Clinical pharmacokinetic assessment of an anti-MAdCAM monoclonal antibody therapeutic by LC-MS/MS

Analytical Chemistry

Volumn 84, Issue 14, 2012, Pages 5959-5967

  Fernández Ocaña, Mireia ^a   James, Ian T ^b   Kabir, Musarat ^b   Grace, Christopher ^b   Yuan, Guojun ^a   Martin, Steven W ^a   Neubert, Hendrik ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL APPROACH; ANTI-IDIOTYPIC ANTIBODIES; CLINICAL PHARMACOKINETICS; CLINICAL STUDY; EXTENDED SEQUENCES; HIGHLY-CORRELATED; IMMUNOAFFINITY; LC-MS/MS; LIGHT CHAIN; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MAGNETIC BEADS; MONOCLONAL ANTIBODIES (MAB); PARAMETER ESTIMATE; PHARMACOKINETIC ANALYSIS; PROTEIN G; SERUM CONCENTRATION; STABLE ISOTOPES; STREPTAVIDIN; TRYPSIN DIGESTION; ULCERATIVE COLITIS;

ANTIGEN-ANTIBODY REACTIONS; BODY FLUIDS; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; PARAMETER ESTIMATION; PEPTIDES; PHARMACOKINETICS;

ASSAYS;

MONOCLONAL ANTIBODY; MUCOPROTEIN;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; IMMUNOASSAY; IMMUNOLOGY; LIQUID CHROMATOGRAPHY; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL; TANDEM MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; HUMANS; IMMUNOASSAY; MUCOPROTEINS; TANDEM MASS SPECTROMETRY;

EID: 84863978008     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac300600f     Document Type: Article

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