Induction of DNA damage and caspase-independent programmed cell death by vitamin e

Nutrition and Cancer

Volumn 64, Issue 1, 2012, Pages 136-152

  Constantinou, C ^a   Neophytou, C M ^b   Vraka, P ^b   Hyatt, J A ^c,d   Papas, K A ^c   Constantinou, A I ^b  

^a Yasoo Health Ltd   (Cyprus)

^b UNIVERSITY OF CYPRUS   (Cyprus)

^c Yasoo Health   (United States)

^d EAST TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOPHERYL POLYETHYLENE GLYCOL ETHER; ALPHA TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; ANTINEOPLASTIC AGENT; CARBOBENZOXY VALYLALANYLASPARTYL(O METHYL)FLUOROMETHYL KETONE; CASPASE 3; CASPASE INHIBITOR; DELTA TOCOTRIENOL; DELTA TOCOTRIENOL SUCCINATE; ETOPOSIDE; GAMMA TOCOTRIENOL; GAMMA TOCOTRIENOL SUCCINATE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PROSTATE CANCER;

APOPTOSIS; CASPASE 3; CASPASES; CELL LINE, TUMOR; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; ETOPOSIDE; HUMANS; ISOMERISM; MALE; POLY(ADP-RIBOSE) POLYMERASES; POLYETHYLENE GLYCOLS; PROSTATIC NEOPLASMS; VITAMIN E;

EID: 84856845784     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2012.630167     Document Type: Article

References (55)

1. Jemal A, Siegele R, Ward E, Murray T, Xu J.et al. Cancer statistics. CA Cancer J Clin 56, 106-130, 2006.
2. Berrino F and Muti P. Mediterranean diet and cancer. Eur J Clin Nutr 43, 49-55, 1989. (Pubitemid 19226989)
3. Khlat M. Cancer in Mediterranean migrants-based on studies in France and Australia. Cancer Causes Control 6, 525-531, 1995.
4. Eichholzer M, Sẗahelin HB, Gey KF, L̈udin E, and Bernasconi F. Prediction of male cancer mortality by plasma levels of interacting vitamins: 17-year follow-up of the prospective Basel study. Int J Cancer 66, 145-150, 1996. (Pubitemid 26248191)
5. Pastori M, Pfander H, and Boscoboinik D. Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. Biochem Biophys Res Commun 250, 582-585, 1998. (Pubitemid 28484769)
6. McIntyre BS, Briski KP, Gapor A, and Sylvester PW: Anti-proliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc Soc Exp Biol Med 224, 292-301, 2000. (Pubitemid 30643508)
7. Min J, Guo J, Zhao F, and Cai D. Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells (HepG2). Wei Sheng Yan 32, 343-345, 2003.
8. Campbell SE, Stone WL, Lee S, Whaley S, Yang H,.et al. Comparative effects of RRR-α and RRR-? -tocopherol on proliferation and apoptosis in human colon cancer cell lines. BMC Cancer 6, 13, 2006.
9. Kumar KS, Raghavan M, Hieber K, Ege C, Mog S,.et al. Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. Life Sci 78, 2099-2104, 2006.
10. Limpens J, Schroder FH, de Ridder CM, Bolder CA,WildhagenMF,.et al. Combined lycopene and vitamin E treatment suppresses the growth of PC- 346C human prostate cancer cells in nude mice. J Nutr 136, 1287-1293, 2006.
11. Constantinou C, Papas A, and Constantinou AI: Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs. Int J Cancer 123, 739-752, 2008. (Pubitemid 352032398)
12. Burton GW and Traber MG: Vitamin E. Antioxidant activity, biokinetics, and biovailability. Annu Rev Nutr 10, 357-382, 1990.
13. Kamal-Eldin A and Appelqvist LA: The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671-701, 1996. (Pubitemid 26240763)
14. Ozer KN and Azzi A. Antioxidant Status, Diet, Nutrition and Health, Papas A (ed.). CRC Press, Boca Raton, FL, 1998, pp. 449-460.
15. Yu W, Simmons-Menchaca M, Gapor A, Sanders BG, and Kline K. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer 33, 26-32, 1999. (Pubitemid 29196119)
16. Sylvester PW and Shah S. Intracellular mechanisms mediating tocotrienolinduced apoptosis in neoplastic mammary epithelial cells. Asia Pac J Clin Nutr 14, 366-373, 2005. (Pubitemid 43219093)
17. Sakai M, Okabe M, Tachibana H, and Yamada K. Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. J Nutr Biochem 17, 672-676, 2006. (Pubitemid 44380370)
18. Srivastava JK and Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun 346, 447-453, 2006. (Pubitemid 43902706)
19. Constantinou C, Hyatt J, Vraka PS, Hadjivassiliou V, Papas KA,.et al. Regulation of caspase-independent cell death by vitamin E natural homologs and synthetic derivatives. Nutr Cancer 61, 864-874, 2009.
20. Wada S. Chemoprevention of tocotrienols: The mechanism of antiproliferative effects. Forum Nutr 61, 204-216, 2009.
21. Sundram K, Khor HT, Ong AS, and Pathmanathan R. Effect of dietary palm oils on mammary carcinogenesis in female rats induced by 7,12- dimethylbenz(a)anthracene. Cancer Res 49, 1447-1451, 1989. (Pubitemid 19088680)
22. He L,MoH, Hadisusilo S, Qureshi AA, and Elson CE: Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 127, 668-674, 1997. (Pubitemid 27200738)
23. Shah S and Sylvester PW: Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signalling in neoplastic mammary epithelial cells. Exp Biol Med (Maywood) 229, 745-755, 2004. (Pubitemid 39166478)
24. Constantinou C, Papas KA, and Constantinou AI: Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy? Curr Cancer Drug Targets 9, 717-728, 2009.
25. Jiang Q, Wong J, and Ames BN: Gamma tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspasedependent and -independent mechanisms.AnnNYAcad Sci 1031, 399-400, 2004. (Pubitemid 40361789)
26. Takahashi K and Loo G: Disruption of mitochondria during tocotrienolinduced apoptosis in MDA-MB-231 human breast cancer cells. Biochem Pharmacol 67, 315-324, 2004. (Pubitemid 38112762)
27. Birringer M, EyTina JH, Salvatore BA, and Neuzil J. Vitamin E analogues as inducers of apoptosis: structure-function relation. Br J Cancer 88, 1948-1955, 2003. (Pubitemid 36829673)
28. Neuzil J, Tomasetti M, Mellick AS, Alleva R, Salvatore BA,.et al. Vitamin E analogues: A new class of inducers of apoptosis with selective anticancer effects. Curr Cancer Drug Targets 4, 355-372, 2004. (Pubitemid 38797247)
29. Prasad KN and Edwards-Prasad J. Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture. Cancer Res 42, 550-554, 1982.
30. Fariss MW, Nicholls-Grzemski FA, Tirmenstein MA, and Zhang JG: Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria. Free Radic Biol Med 31, 530-541, 2001. (Pubitemid 32728440)
31. Yu W, Liao QY, Hantash FM, Sanders BG, and Kline K. Activation of extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells. Cancer Res 61, 6569-6576, 2001. (Pubitemid 32783266)
32. Kumar B, Jha MN, Cole WC, Bedford JS, and Prasad KN: D-alphatocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells. J Am Coll Nutr 21, 339-243, 2002.
33. Lawson KA, Anderson K, Simmons-Menchaca M, Atkinson J, Sun L,.et al. Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis. Mol Cancer Ther 2, 437-444, 2003.
34. Neuzil J. Alpha tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion. Biochem Biophys Res Comm 293, 1309-1313, 2002. (Pubitemid 34681018)
35. Anderson K, Simmons-Menchaca M, Lawson KA, Atkinson J, Sanders BG,.et al. Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E Succinate and vitamin E analogue, α-TEA. Cancer Res 64, 4263-4269, 2004. (Pubitemid 38802432)
36. Shun MC, Yu W, Gapor A, Parsons R, Atkinson J,.et al. Proapoptotic mechanisms of action of a novel vitamin E analog (α-TEA) and a naturally occurring form of vitamin E (d-tocotrienol) inMDA-MB-435 human breast cancer cells. Nutr Cancer 48, 95-105, 2004. (Pubitemid 38823551)
37. Cawley J and Stern M. U.S. Patent 2,680,749 (to Eastman Kodak), 1951.
38. Goh S, Hew N, Ong A, Choo Y, and Brumby S. Tocotrienols from palm oil: Electron spin resonance spectra of tocotrienoxyl radicals. J Am Oil Chem Soc 67, 250-254, 1990. (Pubitemid 20706013)
39. Hyatt J. U.S. Patent 5,869,704 (to Eastman Chem. Co.), 1999.
40. Decker P, Isenberg D, and Muller S. Inhibition of caspase-3-mediated poly(adp-ribose) polymerase (parp) apoptotic cleavage by human parp autoantibodies and effect on cells undergoing apoptosis. J Biol Chem 275, 9043-9046, 2000. (Pubitemid 30180264)
41. Wu XX, Kakehi J, Jin XH, Inui N, and Sugimoto M. Induction of apoptosis in human renal cell carcinoma cells by vitamin E succinate in caspaseindependent manner. Urology 73, 193-199, 2009.
42. Yun SJ, LeeDJ, KimMO, Jung B, Kim SO,. et al.Reduction but not cleavage of poly(ADP-ribose) polymerase during stress-mediated cell death in the rat hippocampus. Neuroreport 14, 935-939, 2003. (Pubitemid 36829767)
43. McGinnis KM, Gnegy ME, Park YH, Mukerjee N, and Wang KK: Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates. Biochem Biophys Res Comm 263, 94-99, 1999. (Pubitemid 29443645)
44. Brunk UT, Neuzil J, and Eaton J. Lysosomal involvement in apoptosis. Redox Rep 6, 91-97, 2001. (Pubitemid 32519816)
45. Neuzil J, Zhao M, Ostermann G, Sticha M, Gellert N,.et al. Alphatocopheryl succinate, an agent with in vivo antitumor activity, induces apoptosis by causing lysosomal instability. Biochem J 362, 709-715, 2002. (Pubitemid 34242323)
46. Johnson DE:Non-caspase proteases in apoptosis. Leukemia 14, 1695-1703, 2000.
47. Sun W, Wang Q, Chen B, Liu J, Liu H,.et al. Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. Br J Nutr 99, 1247-1254, 2008.
48. Yip KW and Reed JC: Bcl-2 family proteins and cancer. Oncogene 27, 6398-6406, 2007.
49. Polster BM, Basãnez G, Etxebarria A, Hardwick JM, and Nicholls DG: Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. J Biol Chem 280, 6447-6454, 2005. (Pubitemid 40341192)
50. MoubarakRS,YusteVJ, ArtusC,Bouharrour A, Greer PA,.et al. Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol 27, 4844-4862, 2007. (Pubitemid 47016136)
51. McEleny K, Watson RW, Coffey RN, O'Neill AJ, and Fitzpatrick JM: Inhibitors of apoptosis proteins in prostate cancer cell lines. Prostate 51, 133-140, 2002.
52. Yamanaka K, Rocchi P, Miyake H, Fazli L, Vessella B,.et al. A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgenindependent human prostate cancer PC3 cells. Mol Cancer Ther 4, 1689-1697, 2005.
53. Wali V, Bachawal SV, and Sylvester PW: Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. Apoptosis 14, 1366-1377, 2009.
54. Park SK, Sanders BG, and Kline K. Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling. Breast Cancer Res Treat 124, 361-375, 2010.
55. Tiwary R, Yu W, Li J, Park SK, Sanders BG, and Kline K. Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS One 5, 2010, e11865.