Simple and efficient digestion of a monoclonal antibody in serum using pellet digestion: Comparison with traditional digestion methods in LC-MS/MS bioanalysis

Bioanalysis

Volumn 4, Issue 24, 2012, Pages 2887-2896

  Yuan, Long ^a   Arnold, Mark E ^a   Aubry, Anne Françoise ^a   Ji, Qin C ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PEPTIDE;

ALKYLATION; ANALYSIS; ANIMAL TISSUE; ARTICLE; BIOANALYSIS; CONTROLLED STUDY; DENATURATION; DISULFIDE BOND; HAPLORHINI; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; NONHUMAN; PELLET DIGESTION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; REDUCTION; RELIABILITY; SERUM; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; HAPLORHINI; HUMANS; TANDEM MASS SPECTROMETRY;

EID: 84871283549     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.284     Document Type: Article

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