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Volumn 88, Issue 2, 2015, Pages 347-356

Role of G protein-coupled receptor kinases 2 and 3 in μ-opioid receptor desensitization and internalization

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDE DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; MU OPIATE RECEPTOR;

EID: 84939806217     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.115.098293     Document Type: Article
Times cited : (67)

References (40)
  • 2
    • 84863134139 scopus 로고    scopus 로고
    • Desensitization and trafficking of μ-opioid receptors in locus ceruleus neurons: Modulation by kinases
    • Arttamangkul S, Lau EK, Lu HW, and Williams JT (2012) Desensitization and trafficking of μ-opioid receptors in locus ceruleus neurons: modulation by kinases. Mol Pharmacol 81:348-355.
    • (2012) Mol Pharmacol , vol.81 , pp. 348-355
    • Arttamangkul, S.1    Lau, E.K.2    Lu, H.W.3    Williams, J.T.4
  • 3
    • 0345305690 scopus 로고    scopus 로고
    • Mu-opioidreceptor desensitization in mature rat neurons: Lack of interaction between DAMGO and morphine
    • Bailey CP, Couch D, Johnson E, Griffiths K, Kelly E, and Henderson G (2003) Mu-opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine. J Neurosci 23:10515-10520.
    • (2003) J Neurosci , vol.23 , pp. 10515-10520
    • Bailey, C.P.1    Couch, D.2    Johnson, E.3    Griffiths, K.4    Kelly, E.5    Henderson, G.6
  • 4
    • 9444274109 scopus 로고    scopus 로고
    • Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons
    • Bailey CP, Kelly E, and Henderson G (2004) Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons. Mol Pharmacol 66:1592-1598.
    • (2004) Mol Pharmacol , vol.66 , pp. 1592-1598
    • Bailey, C.P.1    Kelly, E.2    Henderson, G.3
  • 5
    • 58449100187 scopus 로고    scopus 로고
    • Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons
    • Bailey CP, Llorente J, Gabra BH, Smith FL, Dewey WL, Kelly E, and Henderson G (2009a) Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons. Eur J Neurosci 29:307-318.
    • (2009) Eur J Neurosci , vol.29 , pp. 307-318
    • Bailey, C.P.1    Llorente, J.2    Gabra, B.H.3    Smith, F.L.4    Dewey, W.L.5    Kelly, E.6    Henderson, G.7
  • 8
    • 0021990306 scopus 로고
    • An operational model of pharmacological agonism: The effect of E/[A] curve shape on agonist dissociation constant estimation
    • Black JW, Leff P, Shankley NP, and Wood J (1985) An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation. Br J Pharmacol 84:561-571.
    • (1985) Br J Pharmacol , vol.84 , pp. 561-571
    • Black, J.W.1    Leff, P.2    Shankley, N.P.3    Wood, J.4
  • 10
    • 10044280635 scopus 로고    scopus 로고
    • Mu-opioid receptor desensitization: Is morphine different?
    • Connor M, Osborne PB, and Christie MJ (2004) Mu-opioid receptor desensitization: is morphine different? Br J Pharmacol 143:685-696.
    • (2004) Br J Pharmacol , vol.143 , pp. 685-696
    • Connor, M.1    Osborne, P.B.2    Christie, M.J.3
  • 11
    • 0033599014 scopus 로고    scopus 로고
    • ERK activation induces phosphorylationof Elk-1 at multiple S/T-P motifs to high stoichiometry
    • Cruzalegui FH, Cano E, and Treisman R (1999) ERK activation induces phosphorylationof Elk-1 at multiple S/T-P motifs to high stoichiometry. Oncogene 18:7948-7957.
    • (1999) Oncogene , vol.18 , pp. 7948-7957
    • Cruzalegui, F.H.1    Cano, E.2    Treisman, R.3
  • 12
    • 63849297063 scopus 로고    scopus 로고
    • Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons
    • Dang VC, Napier IA, and Christie MJ (2009) Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. J Neurosci 29:3322-3327.
    • (2009) J Neurosci , vol.29 , pp. 3322-3327
    • Dang, V.C.1    Napier, I.A.2    Christie, M.J.3
  • 13
    • 80051615294 scopus 로고    scopus 로고
    • Agonist-selective patterns of μ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies
    • Doll C, Konietzko J, Pöll F, Koch T, Höllt V, and Schulz S (2011) Agonist-selective patterns of μ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies. Br J Pharmacol 164:298-307.
    • (2011) Br J Pharmacol , vol.164 , pp. 298-307
    • Doll, C.1    Konietzko, J.2    Pöll, F.3    Koch, T.4    Höllt, V.5    Schulz, S.6
  • 14
    • 84867802836 scopus 로고    scopus 로고
    • Deciphering μ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells
    • Doll C, Pöll F, Peuker K, Loktev A, Glück L, and Schulz S (2012) Deciphering μ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells. Br J Pharmacol 167:1259-1270.
    • (2012) Br J Pharmacol , vol.167 , pp. 1259-1270
    • Doll, C.1    Pöll, F.2    Peuker, K.3    Loktev, A.4    Glück, L.5    Schulz, S.6
  • 15
    • 0035500377 scopus 로고    scopus 로고
    • Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain
    • Erdtmann-Vourliotis M, Mayer P, Ammon S, Riechert U, and Höllt V (2001) Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain. Brain Res Mol Brain Res 95:129-137.
    • (2001) Brain Res Mol Brain Res , vol.95 , pp. 129-137
    • Erdtmann-Vourliotis, M.1    Mayer, P.2    Ammon, S.3    Riechert, U.4    Höllt, V.5
  • 16
    • 34548755067 scopus 로고    scopus 로고
    • Assay of protein kinases using radiolabeled ATP: A protocol
    • Hastie CJ, McLauchlan HJ, and Cohen P (2006) Assay of protein kinases using radiolabeled ATP: a protocol. Nat Protoc 1:968-971.
    • (2006) Nat Protoc , vol.1 , pp. 968-971
    • Hastie, C.J.1    McLauchlan, H.J.2    Cohen, P.3
  • 17
    • 84911869231 scopus 로고    scopus 로고
    • Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor
    • Homan KT, Wu E, Cannavo A, Koch WJ, and Tesmer JJ (2014a) Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor. Molecules 19:16937-16949.
    • (2014) Molecules , vol.19 , pp. 16937-16949
    • Homan, K.T.1    Wu, E.2    Cannavo, A.3    Koch, W.J.4    Tesmer, J.J.5
  • 18
    • 84891839423 scopus 로고    scopus 로고
    • Structural and functional analysis of G protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog
    • Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, and Tesmer JJ (2014b) Structural and functional analysis of G protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol Pharmacol 85:237-248.
    • (2014) Mol Pharmacol , vol.85 , pp. 237-248
    • Homan, K.T.1    Wu, E.2    Wilson, M.W.3    Singh, P.4    Larsen, S.D.5    Tesmer, J.J.6
  • 19
    • 77249125513 scopus 로고    scopus 로고
    • The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy
    • Hull LC, Llorente J, Gabra BH, Smith FL, Kelly E, Bailey C, Henderson G, and Dewey WL (2010) The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy. J Pharmacol Exp Ther 332:1127-1135.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 1127-1135
    • Hull, L.C.1    Llorente, J.2    Gabra, B.H.3    Smith, F.L.4    Kelly, E.5    Bailey, C.6    Henderson, G.7    Dewey, W.L.8
  • 20
    • 0037161582 scopus 로고    scopus 로고
    • Rational design and evaluation of new lead compound structures for selective betaARK1 inhibitors
    • Iino M, Furugori T, Mori T, Moriyama S, Fukuzawa A, and Shibano T (2002) Rational design and evaluation of new lead compound structures for selective betaARK1 inhibitors. J Med Chem 45:2150-2159.
    • (2002) J Med Chem , vol.45 , pp. 2150-2159
    • Iino, M.1    Furugori, T.2    Mori, T.3    Moriyama, S.4    Fukuzawa, A.5    Shibano, T.6
  • 21
    • 79960249008 scopus 로고    scopus 로고
    • Cardiotonic agent comprising GRK inhibitor
    • inventors, Takeda Pharmaceutical Co. Ltd., Ikeda S, Keneko M, Fujiwara S, assignees. International patent WO 2007 Mar 29
    • Ikeda S, Keneko M, and Fujiwara S (2007) inventors, Takeda Pharmaceutical Co. Ltd., Ikeda S, Keneko M, Fujiwara S, assignees. Cardiotonic agent comprising GRK inhibitor. International patent WO 2007034846. 2007 Mar 29.
    • (2007)
    • Ikeda, S.1    Keneko, M.2    Fujiwara, S.3
  • 24
    • 40349114499 scopus 로고    scopus 로고
    • Agonist-selective mechanisms of GPCR desensitization
    • Kelly E, Bailey CP, and Henderson G (2008) Agonist-selective mechanisms of GPCR desensitization. Br J Pharmacol 153 (Suppl 1):S379-S388.
    • (2008) Br J Pharmacol , vol.153 , pp. S379-S388
    • Kelly, E.1    Bailey, C.P.2    Henderson, G.3
  • 25
    • 0035048317 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 mediates mu-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus
    • Li AH and Wang HL (2001) G protein-coupled receptor kinase 2 mediates mu-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus. J Neurochem 77:435-444.
    • (2001) J Neurochem , vol.77 , pp. 435-444
    • Li, A.H.1    Wang, H.L.2
  • 27
    • 0025250147 scopus 로고
    • Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors
    • Lohse MJ, Benovic JL, Caron MG, and Lefkowitz RJ (1990) Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem 265:3202-3211.
    • (1990) J Biol Chem , vol.265 , pp. 3202-3211
    • Lohse, M.J.1    Benovic, J.L.2    Caron, M.G.3    Lefkowitz, R.J.4
  • 30
    • 33748535402 scopus 로고    scopus 로고
    • Distinct clathrin-coated pits sort different G protein-coupled receptor cargo
    • Mundell SJ, Luo J, Benovic JL, Conley PB, and Poole AW (2006) Distinct clathrin-coated pits sort different G protein-coupled receptor cargo. Traffic 7:1420-1431.
    • (2006) Traffic , vol.7 , pp. 1420-1431
    • Mundell, S.J.1    Luo, J.2    Benovic, J.L.3    Conley, P.B.4    Poole, A.W.5
  • 31
    • 0021891147 scopus 로고
    • On the potassium conductance increased by opioids in rat locus coeruleus neurones
    • North RA and Williams JT (1985) On the potassium conductance increased by opioids in rat locus coeruleus neurones. J Physiol 364:265-280.
    • (1985) J Physiol , vol.364 , pp. 265-280
    • North, R.A.1    Williams, J.T.2
  • 32
    • 79953003987 scopus 로고    scopus 로고
    • Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone
    • Quillinan N, Lau EK, Virk M, von Zastrow M, and Williams JT (2011) Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone. J Neurosci 31:4434-4443.
    • (2011) J Neurosci , vol.31 , pp. 4434-4443
    • Quillinan, N.1    Lau, E.K.2    Virk, M.3    Von Zastrow, M.4    Williams, J.T.5
  • 33
    • 79251506646 scopus 로고    scopus 로고
    • Nonenzymatic rapid control of GIRK channel function by a G protein-coupled receptor kinase
    • Raveh A, Cooper A, Guy-David L, and Reuveny E (2010) Nonenzymatic rapid control of GIRK channel function by a G protein-coupled receptor kinase. Cell 143:750-760.
    • (2010) Cell , vol.143 , pp. 750-760
    • Raveh, A.1    Cooper, A.2    Guy-David, L.3    Reuveny, E.4
  • 35
    • 84862294189 scopus 로고    scopus 로고
    • ERK1/2 MAP kinases: Structure, function, and regulation
    • Roskoski R, Jr (2012) ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol Res 66:105-143.
    • (2012) Pharmacol Res , vol.66 , pp. 105-143
    • Roskoski, R.1
  • 36
    • 80052038573 scopus 로고    scopus 로고
    • β-Arrestin-mediated receptor trafficking and signal transduction
    • Shenoy SK and Lefkowitz RJ (2011) β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci 32:521-533.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 521-533
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 38
    • 79960223285 scopus 로고    scopus 로고
    • Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors
    • Thal DM, Yeow RY, Schoenau C, Huber J, and Tesmer JJ (2011) Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharmacol 80:294-303.
    • (2011) Mol Pharmacol , vol.80 , pp. 294-303
    • Thal, D.M.1    Yeow, R.Y.2    Schoenau, C.3    Huber, J.4    Tesmer, J.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.