One hundred ways to kill a podocyte

Nephrology Dialysis Transplantation

Volumn 30, Issue 8, 2015, Pages 1266-1271

  Saleem, Moin A ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

endothelial; endothelin; integrin; mesangial; nephrotic; podocyte

Indexed keywords

COMPLEMENT FACTOR H; CYTOSKELETON PROTEIN; ENDOTHELIN 1; EPHRIN B2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTEGRIN; NEPHRIN; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TETRASPANIN; UBIDECARENONE; VASCULOTROPIN;

CELL ADHESION; CELL DISRUPTION; CELL FUNCTION; CELL KILLING; CELL MATURATION; COMPLEMENT ACTIVATION; CONGENITAL NEPHROTIC SYNDROME; ENDOTHELIUM CELL; GENE; GLOMERULUS BASEMENT MEMBRANE; HUMAN; MESANGIUM CELL; MITOCHONDRIAL MEMBRANE; NONHUMAN; NPHS1 GENE; PARACRINE SIGNALING; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL; REVIEW; SHEAR FLOW; SHEAR STRESS; SOMATIC CELL GENETICS; ANIMAL; APOPTOSIS; GLOMERULUS; KIDNEY DISEASE; PATHOLOGY;

ANIMALS; APOPTOSIS; HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; PODOCYTES;

EID: 84939641932     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfu363     Document Type: Review

References (61)

1. Harvey SJ, Jarad G, Cunningham J et al. Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Nephrol 2008; 19: 2150-2158
2. Kato H, Gruenwald A, Suh JH et al. Wnt/beta-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 2011; 286: 26003-26015
3. Boute N, Gribouval O, Roselli S et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 2000; 24: 349-354
4. Kestila M, Lenkkeri U, Mannikko M et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1: 575-582
5. Eremina V, Sood M, Haigh J et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003; 111: 707-716
6. Lenoir O, Milon M, Virsolvy A et al. Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. J Am Soc Nephrol 2014; 25: 1050-1062
7. Simonson MS. Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375-411
8. Majumdar A, Drummond IA. Podocyte differentiation in the absence of endothelial cells as revealed in the zebrafish avascular mutant, cloche. Dev Genet 1999; 24: 220-229
9. Kikkawa Y, Virtanen I, Miner JH. Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. J Cell Biol 2003; 161: 187-196
10. Schlondorff D, Banas B. The mesangial cell revisited: no cell is an island. J Am Soc Nephrol 2009; 20: 1179-1187
11. Lindahl P, Johansson BR, Leveen P et al. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997; 277: 242-245
12. Foo SS, Turner CJ, Adams S et al. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 2006; 124: 161-173
13. Costantini F, Kopan R. Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Develop Cell 2010; 18: 698-712
14. Kreidberg JA. Podocyte differentiation and glomerulogenesis. J Am Soc Nephrol 2003; 14: 806-814
15. Saleem MA, Zavadil J, Bailly M et al. The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells. Am J Physiol Renal Physiol 2008; 295: F959-F970
16. Brunskill EW, Georgas K, Rumballe B et al. Defining the molecular character of the developing and adult kidney podocyte. PLoS One 2011; 6: e24640
17. Rastaldi MP, Armelloni S, Berra S et al. Glomerular podocytes contain neuron-like functional synaptic vesicles. FASEB J 2006; 20: 976-978
18. Lennon R, Byron A, Humphries JD et al. Global analysis reveals the complexity of the human glomerular extracellular matrix. J Am Soc Nephrol 2014; 25: 939-951
19. Byron A, Randles MJ, Humphries JD et al. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. J Am Soc Nephrol 2014; 25: 953-966
20. Sachs N, Sonnenberg A. Cell-matrix adhesion of podocytes in physiology and disease. Nat Rev Nephrol 2013; 9: 200-210
21. Calderwood DA, Shattil SJ, Ginsberg MH. Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem 2000; 275: 22607-22610
22. Kretzler M, Teixeira VP, Unschuld PG et al. Integrin-linked kinase as a candidate downstream effector in proteinuria. FASEB J 2001; 15: 1843-1845
23. Welsh GI, Saleem MA. The podocyte cytoskeleton-key to a functioning glomerulus in health and disease. Nat Rev Nephrol 2011; 8: 14-21
24. Pozzi A, Jarad G, Moeckel GW et al. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Develop Biol 2008; 316: 288-301
25. Reiser J, von Gersdorff G, Loos M et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 2004; 113: 1390-1397
26. Yu CC, Fornoni A, Weins A et al. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med 2013; 369: 2416-2423
27. Potla U, Ni J, Vadaparampil J et al. Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest 2014; 124: 1757-1769
28. Karamatic Crew V, Burton N, Kagan A et al. CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. Blood 2004; 104: 2217-2223
29. Zenker M, Aigner T, Wendler O et al. Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet 2004; 13: 2625-2632
30. Pozzi A, Zent R. Integrins in kidney disease. J Am Soc Nephrol 2013; 24: 1034-1039
31. Wei C, Moller CC, Altintas MMet al. Modification of kidney barrier function by the urokinase receptor. Nat Med 2008; 14: 55-63
32. Wei C, El Hindi S, Li J et al. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med 2011; 17: 952-960
33. Calderwood DA. Integrin activation. J Cell Sci 2004; 117: 657-666
34. Tian X, Kim JJ, Monkley SM et al. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance. J Clin Invest 2014; 124: 1098-1113
35. Coward RJ, Welsh GI, Yang J et al. The human glomerular podocyte is a novel target for insulin action. Diabetes 2005; 54: 3095-3102
36. Heeringa SF, Chernin G, Chaki M et al. COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 2011; 121: 2013-2024
37. Ashraf S, Gee HY, Woerner S et al. ADCK4 mutations promote steroidresistant nephrotic syndrome through CoQ10 biosynthesis disruption. J Clin Invest 2013; 123: 5179-5189
38. McCarthy HJ, Saleem MA. Genetics in clinical practice: nephrotic and proteinuric syndromes. Nephron Exp Nephrol 2011; 118: e1-e8
39. Lopez LC, Schuelke M, Quinzii CM et al. Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am J Hum Genet 2006; 79: 1125-1129
40. Salviati L, Sacconi S, Murer L et al. Infantile encephalomyopathy and nephropathy with CoQ10 deficiency: a CoQ10-responsive condition. Neurology 2005; 65: 606-608
41. Buscher AK, Weber S. Educational paper: the podocytopathies. Eur J Pediatr 2012; 171: 1151-1160
42. Hinkes B, Wiggins RC, Gbadegesin R et al. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet 2006; 38: 1397-1405
43. Winn MP, Conlon PJ, Lynn KL et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 2005; 308: 1801-1804
44. Gee HY, Ashraf S, Wan X et al. Mutations in EMP2 cause childhoodonset nephrotic syndrome. Am J Human Genet 2014; 94: 884-890
45. Morrison AA, Viney RL, Saleem MA et al. New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes. Am J Physiol Renal Physiol 2008; 295: F12-F17
46. Natoli TA, Liu J, Eremina V et al. A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. J Am Soc Nephrol 2002; 13: 2058-2067
47. Sanyanusin P, Schimmenti LA, McNoe LA et al. Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. Nat Genet 1995; 9: 358-364
48. Barua M, Stellacci E, Stella L et al. Mutations in PAX2 Associate with Adult-Onset FSGS. J Am Soc Nephrol 2014; 25: 1942-1953
49. Gebeshuber CA, Kornauth C, Dong L et al. Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nat Med 2013; 19: 481-487
50. Harris JJ, McCarthy HJ, Ni L et al. Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1. J Pathol 2013; 229: 660-671
51. Coward RJ, Foster RR, Patton D et al. Nephrotic plasma alters slit diaphragm- dependent signaling and translocates nephrin, podocin, and CD2 associated protein in cultured human podocytes. J Am Soc Nephrol 2005; 16: 629-637
52. Babayeva S, Miller M, Zilber Y et al. Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes. Pediatr Nephrol 2011; 26: 1071-1081
53. Bitzan M, Babayeva S, Vasudevan A et al. TNFalpha pathway blockade ameliorates toxic effects of FSGS plasma on podocyte cytoskeleton and beta3 integrin activation. Pediatr Nephrol 2012; 27: 2217-2226
54. Welsh GI, Hale LJ, Eremina V et al. Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab 2010; 12: 329-340
55. Eremina V, Quaggin SE. The role of VEGF-A in glomerular development and function. Curr Opin Nephrol Hypertension 2004; 13: 9-15
56. Daehn I, Casalena G, Zhang T et al. Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis. J Clin Invest 2014; 124: 1608-1621
57. Kurts C, Panzer U, Anders HJ et al. The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol 2013; 13: 738-753
58. Alexander JJ, Wang Y, Chang A et al. Mouse podocyte complement factor H: the functional analog to human complement receptor 1. J Am Soc Nephrol 2007; 18: 1157-1166
59. Huber TB, Hartleben B, Winkelmann K et al. Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol 2009; 20: 798-806
60. Abe Y, Sakairi T, Kajiyama H et al. Bioenergetic characterization of mouse podocytes. Am J Physiol Cell Physiol 2010; 299: C464-C476
61. Hartleben B, Godel M, Meyer-Schwesinger C et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 2010; 120: 1084-1096