Absolute quantification of a therapeutic domain antibody using ultra-performance liquid chromatography-â€"mass spectrometry and immunoassay

Bioanalysis

Volumn 2, Issue 9, 2010, Pages 1597-1608

  Szapacs, Matthew E ^a   Urbanski, James J ^a   Kehler, Jonathan R ^a   Wilson, Robert ^b   Boram, Sharon L ^a   Hottenstein, Charles S ^a   Citerone, David R ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOMAIN ANTIBODY; PEPTIDE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN G; TRYPSIN;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; FEMALE; HAPLORHINI; IMMUNOASSAY; LIMIT OF QUANTITATION; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; STRUCTURE ANALYSIS; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; BLOOD ANALYSIS; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MACACA FASCICULARIS; METABOLISM; METHODOLOGY; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, INHALATION; ANIMALS; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; IMMUNOASSAY; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; TANDEM MASS SPECTROMETRY; TRYPSIN;

EID: 79952497246     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.10.70     Document Type: Article

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