Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles

Nanoscale

Volumn 7, Issue 34, 2015, Pages 14191-14216

  Baek, Seonmi ^a   Singh, Rajendra K ^b,c   Khanal, Dipesh ^a   Patel, Kapil D ^b,c   Lee, Eun Jung ^b,c   Leong, Kam W ^b,e   Chrzanowski, Wojciech ^a,b   Kim, Hae Won ^b,c,d  

^a UNIVERSITY OF SYDNEY   (Australia)

^b Dankook University   (South Korea)

^c BK21 Plus NBM Global Research Center for Regenerative Medicine   (South Korea)

^d Dankook University   (South Korea)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; CONTROLLED DRUG DELIVERY; DISEASES; DRUG INTERACTIONS; MEDICAL NANOTECHNOLOGY; NANOMAGNETICS; NANOPARTICLES; NANOSTRUCTURED MATERIALS; REDOX REACTIONS; SILICA; SILICA NANOPARTICLES; THERANOSTICS;

ANTI-CANCER THERAPIES; FUNCTIONALIZATIONS; MESOPOROUS NANOPARTICLE; MESOPOROUS SILICA NANOPARTICLES; MULTIFUNCTIONAL NANOCARRIER; NANO-SCALE MATERIALS; SMART DRUG DELIVERY SYSTEMS; STRUCTURAL DIVERSITY;

TARGETED DRUG DELIVERY;

ANTINEOPLASTIC AGENT; DRUG CARRIER; NANOPARTICLE; SILICON DIOXIDE;

ANIMAL; CHEMISTRY; DRUG RELEASE; HUMAN; METABOLISM; NEOPLASMS; OXIDATION REDUCTION REACTION; POROSITY;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; DRUG LIBERATION; HUMANS; NANOPARTICLES; NEOPLASMS; OXIDATION-REDUCTION; POROSITY; SILICON DIOXIDE;

EID: 84939824693     PISSN: 20403364     EISSN: 20403372     Source Type: Journal    
DOI: 10.1039/c5nr02730f     Document Type: Review

References (159)

1. Y. Wang S. Song J. Liu D. Liu H. Zhang ZnO-Functionalized Upconverting Nanotheranostic Agent: Multi-Modality Imaging-Guided Chemotherapy with On-Demand Drug Release Triggered by pH Angew. Chem., Int. Ed. 2015 54 536 540
2. X. Ma H. Yu Global Burden of Cancer Yale J. Biol. Med. 2007 79 85 94
3. B. E. Hillner T. J. Smith Efficacy Dose Not Necessarily Translate to Cost Effectiveness: A Case Study in the Challenges Associated With 21st-Century Cancer Pricing J. Clin. Oncol. 2009 27 2111 2113
4. M. Dean T. Fojo S. Bates Tumour stem cells and drug resistance Nat. Rev. Cancer 2005 5 275 284
5. G.F Paciotti D.GI. Kingston L. Tamarkin Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor-targeted drug delivery vectors Drug Dev. Res. 2006 67 47 54
6. B. G. Trewyn S. Giri I. I. Slowing V. S. Y. Lin Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems Chem. Commun. 2007 3236 3245
7. N. Nasongkla E. Bey J. Ren H. Ai C. Khemtong J. S. Guthi et al., Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems Nano Lett. 2006 6 2427 2430
8. K.S Soppimath D.CW. Tan Y.Y Yang pH-Triggered Thermally Responsive Polymer Core-Shell Nanoparticles for Drug Delivery Adv. Mater. 2005 17 318 323
9. S. Dromi V. Frenkel A. Luk B. Traughber M. Angstadt M. Bur et al., Pulsed-High Intensity Focused Ultrasound and Low Temperature-Sensitive Liposomes for Enhanced Targeted Drug Delivery and Antitumor Effect Clin. Cancer Res. 2007 13 2722 2727
10. H. Yang W. J. Kao Synthesis and characterization of nanoscale dendritic RGD clusters for potential applications in tissue engineering and drug delivery Int. J. Nanomed. 2007 2 89 99
11. V.-R. Maria R.-H. Eduardo G. Blanca B. Alejandro Design of Smart Nanomaterials for Drug and Gene Delivery Acc. Chem. Res. 2011 1 6 29
12. M. W. Ambrogio C. R. Thomas Y.-L. Zhao J. I. Zink J. F. Stoddart Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine Acc. Chem. Res. 2011 44 903 913
13. F.-F. An W. Cao X.-J. Liang Nanostructural Systems Developed with Positive Charge Generation to Drug Delivery Adv. Healthcare Mater. 2014 3 1162 1181
14. K. N. Yang C. Q. Zhang W. Wang P. C. Wang J. P. Zhou X. J. Liang pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment Cancer Biol. Med. 2014 11 34 43
15. M. Vallet-Regí F. Balas D. Arcos Mesoporous Materials for Drug Delivery Angew. Chem., Int. Ed. 2007 46 7548 7558
16. M. Manzano M. Colilla M. Vallet-Regí Drug delivery from ordered mesoporous matrices Expert Opin. Drug Delivery 2009 6 1383 1400
17. P. Yang S. Gai J. Lin Functionalized mesoporous silica materials for controlled drug delivery Chem. Soc. Rev. 2012 41 3679 3698
18. M. Manzano M. Vallet-Regi New developments in ordered mesoporous materials for drug delivery J. Mater. Chem. 2010 20 5593 5604
19. W. X. Mai H. Meng Mesoporous silica nanoparticles: A multifunctional nano therapeutic system Integr. Biol. 2013 5 19 28
20. G. Soni K. S. Yadav Nanogels as potential nanomedicine carrier for treatment of cancer: A mini review of the state of the art Saudi Pharm. J. 2014 10.1016/j.jsps.2014.04.001
21. M. M. Yallapu M. Jaggi S. C. Chauhan Design and engineering of nanogels for cancer treatment Drug Discovery Today 2011 16 457 463
22. A. M. Jhaveri V. P. Torchilin Multifunctional polymeric micelles for delivery of drugs and siRNA Front. Pharmacol. 2014 5 77
23. S. Maya B. Sarmento A. Nair N. S. Rejinold S. V. Nair R. Jayakumar Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review Curr. Pharm. Des. 2013 19 15
24. G. Salas R. Costo M. d. P. Morales Synthesis of Inorganic Nanoparticles Front. Nanosci. 2012 4 35 65
25. A. J. Wagstaff S. D. Brown M. R. Holden G. E. Craig J. A. Plumb R. E. Brown et al., Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields Inorg. Chim. Acta 2012 393 328 333
26. D. Upadhyay S. Scalia R. Vogel N. Wheate R. Salama P. Young et al., Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery Pharm. Res. 2012 29 2456 2467
27. K. J. Tapan M. A. Morales S. K. Sahoo S. L. Leslie-Pelecky V. Labhasetwar Iron Oxide Nanoparticles for Sustained Delivery of ANricancer Agents Mol. Pharm. 2005 2 194 205
28. S. Perni C. Piccirillo J. Pratten P. Prokopovich W. Chrzanowski I. P. Parkin et al., The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles Biomaterials 2009 30 89 93
29. C. W. Dunnill Z. A. Aiken A. Kafizas J. Pratten M. Wilson D. J. Morgan I. P. Parkin White Light Induced Photocatalytic Activity of Sulfur-Doped TiO2 Thin Films and their Potential for Antibacterial Application J. Mater. Chem. 2009 19 8747 8754
30. D. Douroumis I. Onyesom M. Maniruzzaman J. Mitchell Mesoporous silica nanoparticles in nanotechnology Crit. Rev. Biotechnol. 2013 33 3 229 245
31. Y. Zhao J. L. Vivero-Escoto I. I. Slowing B. G. Trewyn V. S.-Y. Lin Capped mesoporous silica nanoparticles as stimuli-responsive controlled release systems for intracellular drug/gene delivery Expert Opin. Drug Delivery 2010 7 1013 1029
32. J. M. Rosenholm C. Sahlgren M. Linden Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles-opportunities & challenges Nanoscale 2010 2 1870 1883
33. J. L. Vivero-Escoto I. I. Slowing B. G. Trewyn V. S. Lin Mesoporous silica nanoparticles for intracellular controlled drug delivery Small 2010 6 1952 1967
34. J. Lu M. Liong J. I. Zink F. Tamanoi Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs Small 2007 3 1341 1346
35. M. Colilla B. González M. Vallet-Regí Mesoporous silica nanoparticles for the design of smart delivery nanodevices Biomater. Sci. 2013 1 114
36. J. Lu Z. Li J. I. Zink F. Tamanoi In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification Nanomedicine 2012 8 212 220
37. Y. Gao Y. Chen X. Ji X. He Q. Yin Z. Zhang et al., Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Am. Chem. Soc. 2011 5 9788 9798
38. D. Pérez-Quintanilla S. Gómez-Ruiz Ž. Žižak I. Sierra S. Prashar I. del Hierro et al., A New Generation of Anticancer Drugs: Mesoporous Materials Modified with Titanocene Complexes Chem.-Eur. J. 2009 15 5588 5597
39. B. Ahn J. Park K. Singha H. Park W. J. Kim Mesoporous silica nanoparticle-based cisplatin prodrug delivery and anticancer effect under reductive cellular environment J. Mater. Chem. B 2013 1 2829 2836
40. J. Lu M. Liong J. I. Zink F. Tamanoi Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs Small 2007 3 1341 1346
41. C. Chen J. Geng F. Pu X. Yang J. Ren X. Qu Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli-Responsive Vehicles for Intracellular Drug Delivery Angew. Chem., Int. Ed. 2011 50 882 886
42. B. Zheng S. Xu L. Lin Z. Wang Z. Feng Z. Zheng Plasmon enhanced near-infrared quantum cutting of KYF 4: Tb 3+, Yb 3+ doped with Ag nanoparticles Opt. Lett. 2015 40 2630 2633
43. G. Férey C. Mellot-Draznieks C. Serre F. Millange J. Dutour S. Surblé et al., A Chromium Terephthalate-Based Solid with Unusually Large Pore Volumes and Surface Area Science 2005 309 2040 2042
44. J. Fan C. Yu F. Gao J. Lei B. Tian L. Wang et al., Cubic Mesoporous Silica with Large Controllable Entrance Sizes and Advanced Adsorption Properties Angew. Chem., Int. Ed. 2003 42 3146 3150
45. T. Azaïs C. Tourné-Péteilh F. Aussenac N. Baccile C. Coelho J.-M. Devoisselle et al., Solid-State NMR Study of Ibuprofen Confined in MCM-41 Material Chem. Mater. 2006 18 6382 6390
46. R. E. Yanes F. Tamanoi Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery Ther. Delivery 2012 3 389 404
47. Y. Chen H. Chen D. Zeng Y. Tian F. Chen J. Feng et al., Core/Shell Structured Hollow Mesoporous Nanocapsules: A Potential Platform for Simultaneous Cell Imaging and Anticancer Drug Delivery ACS Nano 2010 4 6001 6013
48. J. E. Lee N. Lee T. Kim J. Kim T. Hyeon Multifunctional Mesoporous Silica Nanocomposite Nanoparticles for Teranostic Applications Acc. Chem. Res. 2011 44 893 902
49. J. Kim H. Moon T. Kim S. Yang J. Park D. Naskar et al., Developing animal models for alveolar bone scaffolds and tissue engineering J. Tissue Eng. Regener. Med. 2014 495 496
50. Q. Yang S. Wang P. Fan L. Wang Y. Di K. Lin et al., pH-Responsive Carrier System Based on Carboxylic Acid Modified Mesoporous Silica and Polyelectrolyte for Drug Delivery Chem. Mater. 2005 17 5999 6003
51. M. Xie H. Shi K. Ma H. Shen B. Li S. Shen et al., Hybrid nanoparticles for drug delivery and bioimaging: mesoporous silica nanoparticles functionalized with carboxyl groups and a near-infrared fluorescent dye J. Colloid Interface Sci. 2013 395 306 314
52. J. Fan G. Fang X. Wang F. Zeng Y. Xiang S. Wu Targeted anticancer prodrug with mesoporous silica nanoparticles as vehicles Nanotechnology 2011 22 455102
53. C.-H. Lee S.-H. Cheng I. P. Huang J. S. Souris C.-S. Yang C.-Y. Mou et al., Intracellular pH-Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics Angew. Chem., Int. Ed. 2010 49 8214 8219
54. C.-H. Lin S.-H. Cheng W.-N. Liao P.-R. Wei P.-J. Sung C.-F. Weng et al., Mesoporous silica nanoparticles for the improved anticancer efficacy of cis-platin Int. J. Pharm. 2012 429 138 147
55. R. Liu Y. Zhang X. Zhao A. Agarwal L. J. Mueller P. Feng pH-Responsive Nanogated Ensemble Based on Gold-Capped Mesoporous Silica through an Acid-Labile Acetal Linker J. Am. Chem. Soc. 2010 132 1500 1501
56. E. Aznar C. Coll M. D. Marcos R. Martínez-Máñez F. Sancenón J. Soto et al., Borate-Driven Gatelike Scaffolding Using Mesoporous Materials Functionalised with Saccharides Chem.-Eur. J. 2009 15 6877 6888
57. Q. Gan X. Lu Y. Yuan J. Qian H. Zhou X. Lu et al., A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica Biomaterials 2011 32 1932 1942
58. L. Chen J. Di C. Cao Y. Zhao Y. Ma J. Luo et al., A pH-driven DNA nanoswitch for responsive controlled release Chem. Commun. 2011 47 2850 2852
59. C. Park K. Oh S. C. Lee C. Kim Controlled Release of Guest Molecules from Mesoporous Silica Particles Based on a pH-Responsive Polypseudorotaxane Motif Angew. Chem., Int. Ed. 2007 46 1455 1457
60. K. K. Coti M. E. Belowich M. Liong M. W. Ambrogio Y. A. Lau H. A. Khatib et al., Mechanised nanoparticles for drug delivery Nanoscale 2009 1 16 39
61. S. Saha K.CF. Leung T.D Nguyen J.F Stoddart J.I Zink Nanovalves Adv. Funct. Mater. 2007 17 685 693
62. Y.-L. Zhao Z. Li S. Kabehie Y. Y. Botros J. F. Stoddart J. I. Zink pH-Operated Nanopistons on the Surfaces of Mesoporous Silica Nanoparticles J. Am. Chem. Soc. 2010 132 13016 13025
63. H. Meng M. Xue T. Xia Y.-L. Zhao F. Tamanoi J. F. Stoddart et al., Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves J. Am. Chem. Soc. 2010 132 12690 12697
64. F. Muhammad M. Guo W. Qi F. Sun A. Wang Y. Guo et al., pH-Triggered Controlled Drug Release from Mesoporous Silica Nanoparticles via Intracelluar Dissolution of ZnO Nanolids J. Am. Chem. Soc. 2011 133 8778 8781
65. C. Gao H. Zheng L. Xing M. Shu S. Che Designable Coordination Bonding in Mesopores as a pH-Responsive Release System Chem. Mater. 2010 22 5437 5444
66. A. Popat J. Liu G. Q. Lu S. Z. Qiao A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles J. Mater. Chem. 2012 22 11173 11178
67. F. Chen Y. Zhu Chitosan enclosed mesoporous silica nanoparticles as drug nano-carriers: Sensitive response to the narrow pH range Microporous Mesoporous Mater. 2012 150 83 89
68. H. Tang J. Guo Y. Sun B. Chang Q. Ren W. Yang Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery Int. J. Pharm. 2011 421 388 396
69. K. Murakami X. Yu S. Watanabe T. Kato Y. Inoue K. Sugawara Synthesis of thermosensitive polymer/mesoporous silica composite and its temperature dependence of anion exchange property J. Colloid Interface Sci. 2011 354 771 776
70. A. Zintchenko M. Ogris E. Wagner Temperature Dependent Gene Expression Induced by PNIPAM-Based Copolymers: Potential of Hyperthermia in Gene Transfer Bioconjugate Chem. 2006 17 766 772
71. K. Nagase J. Kobayashi A. Kikuchi Y. Akiyama H. Kanazawa T. Okano Interfacial Property Modulation of Thermoresponsive Polymer Brush Surfaces and Their Interaction with Biomolecules Langmuir 2007 23 9409 9415
72. M. Keerl V. Smirnovas R. Winter W. Richtering Copolymer Microgels from Mono- and Disubstituted Acrylamides: Phase Behavior and Hydrogen Bonds Macromolecules 2008 41 6830 6836
73. T. Hoare J. Santamaria G. F. Goya S. Irusta D. Lin S. Lau et al., A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery Nano Lett. 2009 9 3651 3657
74. A. Schlossbauer S. Warncke P.ME. Gramlich J. Kecht A. Manetto T. Carell et al., A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica Angew. Chem., Int. Ed. 2010 49 4734 4737
75. A. Baeza E. Guisasola E. Ruiz-Hernández M. Vallet-Regí Magnetically Triggered Multidrug Release by Hybrid Mesoporous Silica Nanoparticles Chem. Mater. 2012 24 517 524
76. C.-Y. Lai B. G. Trewyn D. M. Jeftinija K. Jeftinija S. Xu S. Jeftinija et al., A Mesoporous Silica Nanosphere-Based Carrier System with Chemically Removable CdS Nanoparticle Caps for Stimuli-Responsive Controlled Release of Neurotransmitters and Drug Molecules J. Am. Chem. Soc. 2003 125 4451 4459
77. S. Giri B.G Trewyn M.P Stellmaker V.SY. Lin Stimuli-Responsive Controlled-Release Delivery System Based on Mesoporous Silica Nanorods Capped with Magnetic Nanoparticles Angew. Chem., Int. Ed. 2005 44 5038 5044
78. F. Torney B.G Trewyn V.SY. Lin K. Wang Mesoporous silica nanoparticles deliver DNA and chemicals into plants Nat. Nanotechnol. 2007 2 295 300
79. P. Nadrah U. Maver A. Jemec T. Tisler M. Bele G. Drazic et al., Hindered Disulfide Bonds to Regulate Release Rate of Model Drug from Mesoporous Silica ACS Appl. Mater. Interfaces 2013 5 9 3908 3915
80. R. Liu X. Zhao T. Wu P. Feng Tunable Redox-Responsive Hybrid Nanogated Ensembles J. Am. Chem. Soc. 2008 130 14418 14419
81. Z. Luo K. Cai Y. Hu L. Zhao P. Liu L. Duan et al., Mesoporous Silica Nanoparticles End-Capped with Collagen: Redox-Responsive Nanoreservoirs for Targeted Drug Delivery Angew. Chem., Int. Ed. 2011 50 640 643
82. E. Climent A. Bernardos R. Martinez-Manez A. Maquieira M. D. Marcos N. Pastor-Navarro et al., Controlled Delivery System Using Antibody-Capped Mesoporous Nanocontainers J. Am. Chem. Soc. 2009 131
83. A. Schlossbauer J. Kecht T. Bein Biotin-Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica Angew. Chem., Int. Ed. 2009 48 3092 3095
84. A. Bernardos E. Aznar M. D. Marcos R. Martínez-Máñez F. Sancenón J. Soto et al., Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose Angew. Chem., Int. Ed. 2009 48 5884 5887
85. A. Agostini L. Mondragón C. Coll E. Aznar M. D. Marcos R. Martinez-Manez et al. ChemistryOpen 2012 1 17 20
86. Y. Zhao B.G Trewyn I.I Slowing V.SY. Lin Mesoporous Silica Nanoparticle-Based Double Drug Delivery System for Glucose-Responsive Controlled Release of Insulin and Cyclic AMP J. Am. Chem. Soc. 2009 131 8398 8400
87. A. D. Ellington J. W. Szostak In vitro selection of RNA molecules that bind specific ligands Nature 1990 346 818 822
88. V. C. Ozalp F. Eyidogan H. A. Oktem Aptamer-Gated Nanoparticles for Smart Drug Delivery Pharmaceuticals 2011 4 1137 1157
89. C.-L. Zhu C.-H. Lu X.-Y. Song H.-H. Yang X.-R. Wang Bioresponsive Controlled Release Using Mesoporous Silica Nanoparticles Capped with Aptamer-Based Molecular Gate J. Am. Chem. Soc. 2011 133 1278 1281
90. V. C. Özalp T. Schäfer Aptamer-Based Switchable Nanovalves for Stimuli-Responsive Drug Delivery Chem.-Eur. J. 2011 17 9893 9896
91. Y. Liu X. Ding J. Li Z. Luo Y. Hu J. Liu et al., Enzyme responsive drug delivery system based on mesoporous silica nanoparticles for tumor therapy in vivo Nanotechnology 2015 26 145102
92. D. P. Ferris Y.-L. Zhao N. M. Khashab H. A. Khatib J. F. Stoddart J. I. Zink Light-Operated Mechanized Nanoparticles J. Am. Chem. Soc. 2009 131 1686 1688
93. Y. Wang B. Li L. Zhang H. Song L. Zhang Targeted Delivery System Based on Magnetic Mesoporous Silica Nanocomposites with Light-Controlled Release Character ACS Appl. Mater. Interfaces 2012 5 11 15
94. Q. Yuan Y. Zhang T. Chen D. Lu Z. Zhao X. Zhang et al., Photon-Manipulated Drug Release from a Mesoporous Nanocontainer Controlled by Azobenzene-Modified Nucleic Acid ACS Nano 2012 6 6337 6344
95. C. Park K. Lee C. Kim Photoresponsive Cyclodextrin-Covered Nanocontainers and Their Sol-Gel Transition Induced by Molecular Recognition Angew. Chem., Int. Ed. 2009 48 1275 1278
96. N. K. Mal M. Fujiwara Y. Tanaka Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica Nature 2003 421 350 353
97. N.Z Knezevic B.G Trewyn V.SY. Lin Functionalized mesoporous silica nanoparticle-based visible light responsive controlled release delivery system Chem. Commun. 2011 47 2817 2819
98. J.L Vivero-Escoto I.I Slowing C.-W. Wu V.SY. Lin Photoinduced Intracellular Controlled Release Drug Delivery in Human Cells by Gold-Capped Mesoporous Silica Nanosphere J. Am. Chem. Soc. 2009 131 3462 3463
99. Q. Lin Q. Huang C. Li C. Bao Z. Liu F. Li et al., Anticancer Drug Release from a Mesoporous Silica Based Nanophotocage Regulated by Either a One- or Two-Photon Process J. Am. Chem. Soc. 2010 132 10645 10647
100. A. Schwarz S. Stander M. Berneburg M. Bohm D. Kulms H. van Steeg et al., Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair Nat. Cell Biol. 2002 4 26 31
101. P. Juzenas A. Juzeniene O. Kaalhus V. Iani J. Moan Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo Photochem. Photobiol. Sci. 2002 1 745 748
102. H. Liu D. Chen L. Li T. Liu L. Tan X. Wu et al., Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity Angew. Chem., Int. Ed. 2011 50 891 895
103. 2 with a smart polymer shell responsive to heat/near-infrared light for chemo-photothermal therapy J. Mater. Chem. 2012 22 16095 16103
104. W. Fang J. Yang J. Gong N. Zheng Photo-and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@Ag nanoparticles Adv. Funct. Mater. 2012 22 842 848
105. Q. Zhang N. Iwakuma P. Sharma B. M. Moudgil C. Wu J. McNeill et al., Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography Nanotechnology 2009 20 395102
106. Y. Xia W. Li C. M. Cobley J. Chen X. Xia Q. Zhang et al., Gold Nanocages: From Synthesis to Theranostic Applications Acc. Chem. Res. 2011 44 914 924
107. C.TH. Tran A. Kondyurin W. Chrzanowski M.MM. Bilek D.R McKenzie Influence of pH on yeast immobilization on polystyrene surfaces modified by energetic ion bombardment Colloids Surf., B 2013 104 145 152
108. J. You R. Zhang C. Xiong M. Zhong M. Melancon S. Gupta et al., Effective photothermal chemotherapy using doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors Cancer Res. 2012 72 4777 4786
109. M. C. Tan J. Y. Ying G. M. Chow Interfacial properties and in vitro cytotoxic effects of surface-modified near infrared absorbing Au-Au(2)S nanoparticles J. Mater. Sci.: Mater. Med. 2009 20 2091 2103
110. K. C. Leung S. Xuan X. Zhu D. Wang C. P. Chak S. F. Lee et al., Gold and iron oxide hybrid nanocomposite materials Chem. Soc. Rev. 2012 41 1911 1928
111. S. Shen H. Tang X. Zhang J. Ren Z. Pang D. Wang et al., Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation Biomaterials 2013 34 3150 3158
112. 4 nanoparticles: synergistic effect towards cancer therapy and imaging Nanotechnology 2013 24 065101
113. J. Chen C. Glaus R. Laforest Q. Zhang M. Yang M. Gidding et al., Gold nanocages as photothermal transducers for cancer treatment Small 2010 6 811 817
114. L. L. Fedoryshin A. J. Tavares E. Petryayeva S. Doughan U. J. Krull Near-Infrared-Triggered Anticancer Drug Release from Upconverting Nanoparticles ACS Appl. Mater. Interfaces 2014 6 13600 13606
115. W.-B. Pei B. Chen L. Wang J. Wu X. Teng R. Lau et al., NaF-mediated controlled-synthesis of multicolor Na x ScF 3+ x: Yb/Er upconversion nanocrystals Nanoscale 2015 7 4048 4054
116. J. Liu W. Bu L. Pan J. Shi NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica Angew. Chem., Int. Ed. 2013 52 4375 4379
117. E. Ruggiero J. Hernández-Gil J. C. Mareque-Rivas L. Salassa Near infrared activation of an anticancer Pt IV complex by Tm-doped upconversion nanoparticles Chem. Commun. 2015 51 2091 2094
118. Q. Chen C. Wang L. Cheng W. He Z. Cheng Z. Liu Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy Biomaterials 2014 35 2915 2923
119. C. Wang L. Cheng Z. Liu Upconversion nanoparticles for photodynamic therapy and other cancer therapeutics Theranostics 2013 3 317
120. X. Zhang G. Tian W. Yin L. Wang X. Zheng L. Yan et al., Controllable Generation of Nitric Oxide by Near-Infrared-Sensitized Upconversion Nanoparticles for Tumor Therapy Adv. Funct. Mater. 2015 25 3049 3056
121. J. Liu C. Wang X. Wang X. Wang L. Cheng Y. Li et al., Mesoporous Silica Coated Single-Walled Carbon Nanotubes as a Multifunctional Light-Responsive Platform for Cancer Combination Therapy Adv. Funct. Mater. 2015 25 384 392
122. W. Fan B. Shen W. Bu F. Chen Q. He K. Zhao et al., A smart upconversion-based mesoporous silica nanotheranostic system for synergetic chemo-/radio-/photodynamic therapy and simultaneous MR/UCL imaging Biomaterials 2014 35 8992 9002
123. H. Guo H. Qian N. M. Idris Y. Zhang Singlet oxygen-induced apoptosis of cancer cells using upconversion fluorescent nanoparticles as a carrier of photosensitizer Nanomedicine 2010 6 486 495
124. S. Dühnen T. Rinkel M. Haase Size control of nearly monodisperse β-NaGdF4 particles prepared from small α-NaGdF4 nanocrystals Chem. Mater. 2015 27 11 4033 4039
125. L. Cheng C. Wang Z. Liu Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy Nanoscale 2013 5 23 37
126. Y. Chen K. Ai J. Liu G. Sun Q. Yin L. Lu Multifunctional envelope-type mesoporous silica nanoparticles for pH-responsive drug delivery and magnetic resonance imaging Biomaterials 2015 60 111 120
127. S. Lu D. Tu P. Hu J. Xu R. Li M. Wang et al., Multifunctional Nano-Bioprobes Based on Rattle-Structured Upconverting Luminescent Nanoparticles Angew. Chem., Int. Ed. Engl. 2015 54 27 7915 7919
128. Y. Yang Y. Sun T. Cao J. Peng Y. Liu Y. Wu et al., Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging Biomaterials 2013 34 774 783
129. 4-based upconversion nanophosphors for trimodality imaging of NIR-to-NIR upconversion luminescence, X-Ray computed tomography and magnetic resonance Biomaterials 2012 33 5394 5405
130. H. Schäfer P. Ptacek O. Zerzouf M. Haase Synthesis and optical properties of KYF4/Yb, Er nanocrystals, and their surface modification with undoped KYF4 Adv. Funct. Mater. 2008 18 2913 2918
131. G. Tian X. Zheng X. Zhang W. Yin J. Yu D. Wang et al., TPGS-stabilized NaYbF 4: Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance Biomaterials 2015 40 107 116
132. Q. Ju X. Chen F. Ai D. Peng X. Lin W. Kong et al., An upconversion nanoprobe operating in the first biological window J. Mater. Chem. B 2015 3 3548 3555
133. S. Gayathri O.SN. Ghosh P. Sudhakara A.K Viswanath Chitosan conjugation: A facile approach to enhance the cell viability of LaF 3: Yb, Er upconverting nanotransducers in human breast cancer cells Carbohydr. Polym. 2015 121 302 308
134. 2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging ACS Nano 2012 6 8280 8287
135. N.-N. Dong M. Pedroni F. Piccinelli G. Conti A. Sbarbati J. E. Ramírez-Hernández et al., NIR-to-NIR two-photon excited CaF2: Tm3+, Yb3+ nanoparticles: multifunctional nanoprobes for highly penetrating fluorescence bio-imaging ACS Nano 2011 5 8665 8671
136. C. Zhang C. Li C. Peng R. Chai S. Huang D. Yang et al., Facile and controllable synthesis of monodisperse CaF2 and CaF2: Ce3+/Tb3+ hollow spheres as efficient luminescent materials and smart drug carriers Chem.-Eur. J. 2010 16 5672 5680
137. J. Wang F. Wang C. Wang Z. Liu X. Liu Single-Band Upconversion Emission in Lanthanide-Doped KMnF3 Nanocrystals Angew. Chem., Int. Ed. 2011 50 10369 10372
138. S. Gayathri O.SN. Ghosh A.K Viswanath P. Sudhakara M.JK. Reddy A. Shanmugharaj Synthesis of YF 3: Yb, Er upconverting nanofluorophores using chitosan and their cytotoxicity in MCF-7 cells Int. J. Biol. Macromol. 2015 72 1308 1312
139. X. Qiu T. Lin Multicolor Emission Tuning and Red/Green Ratio Enhancement of Yb 3/Er 3 Co-Doped KGdF4 Upconversion Nanoparticles J. Nanomater. 2015 501 361957
140. C. Wang H. Tao L. Cheng Z. Liu Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles Biomaterials 2011 32 6145 6154
141. X.-F. Qiao J.-C. Zhou J.-W. Xiao Y.-F. Wang L.-D. Sun C.-H. Yan Triple-functional core-shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro Nanoscale 2012 4 4611 4623
142. X. Li L. Zhou Y. Wei A. M. El-Toni F. Zhang D. Zhao Anisotropic Growth-Induced Synthesis of Dual-Compartment Janus Mesoporous Silica Nanoparticles for Bimodal Triggered Drugs Delivery J. Am. Chem. Soc. 2014 136 15086 15092
143. J. Zhou Z. Liu F. Li Upconversion nanophosphors for small-animal imaging Chem. Soc. Rev. 2012 41 1323 1349
144. G. Tian Z. Gu L. Zhou W. Yin X. Liu L. Yan et al., Mn2+ Dopant-Controlled Synthesis of NaYF4: Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery Adv. Mater. 2012 24 1226 1231
145. M. Wang G. Abbineni A. Clevenger C. Mao S. Xu Upconversion nanoparticles: synthesis, surface modification and biological applications Nanomedicine 2011 7 710 729
146. J. E. Kim J. Y. Shin M. H. Cho Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects Arch. Toxicol. 2012 86 685 700
147. Wahajuddin S. Arora Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers Int. J. Nanomed. 2012 7 3445 3471
148. J. H. Maeng D. H. Lee K. H. Jung Y. H. Bae I. S. Park S. Jeong et al., Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer Biomaterials 2010 31 4995 5006
149. P.-J. Chen S.-H. Hu C.-S. Hsiao Y.-Y. Chen D.-M. Liu S.-Y. Chen Multifunctional magnetically removable nanogated lids of Fe3O4-capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging J. Mater. Chem. 2011 21 2535 2543
150. J. E. Lee N. Lee H. Kim J. Kim S. H. Choi J. H. Kim et al., Uniform Mesoporous Dye-Doped Silica Nanoparticles Decorated with Multiple Magnetite Nanocrystals for Simultaneous Enhanced Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery J. Am. Chem. Soc. 2009 132 552 557
151. C. R. Thomas D. P. Ferris J.-H. Lee E. Choi M. H. Cho E. S. Kim et al., Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles J. Am. Chem. Soc. 2010 132 10623 10625
152. E. Bringas O. Koysuren D. V. Quach M. Mahmoudi E. Aznar J. D. Roehling et al., Triggered release in lipid bilayer-capped mesoporous silica nanoparticles containing SPION using an alternating magnetic field Chem. Commun. 2012 48 5647 5649
153. E. Ruiz-Hernández A. Baeza M. Vallet-Regí Smart Drug Delivery through DNA/Magnetic Nanoparticle Gates ACS Nano 2011 5 1259 1266
154. B. Chang X. Sha J. Guo Y. Jiao C. Wang W. Yang Thermo and pH dual responsive, polymer shell coated, magnetic mesoporous silica nanoparticles for controlled drug release J. Mater. Chem. 2011 21 9239 9247
155. R. Casasús E. Climent M. D. Marcos R. Martínez-Máñez F. Sancenón J. Soto et al., Dual Aperture Control on pH- and Anion-Driven Supramolecular Nanoscopic Hybrid Gate-like Ensembles J. Am. Chem. Soc. 2008 130 1903 1917
156. S. Angelos Y.-W. Yang N. M. Khashab J. F. Stoddart J. I. Zink Dual-Controlled Nanoparticles Exhibiting AND Logic J. Am. Chem. Soc. 2009 131 11344 11346
157. S. Wu X. Huang X. Du Glucose- and pH-Responsive Controlled Release of Cargo from Protein-Gated Carbohydrate-Functionalized Mesoporous Silica Nanocontainers Angew. Chem., Int. Ed. 2013 52 5580 5584
158. Q. He J. Zhang J. Shi Z. Zhu L. Zhang W. Bu et al., The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses Biomaterials 2010 31 6 1085 1092
159. G. Quan X. Pan Z. Wang Q. Wu G. Li L. Dian et al., Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery J. Nanobiotechnol. 2015 13 7