Adiponectin-induced inhibition of intrinsic and extrinsic apoptotic pathways protects pancreatic β-cells against apoptosis

Hormone and Metabolic Research

Volumn 45, Issue 8, 2013, Pages 561-566

  Jian, L ^a   Su, Y X ^a   Deng, H C ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

adiponectin; apoptosis; caspase; diabetes; lentivirus

Indexed keywords

ADIPONECTIN; CASPASE 3; CASPASE 8; CASPASE 9; CHOLESTEROL; ENHANCED GREEN FLUORESCENT PROTEIN; GLUCOSE; LENTIVIRUS VECTOR; RECOMBINANT ADIPONECTIN; RECOMBINANT PROTEIN; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL PROTECTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; LENTIVIRINAE; LIPID DIET; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; VIRAL GENE DELIVERY SYSTEM;

ADIPONECTIN; ANIMALS; APOPTOSIS; CASPASES; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; TRIGLYCERIDES;

LENTIVIRUS; MUS;

EID: 84880513946     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1341500     Document Type: Article

References (22)

1. Bonner-Weir S. Perspective: Postnatal pancreatic beta cell growth. Endocrinology: 2000; 141 1926 1929 (Pubitemid 32274338)
2. Ulukayal E., Acilan C., Yilmaz Y. Apoptosis: why and how does it occur in biology? Cell Biochem Funct: 2011; 29 468 480
3. Sayers T. J. Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol Immunother: 2011; 60 1173 1180
4. Ferrín G., Linares C. I., Muntané J. Mitochondrial drug targets in cell death and cancer. Curr Pharm Des: 2011; 17 2002 2016
5. Niu K., Asada M., Okazaki T., Yamanda S., Ebihara T., Guo H., Zhang D., Nagatomi R., Arai H., Kohzuki M., Ebihara S. Adiponectin pathway attenuates malignant mesothelioma cell growth. Am J Respir Cell Mol Biol: 2011; 46 515 523
6. Zhang D., Guo M., Zhang W., Lu X. Y. Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3b (GSK-3b)/b-catenin signaling cascade. J Biol Chem: 2011; 286 44913 44920
7. Zhao H. Y., Zhao M., Yi T. N., Zhang J. Globular adiponectin protects human umbilical vein endothelial cells against apoptosis through adiponectin receptor 1/adenosine monophosphate-activated protein kinase pathway. Chin Med J (Engl): 2011; 124 2540 2547
8. Wijesekara N., Krishnamurthy M., Bhattacharjee A., Suhail A., Sweeney G., Wheeler M. B. Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion. J Biol Chem: 2010; 285 33623 33631
9. Rakatzi I., Mueller H., Ritzeler O., Tennagels N., Eckel J. Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1. Diabetologia: 2004; 47 249 258 (Pubitemid 38315361)
10. Lin P., Chen L., Li D., Liu J., Yang N., Sun Y., Xu Y., Fu Y., Hou X. Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip. Tohoku J Exp Med: 2009; 217 59 65
11. Srinivasan K., Ramarao P. Animal models in type 2 diabetes research: An overview. Indian J Med Res: 2007; 125 451 472 (Pubitemid 46805458)
12. Dropulić B. Lentiviral vectors: their molecular design, safety, and use in laboratory and preclinical research. Hum Gene Ther: 2011; 22 649 657
13. Khare R., Chen C. Y., Weaver E. A., Barry M. A. Advances and future challenges in adenoviral vector pharmacology and targeting. Curr Gene Ther: 2011; 11 241 258
14. Satoh H., Nguyen M. T., Trujillo M., Nguyen A., Trujillo M., Imamura T., Usui I., Scherer P. E., Olefsky J. M. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes: 2005; 54 1304 1313 (Pubitemid 40586658)
15. Brochu-Gaudreau K., Rehfeldt C., Blouin R., Bordignon V., Murphy B. D., Palin M. F. Adiponectin action from head to toe. Endocrine: 2010; 37 11 32
16. Lee Y. H., Magkos F., Mantzoros C. S., Kang E. S. Effects of leptin and adiponectin on pancreatic β-cell function. Metabolism: 2011; 60 1664 1672
17. Zhang Y., Zhou P., Kimondo J. W. Adiponectin and osteocalcin: relation to insulin sensitivity. Biochem Cell Biol: 2012; 90 613 620
18. Luo N., Liu J., Chung B. H., Yang Q., Klein R. L., Garvey W. T., Fu Y. Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis. Diabetes: 2010; 59 791 799
19. Yamauchi T., Kamon J., Waki H., Imai Y., Shimozawa N., Hioki K., Uchida S., Ito Y., Takakuwa K., Matsui J., Takata M., Eto K., Terauchi Y., Komeda K., Tsunoda M., Murakami K., Ohnishi Y., Naitoh T., Yamamura K., Ueyama Y., Froguel P., Kimura S., Nagai R., Kadowaki T. Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis. J Biol Chem: 2003; 278 2461 2468 (Pubitemid 36801322)
20. Shklyaev S., Aslanidi G., Tennant M., Prima V., Kohlbrenner E., Kroutov V., Campbell-Thompson M., Crawford J., Shek E. W., Scarpace P. J., Zolotukhin S. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc Natl Acad Sci USA: 2003; 100 14217 14222 (Pubitemid 37499217)
21. Sulpice T., Prunet-Marcassus B., Molveaux C., Cani P. D., Vitte P. A., Graber P., Dreano M., Burcelin R. An adiponectin-like molecule with antidiabetic properties. Endocrinology: 2009; 150 4493 4501
22. Johnson J. D., Luciani D. S. Mechanisms of pancreatic beta-cell apoptosis in diabetes and its therapies. Adv Exp Med Biol: 2010; 654 447 462