Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 41, 2013, Pages 16480-16485

  Yang, Yu Hsuan Carol ^a   Manning Fox, Jocelyn E ^b   Zhang, Kevin L ^a   MacDonald, Patrick E ^b   Johnson, James D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Glucose metabolism; Intracellular calcium signaling; Programmed cell death

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 12; CASPASE 3; CASPASE 7; F ACTIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 27; PALMITIC ACID; PROTEIN P53; ROUNDABOUT RECEPTOR; SLIT PROTEIN; SLIT2 PROTEIN; THAPSIGARGIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

GLUCOSE METABOLISM; INTRACELLULAR CALCIUM SIGNALING; PROGRAMMED CELL DEATH;

ACTINS; ANALYSIS OF VARIANCE; ANIMALS; BENZIMIDAZOLES; CALCIUM; CELL SURVIVAL; DIABETES MELLITUS; ENDOPLASMIC RETICULUM; GLYCOPROTEINS; HUMANS; IMMUNOBLOTTING; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84885332704     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214312110     Document Type: Article

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