Generic automated method for liquid chromatography-multiple reaction monitoring mass spectrometry based monoclonal antibody quantitation for preclinical pharmacokinetic studies

Analytical Chemistry

Volumn 86, Issue 17, 2014, Pages 8776-8784

  Zhang, Qian ^a   Spellman, Daniel S ^a   Song, Yaoli ^a   Choi, Bernard ^a   Hatcher, Nathan G ^a   Tomazela, Daniela ^a   Beaumont, Maribel ^a   Tabrizifard, Mohammad ^a   Prabhavalkar, Deepa ^a   Seghezzi, Wolfgang ^a   Harrelson, Jane ^a   Bateman, Kevin P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

BIOPHARMACEUTICAL DEVELOPMENT; CYNOMOLGUS MONKEYS; INTERNAL STANDARDS; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS/MS); METHOD DEVELOPMENT; PHARMACOKINETIC STUDIES; REACTION MONITORING; THERAPEUTIC MONOCLONAL ANTIBODIES;

MONOCLONAL ANTIBODIES;

ANTIBODIES, MONOCLONAL; IMMUNOGLOBULIN G; PEPTIDES;

AMINO ACID SEQUENCE; ANIMALS; BLOOD; BLOOD CHEMICAL ANALYSIS; CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HALF-LIFE; IMMUNOPRECIPITATION; INSTRUMENTATION; ISOTOPE LABELING; MACACA FASCICULARIS; METABOLISM; MOLECULAR SEQUENCE DATA; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HALF-LIFE; IMMUNOGLOBULIN G; IMMUNOPRECIPITATION; ISOTOPE LABELING; MACACA FASCICULARIS; MOLECULAR SEQUENCE DATA; PEPTIDES; TANDEM MASS SPECTROMETRY;

EID: 84906861531     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac5019827     Document Type: Article

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