miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality

Biotechnology and Bioengineering

Volumn 112, Issue 10, 2015, Pages 2142-2153

  Fischer, Simon ^a,b   Paul, Albert Jesuran ^a   Wagner, Andreas ^a,b   Mathias, Sven ^a,b   Geiss, Melanie ^a,b   Schandock, Franziska ^a,b   Domnowski, Martin ^a,b   Zimmermann, Jörg ^a,b   Handrick, René ^a   Hesse, Friedemann ^a   Otte, Kerstin ^a  

^a BIBERACH UNIVERSITY OF APPLIED SCIENCES   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Cell engineering; CHO; MicroRNA; Monoclonal antibody; Product quality; VPA

Indexed keywords

ANTIBODIES; CELL CULTURE; CELLS; CYTOLOGY; GENE EXPRESSION; MAMMALS; MONOCLONAL ANTIBODIES; PRODUCTIVITY; QUALITY CONTROL; RECOMBINANT PROTEINS; RNA;

ANTIBODY AGGREGATION; CHINESE HAMSTER OVARY CELLS; CHO; HISTONE DEACETYLASES; MICRORNAS; QUALITY ATTRIBUTES; RECOMBINANT PROTEIN EXPRESSION; VPA;

CELL ENGINEERING;

HISTONE DEACETYLASE 5; HISTONE DEACETYLASE INHIBITOR; MICRORNA; MICRORNA 2861; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTIBODY;

ANIMAL CELL; ARTICLE; CELL ENGINEERING; CHO CELL LINE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; CRICETULUS; GENE EXPRESSION REGULATION; GENETICS; METABOLIC ENGINEERING; METABOLISM;

CRICETULUS GRISEUS; EUKARYOTA; MAMMALIA;

ANIMALS; ANTIBODIES; CHO CELLS; CRICETULUS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; METABOLIC ENGINEERING; MICRORNAS; RECOMBINANT PROTEINS;

EID: 84939825568     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25626     Document Type: Article

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