Altered energy state reversibly controls smooth muscle contractile function in human saphenous vein during acute hypoxia-reoxygenation: Role of glycogen, AMP-activated protein kinase, and insulin-independent glucose uptake

Biochemical Pharmacology

Volumn 97, Issue 1, 2015, Pages 77-88

  Pyla, Rajkumar ^a,b   Pichavaram, Prahalathan ^a,b   Fairaq, Arwa ^a,b   Park, Mary Anne ^c   Kozak, Mark ^d   Kamath, Vinayak ^e   Patel, Vijay S ^e   Segar, Lakshman ^a,b,d,e  

^a UNIVERSITY OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c AUGUSTA UNIVERSITY   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

AMPK; Glycogen; Hypoxia; Serotonin; Vascular smooth muscle

Indexed keywords

BETA ACTIN; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; GLYCOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA; INSULIN; LEVO GLUCOSE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POTASSIUM CHLORIDE; PROTEIN KINASE B; SEROTONIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CELL ENERGY; CELL HYPOXIA; CELL STRESS; CONTROLLED STUDY; ENDOTHELIUM; EX VIVO STUDY; FEMALE; GLUCOSE TRANSPORT; GLYCOGEN ANALYSIS; HUMAN; HUMAN TISSUE; MALE; MIDDLE AGED; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REOXYGENATION; SAPHENOUS VEIN; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE TONE; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION; AGED; ALLOSTASIS; ANALOGS AND DERIVATIVES; ANIMAL; ENZYME ACTIVATION; ENZYMOLOGY; GLYCOGENOLYSIS; HEART MUSCLE ISCHEMIA; IN VITRO STUDY; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN PROCESSING; THORACIC AORTA; TRANSPORT AT THE CELLULAR LEVEL; VASOCONSTRICTION; WISTAR RAT;

AGED; ALLOSTASIS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA, THORACIC; BIOLOGICAL TRANSPORT; CELL HYPOXIA; ENZYME ACTIVATION; FEMALE; GLUCOSE; GLYCOGEN; GLYCOGENOLYSIS; HUMANS; IN VITRO TECHNIQUES; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL ISCHEMIA; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS, WISTAR; SAPHENOUS VEIN; VASOCONSTRICTION;

EID: 84939564337     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.06.036     Document Type: Article

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