Online 2D-LC-MS/MS Assay to Quantify Therapeutic Protein in Human Serum in the Presence of Pre-existing Antidrug Antibodies

Analytical Chemistry

Volumn 87, Issue 16, 2015, Pages 8555-8563

  Shen, Yinghua ^a   Zhang, Guodong ^a   Yang, Jinsong ^a   Qiu, Yongchang ^a   McCauley, Thomas ^a   Pan, Luying ^a   Wu, Jiang ^a  

^a Bioanalytical and Biomarker Development Research and Nonclinical Development Shire ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CHEMICAL ANALYSIS; DRUG PRODUCTS; ISOTOPES; MASS SPECTROMETRY; PEPTIDES; PROTEINS; QUALITY CONTROL; SOCIAL NETWORKING (ONLINE); SODIUM DODECYL SULFATE; SODIUM SULFATE;

BIOANALYTICAL METHODS; CHEMICAL REDUCTION; COEFFICIENT OF VARIATION; DATA INTERPRETATION; INTERNAL STANDARDS; MULTIPLE REACTION MONITORING; PRECISE MEASUREMENTS; THERAPEUTIC PROTEIN;

ANTIBODIES;

ANTIBODY; CARBON; DODECYL SULFATE SODIUM; IGA-SPECIFIC SERINE ENDOPEPTIDASE; PEPTIDE; SERINE PROTEINASE;

BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOLOGY; ISOTOPE LABELING; STANDARD; STANDARDS; TANDEM MASS SPECTROMETRY;

ANTIBODIES; CARBON ISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; ISOTOPE LABELING; PEPTIDES; REFERENCE STANDARDS; SERINE ENDOPEPTIDASES; SODIUM DODECYL SULFATE; TANDEM MASS SPECTROMETRY;

EID: 84939818143     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/acs.analchem.5b02293     Document Type: Article

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