Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca2+ signaling in Huntington's disease

Acta Neuropathologica

Volumn 125, Issue 5, 2013, Pages 727-739

  Lee, Junghee ^a,b   Hwang, Yu Jin ^c   Shin, Jong Yeon ^d,e   Lee, Won Chul ^c,d   Wie, Jinhong ^c   Kim, Ki Yoon ^c   Lee, Min Young ^f   Hwang, Daehee ^f   Ratan, Rajiv R ^g   Pae, Ae Nim ^h   Kowall, Neil W ^a,b   So, Insuk ^c   Kim, Jong Il ^d,e   Ryu, Hoon ^a,b,c  

^a Division of SCI Research   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Seoul National University   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e Psoma Therapeutics Inc   (South Korea)

^f Pohang University of Science and Technology (POSTECH)   (South Korea)

^g BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^h Korea Institute of Science and Technology   (South Korea)

Author keywords

Cholinergic receptor M1; Epigenomes; H3K9me3; Heterochromatin; Huntington's disease

Indexed keywords

CALCIUM ION; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR M1; UNCLASSIFIED DRUG; CHRM1 PROTEIN, HUMAN; HISTONE; HTT PROTEIN, HUMAN; MESSENGER RNA; MUSCARINIC RECEPTOR; NERVE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM SIGNALING; CELL MOTILITY; DOWN REGULATION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HETEROCHROMATIN; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA SEQUENCE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; ANIMAL; DISEASE MODEL; GENETIC EPIGENESIS; GENETICS; METABOLISM; NERVE CELL PLASTICITY; PHYSIOLOGY;

ANIMALS; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; FEMALE; HISTONES; HUMANS; HUNTINGTON DISEASE; MICE; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; PROMOTER REGIONS, GENETIC; RECEPTORS, MUSCARINIC; RNA, MESSENGER;

EID: 84886255831     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1103-z     Document Type: Article

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