Direct analysis of mAb aggregates in mammalian cell culture supernatant

BMC Biotechnology

Volumn 14, Issue 1, 2014, Pages 1-11

  Paul, Albert J ^a   Schwab, Karen ^a   Hesse, Friedemann ^a  

^a BIBERACH UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

CHO cells; Mammalian cell culture; Monoclonal antibodies; Protein aggregation

Indexed keywords

AFFINITY CHROMATOGRAPHY; ANIMAL CELL CULTURE; CELLS; CYTOLOGY; DIMERS; MAMMALS; MONOCLONAL ANTIBODIES; PURIFICATION; SILICA; SIZE EXCLUSION CHROMATOGRAPHY;

AGGREGATE STANDARDS; CHINESE HAMSTER OVARY CELLS; CHO CELL; CULTURE SUPERNATANT; DOWNSTREAM-PROCESSING; MAMMALIAN CELL CULTURE; MONOCLONAL ANTIBODIES (MAB); PROTEIN AGGREGATION;

AGGREGATES;

DIMER; MONOCLONAL ANTIBODY; OLIGOMER; SILICON DIOXIDE; CULTURE MEDIUM; PROTEIN AGGREGATE;

AFFINITY CHROMATOGRAPHY; ANALYTIC METHOD; ANIMAL CELL; ANTIBODY AGGREGATE ANALYSIS; ANTIBODY PRODUCTION; ARTICLE; CELL CULTURE; CHO CELL LINE; CHO DG44 CELL LINE; CONTROLLED STUDY; FEASIBILITY STUDY; MAMMAL CELL; MONOCLONAL ANTIBODY AGGREGATION; NONHUMAN; PROTEIN AGGREGATION; PURIFICATION; QUANTITATIVE ANALYSIS; SIZE EXCLUSION CHROMATOGRAPHY; SUPERNATANT; ANIMAL; CHEMISTRY; CRICETULUS; CULTURE MEDIUM; CULTURE TECHNIQUE; HAMSTER; HUMAN;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; HUMANS; PROTEIN AGGREGATES;

EID: 84928720961     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/s12896-014-0099-3     Document Type: Article

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