-
1
-
-
78149499652
-
A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design
-
Acher FC, Selvam C, Pin JP, Goudet C, and Bertrand HO (2011) A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design. Neuropharmacology 60:102-107.
-
(2011)
Neuropharmacology
, vol.60
, pp. 102-107
-
-
Acher, F.C.1
Selvam, C.2
Pin, J.P.3
Goudet, C.4
Bertrand, H.O.5
-
2
-
-
84890503612
-
The concise guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
-
Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA, and Harmar AJ; CGTP Collaborators (2013) The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol 170: 1459-1581.
-
(2013)
Br J Pharmacol
, vol.170
, pp. 1459-1581
-
-
Alexander, S.P.1
Benson, H.E.2
Faccenda, E.3
Pawson, A.J.4
Sharman, J.L.5
Spedding, M.6
Peters, J.A.7
Harmar, A.J.8
-
3
-
-
0023160180
-
A L-[3H]glutamate binding site on glia: An autoradiographic study on implanted astrocytes
-
Bridges RJ, Kesslak JP, Nieto-Sampedro M, Broderick JT, Yu J, and Cotman CW (1987) A L-[3H]glutamate binding site on glia: an autoradiographic study on implanted astrocytes. Brain Res 415:163-168.
-
(1987)
Brain Res
, vol.415
, pp. 163-168
-
-
Bridges, R.J.1
Kesslak, J.P.2
Nieto-Sampedro, M.3
Broderick, J.T.4
Yu, J.5
Cotman, C.W.6
-
4
-
-
0027765508
-
Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
-
Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, and Hebert SC (1993) Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 366:575-580.
-
(1993)
Nature
, vol.366
, pp. 575-580
-
-
Brown, E.M.1
Gamba, G.2
Riccardi, D.3
Lombardi, M.4
Butters, R.5
Kifor, O.6
Sun, A.7
Hediger, M.A.8
Lytton, J.9
Hebert, S.C.10
-
5
-
-
84865741390
-
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?
-
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, and Bruno V (2012) Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic? Neurochem Int 61:559-565.
-
(2012)
Neurochem Int
, vol.61
, pp. 559-565
-
-
Caraci, F.1
Battaglia, G.2
Sortino, M.A.3
Spampinato, S.4
Molinaro, G.5
Copani, A.6
Nicoletti, F.7
Bruno, V.8
-
6
-
-
68149092677
-
Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions
-
Chaudhry C, Plested AJR, Schuck P, and Mayer ML (2009) Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions. Proc Natl Acad Sci USA 106:12329-12334.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12329-12334
-
-
Chaudhry, C.1
Plested, A.J.R.2
Schuck, P.3
Mayer, M.L.4
-
7
-
-
84904301809
-
International Union of Basic and Clinical Pharmacology. XC. Multisite pharmacology: Recommendations for the nomenclature of receptor allosterism and allosteric ligands
-
Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, and Pin JP et al. (2014) International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacol Rev 66:918-947.
-
(2014)
Pharmacol Rev
, vol.66
, pp. 918-947
-
-
Christopoulos, A.1
Changeux, J.P.2
Catterall, W.A.3
Fabbro, D.4
Burris, T.P.5
Cidlowski, J.A.6
Olsen, R.W.7
Peters, J.A.8
Neubig, R.R.9
Pin, J.P.10
-
8
-
-
0030995878
-
Pharmacology and functions of metabotropic glutamate receptors
-
Conn PJ and Pin JP (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37:205-237.
-
(1997)
Annu Rev Pharmacol Toxicol
, vol.37
, pp. 205-237
-
-
Conn, P.J.1
Pin, J.P.2
-
9
-
-
34547686245
-
The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection
-
Corti C, Battaglia G, Molinaro G, Riozzi B, Pittaluga A, Corsi M, Mugnaini M, Nicoletti F, and Bruno V (2007) The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J Neurosci 27:8297-8308.
-
(2007)
J Neurosci
, vol.27
, pp. 8297-8308
-
-
Corti, C.1
Battaglia, G.2
Molinaro, G.3
Riozzi, B.4
Pittaluga, A.5
Corsi, M.6
Mugnaini, M.7
Nicoletti, F.8
Bruno, V.9
-
10
-
-
84901228254
-
A real-time method for measuring cAMP production modulated by Gαi/o-coupled metabotropic glutamate receptors
-
DiRaddo JO, Miller EJ, Hathaway HA, Grajkowska E, Wroblewska B, Wolfe BB, Liotta DC, and Wroblewski JT (2014) A real-time method for measuring cAMP production modulated by Gαi/o-coupled metabotropic glutamate receptors. J Pharmacol Exp Ther 349:373-382.
-
(2014)
J Pharmacol Exp Ther
, vol.349
, pp. 373-382
-
-
DiRaddo, J.O.1
Miller, E.J.2
Hathaway, H.A.3
Grajkowska, E.4
Wroblewska, B.5
Wolfe, B.B.6
Liotta, D.C.7
Wroblewski, J.T.8
-
11
-
-
45749139623
-
Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039)
-
Fell MJ, Svensson KA, Johnson BG, and Schoepp DD (2008) Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039). J Pharmacol Exp Ther 326:209-217.
-
(2008)
J Pharmacol Exp Ther
, vol.326
, pp. 209-217
-
-
Fell, M.J.1
Svensson, K.A.2
Johnson, B.G.3
Schoepp, D.D.4
-
12
-
-
84893658110
-
Local impermeant anions establish the neuronal chloride concentration
-
Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, and Staley KJ (2014) Local impermeant anions establish the neuronal chloride concentration. Science 343:670-675.
-
(2014)
Science
, vol.343
, pp. 670-675
-
-
Glykys, J.1
Dzhala, V.2
Egawa, K.3
Balena, T.4
Saponjian, Y.5
Kuchibhotla, K.V.6
Bacskai, B.J.7
Kahle, K.T.8
Zeuthen, T.9
Staley, K.J.10
-
13
-
-
84857594561
-
A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential
-
Goudet C, Vilar B, Courtiol T, Deltheil T, Bessiron T, Brabet I, Oueslati N, Rigault D, Bertrand HO, and McLean H et al. (2012) A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J 26:1682-1693.
-
(2012)
FASEB J
, vol.26
, pp. 1682-1693
-
-
Goudet, C.1
Vilar, B.2
Courtiol, T.3
Deltheil, T.4
Bessiron, T.5
Brabet, I.6
Oueslati, N.7
Rigault, D.8
Bertrand, H.O.9
McLean, H.10
-
14
-
-
84892634537
-
Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1a
-
Jiang JY, Nagaraju M, Meyer RC, Zhang L, Hamelberg D, Hall RA, Brown EM, Conn PJ, and Yang JJ (2014) Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1a. J Biol Chem 289: 1649-1661.
-
(2014)
J Biol Chem
, vol.289
, pp. 1649-1661
-
-
Jiang, J.Y.1
Nagaraju, M.2
Meyer, R.C.3
Zhang, L.4
Hamelberg, D.5
Hall, R.A.6
Brown, E.M.7
Conn, P.J.8
Yang, J.J.9
-
16
-
-
33646411801
-
Ion dependence of ligand binding to metabotropic glutamate receptors
-
Kuang D and Hampson DR (2006) Ion dependence of ligand binding to metabotropic glutamate receptors. Biochem Biophys Res Commun 345:1-6.
-
(2006)
Biochem Biophys Res Commun
, vol.345
, pp. 1-6
-
-
Kuang, D.1
Hampson, D.R.2
-
17
-
-
0032512921
-
Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors
-
Kubo Y, Miyashita T, and Murata Y (1998) Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors. Science 279:1722-1725.
-
(1998)
Science
, vol.279
, pp. 1722-1725
-
-
Kubo, Y.1
Miyashita, T.2
Murata, Y.3
-
18
-
-
0000243829
-
PROCHECK: A program to check the stereochemical quality of protein structures
-
Laskowski RA, MacArthur MW, Moss DS, and Thornton JM (1993) PROCHECK: A program to check the stereochemical quality of protein structures. J Appl Cryst 26:283-291.
-
(1993)
J Appl Cryst
, vol.26
, pp. 283-291
-
-
Laskowski, R.A.1
MacArthur, M.W.2
Moss, D.S.3
Thornton, J.M.4
-
19
-
-
67749144068
-
Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist 3H-HYDIA
-
Lundström L, Kuhn B, Beck J, Borroni E, Wettstein JG, Woltering TJ, and Gatti S (2009) Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist 3H-HYDIA. ChemMedChem 4:1086-1094.
-
(2009)
ChemMedChem
, vol.4
, pp. 1086-1094
-
-
Lundström, L.1
Kuhn, B.2
Beck, J.3
Borroni, E.4
Wettstein, J.G.5
Woltering, T.J.6
Gatti, S.7
-
20
-
-
0030990124
-
Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor anatagonists
-
Ma D, Tian H, Sun H, Kozikowshi AP, Pshenichkin S, and Wroblewski JT (1997) Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor anatagonists. Bioorg Med Chem Lett 7: 1195-1198.
-
(1997)
Bioorg Med Chem Lett
, vol.7
, pp. 1195-1198
-
-
Ma, D.1
Tian, H.2
Sun, H.3
Kozikowshi, A.P.4
Pshenichkin, S.5
Wroblewski, J.T.6
-
21
-
-
0034759133
-
Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor
-
Malherbe P, Knoflach F, Broger C, Ohresser S, Kratzeisen C, Adam G, Stadler H, Kemp JA, and Mutel V (2001) Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor. Mol Pharmacol 60:944-954.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 944-954
-
-
Malherbe, P.1
Knoflach, F.2
Broger, C.3
Ohresser, S.4
Kratzeisen, C.5
Adam, G.6
Stadler, H.7
Kemp, J.A.8
Mutel, V.9
-
22
-
-
0019956825
-
Chloride ions enhance L-glutamate binding to rat brain synaptic membranes
-
Mena EE, Fagg GE, and Cotman CW (1982) Chloride ions enhance L-glutamate binding to rat brain synaptic membranes. Brain Res 243:378-381.
-
(1982)
Brain Res
, vol.243
, pp. 378-381
-
-
Mena, E.E.1
Fagg, G.E.2
Cotman, C.W.3
-
23
-
-
79956211294
-
Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase
-
Misono KS, Philo JS, Arakawa T, Ogata CM, Qiu Y, Ogawa H, and Young HS (2011) Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase. FEBS J 278:1818-1829.
-
(2011)
FEBS J
, vol.278
, pp. 1818-1829
-
-
Misono, K.S.1
Philo, J.S.2
Arakawa, T.3
Ogata, C.M.4
Qiu, Y.5
Ogawa, H.6
Young, H.S.7
-
24
-
-
84879052394
-
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of new potent and selective metabotropic glutamate 2/3 receptor agonists
-
Monn JA, Valli MJ, Massey SM, Hao J, Reinhard MR, Bures MG, Heinz BA, Wang X, Carter JH, and Getman BG et al. (2013) Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists. J Med Chem 56:4442-4455.
-
(2013)
J Med Chem
, vol.56
, pp. 4442-4455
-
-
Monn, J.A.1
Valli, M.J.2
Massey, S.M.3
Hao, J.4
Reinhard, M.R.5
Bures, M.G.6
Heinz, B.A.7
Wang, X.8
Carter, J.H.9
Getman, B.G.10
-
25
-
-
34247210665
-
Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
-
Muto T, Tsuchiya D, Morikawa K, and Jingami H (2007) Structures of the extracellular regions of the group II/III metabotropic glutamate receptors. Proc Natl Acad Sci USA 104:3759-3764.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 3759-3764
-
-
Muto, T.1
Tsuchiya, D.2
Morikawa, K.3
Jingami, H.4
-
26
-
-
41149111966
-
A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors
-
Niswender CM, Johnson KA, Luo Q, Ayala JE, Kim C, Conn PJ, and Weaver CD (2008) A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Mol Pharmacol 73:1213-1224.
-
(2008)
Mol Pharmacol
, vol.73
, pp. 1213-1224
-
-
Niswender, C.M.1
Johnson, K.A.2
Luo, Q.3
Ayala, J.E.4
Kim, C.5
Conn, P.J.6
Weaver, C.D.7
-
27
-
-
77249131336
-
Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: Possible allosteric regulation and a conserved structural motif for the chloridebinding site
-
Ogawa H, Qiu Y, Philo JS, Arakawa T, Ogata CM, and Misono KS (2010) Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: possible allosteric regulation and a conserved structural motif for the chloridebinding site. Protein Sci 19:544-557.
-
(2010)
Protein Sci
, vol.19
, pp. 544-557
-
-
Ogawa, H.1
Qiu, Y.2
Philo, J.S.3
Arakawa, T.4
Ogata, C.M.5
Misono, K.S.6
-
28
-
-
0032004205
-
A modulatory effect of extracellular Ca2+ on type 1α metabotropic glutamate receptor-mediated signalling
-
Saunders R, Nahorski SR, and Challiss RAJ (1998) A modulatory effect of extracellular Ca2+ on type 1α metabotropic glutamate receptor-mediated signalling. Neuropharmacology 37:273-276.
-
(1998)
Neuropharmacology
, vol.37
, pp. 273-276
-
-
Saunders, R.1
Nahorski, S.R.2
Challiss, R.A.J.3
-
29
-
-
0032834028
-
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
-
Schoepp DD, Jane DE, and Monn JA (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38:1431-1476.
-
(1999)
Neuropharmacology
, vol.38
, pp. 1431-1476
-
-
Schoepp, D.D.1
Jane, D.E.2
Monn, J.A.3
-
34
-
-
0034086461
-
Characterization of [3H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors
-
Schweitzer C., Kratzeisen C., Adam G., Lundstrom K., Malherbe P., Ohresser S., Stadler H, Wichmann J, Woltering T, and Mutel V (2000) Characterization of [3H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors. Neuropharmacology 39:1700-1706.
-
(2000)
Neuropharmacology
, vol.39
, pp. 1700-1706
-
-
Schweitzer, C.1
Kratzeisen, C.2
Adam, G.3
Lundstrom, K.4
Malherbe, P.5
Ohresser, S.6
Stadler, H.7
Wichmann, J.8
Woltering, T.9
Mutel, V.10
-
35
-
-
34548848868
-
In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists
-
Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, and Ohta H (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther 323:147-156.
-
(2007)
J Pharmacol Exp Ther
, vol.323
, pp. 147-156
-
-
Suzuki, G.1
Tsukamoto, N.2
Fushiki, H.3
Kawagishi, A.4
Nakamura, M.5
Kurihara, H.6
Mitsuya, M.7
Ohkubo, M.8
Ohta, H.9
-
36
-
-
0036724311
-
Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease
-
Taylor DL, Diemel LT, Cuzner ML, and Pocock JM (2002) Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease. J Neurochem 82:1179-1191.
-
(2002)
J Neurochem
, vol.82
, pp. 1179-1191
-
-
Taylor, D.L.1
Diemel, L.T.2
Cuzner, M.L.3
Pocock, J.M.4
-
37
-
-
15244350494
-
Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor α-induced neurotoxicity in concert with microglial-derived Fas ligand
-
Taylor DL, Jones F, Kubota ESFCS, and Pocock JM (2005) Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor α-induced neurotoxicity in concert with microglial-derived Fas ligand. J Neurosci 25:2952-2964.
-
(2005)
J Neurosci
, vol.25
, pp. 2952-2964
-
-
Taylor, D.L.1
Jones, F.2
Kubota, E.S.F.C.S.3
Pocock, J.M.4
-
38
-
-
77952363301
-
Glutamate receptor ion channels: Structure, regulation, and function
-
Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, and Dingledine R (2010) Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev 62:405-496.
-
(2010)
Pharmacol Rev
, vol.62
, pp. 405-496
-
-
Traynelis, S.F.1
Wollmuth, L.P.2
McBain, C.J.3
Menniti, F.S.4
Vance, K.M.5
Ogden, K.K.6
Hansen, K.B.7
Yuan, H.8
Myers, S.J.9
Dingledine, R.10
-
39
-
-
19444378697
-
Sensitization of adenylate cyclase by Gαi/o-coupled receptors
-
Watts VJ and Neve KA (2005) Sensitization of adenylate cyclase by Gαi/o-coupled receptors. Pharmacol Ther 106:405-421.
-
(2005)
Pharmacol Ther
, vol.106
, pp. 405-421
-
-
Watts, V.J.1
Neve, K.A.2
-
40
-
-
0032190403
-
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes
-
Wroblewska B, Santi MR, and Neale JH (1998) N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes. Glia 24:172-179.
-
(1998)
Glia
, vol.24
, pp. 172-179
-
-
Wroblewska, B.1
Santi, M.R.2
Neale, J.H.3
-
41
-
-
0042230756
-
Molecular modeling and mutagenesis of the ligand-binding pocket of the mGlu3 subtype of metabotropic glutamate receptor
-
Yao Y, Pattabiraman N, Michne WF, Huang XP, and Hampson DR (2003) Molecular modeling and mutagenesis of the ligand-binding pocket of the mGlu3 subtype of metabotropic glutamate receptor. J Neurochem 86:947-957.
-
(2003)
J Neurochem
, vol.86
, pp. 947-957
-
-
Yao, Y.1
Pattabiraman, N.2
Michne, W.F.3
Huang, X.P.4
Hampson, D.R.5
|