Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway

Free Radical Biology and Medicine

Volumn 51, Issue 6, 2011, Pages 1164-1174

  Shin Kang, Sonyo ^a   Ramsauer, Victoria P ^a,b   Lightner, Janet ^a   Chakraborty, Kanishka ^a   Stone, William ^c   Campbell, Sharon ^a   Reddy, Shrikanth A G ^d   Krishnan, Koyamangalath ^a  

^a East Tennessee State University   (United States)

^b EAST TENNESSEE STATE UNIVERSITY   (United States)

^c TENNESSEE STATE UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

AKT; ERK; Free radicals; Pancreatic cancer; Tocotrienols; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; DELTA TOCOPHEROL; DELTA TOCOTRIENOL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GAMMA TOCOPHEROL; GAMMA TOCOTRIENOL; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; ONCOGENE PROTEIN V-AKT; PANCREATIC NEOPLASMS; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TOCOTRIENOLS;

AGOUTI PACA;

EID: 80051789323     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.06.008     Document Type: Article

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