Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 30, 2009, Pages 12329-12334

  Chaudhry, Charu ^a   Plested, Andrew J R ^a,c   Schuck, Peter ^b   Mayer, Mark L ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

Allosteric modulation; Analytical ultracentrifugation; Desensitization; Ion channels; Thermodynamics

Indexed keywords

CALCIUM ION; CHLORIDE ION; DIMER; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 6; GLUTAMATE RECEPTOR DELTA2; ION CHANNEL; KAINIC ACID RECEPTOR; MUTANT PROTEIN; SODIUM ION; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DIMERIZATION; ENERGY TRANSFER; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MECHANICS; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; ULTRACENTRIFUGATION; WILD TYPE;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; BINDING SITES; CALCIUM; CELL LINE; CHLORIDES; ENERGY TRANSFER; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, KAINIC ACID; SODIUM; ULTRACENTRIFUGATION;

EID: 68149092677     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904175106     Document Type: Article

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