Metformin exaggerates phenylephrine-induced AMPK phosphorylation independent of CaMKKβ and attenuates contractile response in endothelium-denuded rat aorta

Biochemical Pharmacology

Volumn 92, Issue 2, 2014, Pages 266-279

  Pyla, Rajkumar ^a,b   Osman, Islam ^a,b   Pichavaram, Prahalathan ^a,b   Hansen, Paul ^a,b   Segar, Lakshman ^a,b,c,d  

^a AUGUSTA UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

AMPK; CaMKK ; Metformin; Phenylephrine; Vascular smooth muscle

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PHENYLEPHRINE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EX VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION; TANDEM MASS SPECTROMETRY; VASCULAR RING; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; DRUG POTENTIATION; ENZYMOLOGY; METABOLISM; ORGAN CULTURE TECHNIQUE; PHOSPHORYLATION; PHYSIOLOGY; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; WISTAR RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA, THORACIC; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; MALE; METFORMIN; ORGAN CULTURE TECHNIQUES; PHENYLEPHRINE; PHOSPHORYLATION; RATS; RATS, WISTAR; VASOCONSTRICTION;

EID: 84908334295     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.08.024     Document Type: Article

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