A multiplexed hybrid LC-MS/MS pharmacokinetic assay to measure two co-administered monoclonal antibodies in a clinical study

Bioanalysis

Volumn 6, Issue 13, 2014, Pages 1781-1794

  Xu, Keyang ^a   Liu, Luna ^a   Maia, Mauricio ^a   Li, Jenny ^a   Lowe, John ^a   Song, An ^a   Kaur, Surinder ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IDIOTYPIC ANTIBODY REAGENT; MONOCLONAL ANTIBODY; PEPTIDE; REAGENT; UNCLASSIFIED DRUG; IMMUNOGLOBULIN LIGHT CHAIN; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; CALIBRATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; ISOTOPE LABELING; LIGAND BINDING; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MEASUREMENT ACCURACY; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; AMINO ACID SEQUENCE; BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; QUALITY CONTROL; STANDARDS;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; ISOTOPE LABELING; MOLECULAR SEQUENCE DATA; PEPTIDES; QUALITY CONTROL; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY;

EID: 84906670997     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.14.142     Document Type: Article

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