSTERONE;

EID: 29244464834     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.09.051     Document Type: Article

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