메뉴 건너뛰기




Volumn 300, Issue 1, 2011, Pages

Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent

Author keywords

5 aminoimidazole 4 carboxamide 1 D ribofuranoside; Adenosine 5 monophosphate activated protein kinase; Endothelium derived contracting factors; Nitric oxide; Spontaneously hypertensive rats; Wistar Kyoto rats

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ADENINE NUCLEOTIDE; ENDOPEROXIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROSTAGLANDIN SYNTHASE;

EID: 78651285381     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00597.2010     Document Type: Article
Times cited : (40)

References (59)
  • 1
    • 66249144962 scopus 로고    scopus 로고
    • Increased participation of vasoconstrictor prostanoids from COX-2 in phenylephrine response in aorta from hypertensive rats
    • Alvarez Y. Increased participation of vasoconstrictor prostanoids from COX-2 in phenylephrine response in aorta from hypertensive rats. J Hypertens 22: S126-S127, 2004.
    • (2004) J Hypertens , vol.22
    • Alvarez, Y.1
  • 2
    • 33947515200 scopus 로고    scopus 로고
    • AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein
    • Blume C, Benz PM, Walter U, Ha J, Kemp BE, Renne T. AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem 282: 4601-4612, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 4601-4612
    • Blume, C.1    Benz, P.M.2    Walter, U.3    Ha, J.4    Kemp, B.E.5    Renne, T.6
  • 5
    • 0242581695 scopus 로고    scopus 로고
    • Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    • Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278: 45021-45026, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 45021-45026
    • Chen, H.1    Montagnani, M.2    Funahashi, T.3    Shimomura, I.4    Quon, M.J.5
  • 10
    • 85047689953 scopus 로고
    • 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
    • Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-Aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229: 558-565, 1995.
    • (1995) Eur J Biochem , vol.229 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 11
    • 33645319245 scopus 로고    scopus 로고
    • Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: Involvement of P2 receptors and adenosine transporters
    • da Silva CG, Jarzyna R, Specht A, Kaczmarek E. Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters. Circ Res 98: e39-e47, 2006.
    • (2006) Circ Res , vol.98
    • Da Silva, C.G.1    Jarzyna, R.2    Specht, A.3    Kaczmarek, E.4
  • 12
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • Davis BJ, Xie Z, Viollet B, Zou MH. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 55: 496-505, 2006.
    • (2006) Diabetes , vol.55 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3    Zou, M.H.4
  • 13
    • 77951841400 scopus 로고    scopus 로고
    • RhoA-Rho kinase signaling mediates endothelium- and endoperoxide- dependent contractile activities characteristic of hypertensive vascular dysfunction
    • Denniss SG, Jeffery AJ, Rush JW. RhoA-Rho kinase signaling mediates endothelium- and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction. Am J Physiol Heart Circ Physiol 298: H1391-H1405, 2010.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Denniss, S.G.1    Jeffery, A.J.2    Rush, J.W.3
  • 14
    • 66249106732 scopus 로고    scopus 로고
    • Impaired hemodynamics and endothelial vasomotor function via endoperoxide-mediated vasoconstriction in the carotid artery of spontaneously hypertensive rats
    • Denniss SG, Rush JW. Impaired hemodynamics and endothelial vasomotor function via endoperoxide-mediated vasoconstriction in the carotid artery of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 296: H1038-H1047, 2009.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Denniss, S.G.1    Rush, J.W.2
  • 15
    • 0032724583 scopus 로고    scopus 로고
    • Decreased basal despite enhanced agonist-stimulated effects of nitric oxide in 12-week-old stroke-prone spontaneously hypertensive rats
    • Dowell FJ, Martin W, Dominiczak AF, Hamilton CA. Decreased basal despite enhanced agonist-stimulated effects of nitric oxide in 12-week-old stroke-prone spontaneously hypertensive rats. Eur J Pharmacol 379: 175-182, 1999.
    • (1999) Eur J Pharmacol , vol.379 , pp. 175-182
    • Dowell, F.J.1    Martin, W.2    Dominiczak, A.F.3    Hamilton, C.A.4
  • 16
    • 0029924483 scopus 로고    scopus 로고
    • Inhibition of smooth muscle cell calcium mobilization and aortic ring contraction by lactone vastatins
    • Escobales N, Crespo MJ, Altieri PI, Furilla RA. Inhibition of smooth muscle cell calcium mobilization and aortic ring contraction by lactone vastatins. J Hypertens 14: 115-121, 1996.
    • (1996) J Hypertens , vol.14 , pp. 115-121
    • Escobales, N.1    Crespo, M.J.2    Altieri, P.I.3    Furilla, R.A.4
  • 19
    • 68049103917 scopus 로고    scopus 로고
    • Activation and signaling by the AMP-activated protein kinase in endothelial cells
    • Fisslthaler B, Fleming I. Activation and signaling by the AMP-activated protein kinase in endothelial cells. Circ Res 105: 114-127, 2009.
    • (2009) Circ Res , vol.105 , pp. 114-127
    • Fisslthaler, B.1    Fleming, I.2
  • 20
    • 27144465277 scopus 로고    scopus 로고
    • Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells
    • Fleming I, Fisslthaler B, Dixit M, Busse R. Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells. J Cell Sci 118: 4103-4111, 2005.
    • (2005) J Cell Sci , vol.118 , pp. 4103-4111
    • Fleming, I.1    Fisslthaler, B.2    Dixit, M.3    Busse, R.4
  • 21
    • 31644451872 scopus 로고    scopus 로고
    • Glutathione depletion in vivo enhances contraction and attenuates endothelium-dependent relaxation of isolated rat aorta
    • Ford RJ, Graham DA, Denniss SG, Quadrilatero J, Rush JWE. Glutathione depletion in vivo enhances contraction and attenuates endothelium-dependent relaxation of isolated rat aorta. Free Radic Biol Med 40: 670-678, 2006.
    • (2006) Free Radic Biol Med , vol.40 , pp. 670-678
    • Ford, R.J.1    Graham, D.A.2    Denniss, S.G.3    Quadrilatero, J.4    Rush, J.W.E.5
  • 23
    • 70350129736 scopus 로고    scopus 로고
    • Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats
    • Graham DA, Rush JW. Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats. J Appl Physiol 107: 1059-1067, 2009.
    • (2009) J Appl Physiol , vol.107 , pp. 1059-1067
    • Graham, D.A.1    Rush, J.W.2
  • 24
    • 2442689237 scopus 로고    scopus 로고
    • Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats
    • Graham DA, Rush JWE. Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J Appl Physiol 96: 2088-2096, 2004.
    • (2004) J Appl Physiol , vol.96 , pp. 2088-2096
    • Graham, D.A.1    Rush, J.W.E.2
  • 25
    • 0024503289 scopus 로고
    • Operation Everest II: Muscle energetics during maximal exhaustive exercise
    • Green HJ, Sutton J, Young P, Cymerman A, Houston CS. Operation Everest II: muscle energetics during maximal exhaustive exercise. J Appl Physiol 66: 142-150, 1989.
    • (1989) J Appl Physiol , vol.66 , pp. 142-150
    • Green, H.J.1    Sutton, J.2    Young, P.3    Cymerman, A.4    Houston, C.S.5
  • 26
    • 0036841861 scopus 로고    scopus 로고
    • NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels
    • Hamilton CA, Brosnan MJ, Al Benna S, Berg G, Dominiczak AF. NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension 40: 755-762, 2002.
    • (2002) Hypertension , vol.40 , pp. 755-762
    • Hamilton, C.A.1    Brosnan, M.J.2    Al Benna, S.3    Berg, G.4    Dominiczak, A.F.5
  • 27
    • 33748314466 scopus 로고    scopus 로고
    • Increased myosin light chain kinase expression in hypertension: Regulation by serum response factor via an insertion mutation in the promoter
    • Han YJ, Hu WY, Chernaya O, Antic N, Gu L, Gupta M, Piano M, de Lanerolle P. Increased myosin light chain kinase expression in hypertension: regulation by serum response factor via an insertion mutation in the promoter. Mol Biol Cell 17: 4039-4050, 2006.
    • (2006) Mol Biol Cell , vol.17 , pp. 4039-4050
    • Han, Y.J.1    Hu, W.Y.2    Chernaya, O.3    Antic, N.4    Gu, L.5    Gupta, M.6    Piano, M.7    De Lanerolle, P.8
  • 28
    • 0038199737 scopus 로고    scopus 로고
    • Management of cellular energy by the AMP-activated protein kinase system
    • Hardie DG, Scott JW, Pan DA, Hudson ER. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546: 113-120, 2003.
    • (2003) FEBS Lett , vol.546 , pp. 113-120
    • Hardie, D.G.1    Scott, J.W.2    Pan, D.A.3    Hudson, E.R.4
  • 29
    • 0035844241 scopus 로고    scopus 로고
    • Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation
    • Harris MB, Ju H, Venema VJ, Liang H, Zou R, Michell BJ, Chen ZP, Kemp BE, Venema RC. Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation. J Biol Chem 276: 16587-16591, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 16587-16591
    • Harris, M.B.1    Ju, H.2    Venema, V.J.3    Liang, H.4    Zou, R.5    Michell, B.J.6    Chen, Z.P.7    Kemp, B.E.8    Venema, R.C.9
  • 30
    • 0024341462 scopus 로고
    • Cellular calcium regulation in hypertension
    • Hermsmeyer K, Erne P. Cellular calcium regulation in hypertension. Am J Hypertens 2: 655-658, 1989.
    • (1989) Am J Hypertens , vol.2 , pp. 655-658
    • Hermsmeyer, K.1    Erne, P.2
  • 32
    • 0020329051 scopus 로고
    • Determination of adenine nucleotides and inosine in human myocard by ion-pair reversed-phase high-performance liquid chromatography
    • Ingebretsen OC, Bakken AM, Segadal L, Farstad M. Determination of adenine nucleotides and inosine in human myocard by ion-pair reversed-phase high-performance liquid chromatography. J Chromatogr 242: 119-126, 1982.
    • (1982) J Chromatogr , vol.242 , pp. 119-126
    • Ingebretsen, O.C.1    Bakken, A.M.2    Segadal, L.3    Farstad, M.4
  • 33
    • 0034471646 scopus 로고    scopus 로고
    • Direct vascular effects of HMG-CoA reductase inhibitors
    • Laufs U, Liao JK. Direct vascular effects of HMG-CoA reductase inhibitors. Trends Cardiovasc Med 10: 143-148, 2000.
    • (2000) Trends Cardiovasc Med , vol.10 , pp. 143-148
    • Laufs, U.1    Liao, J.K.2
  • 35
    • 34547124878 scopus 로고    scopus 로고
    • Agonist-modulated regulation of AMP-activated protein kinase in endothelial cells: Evidence for an AMPK-Rac1-Akt-eNOS pathway
    • Levine YC, Li GK, Michel T. Agonist-modulated regulation of AMP-activated protein kinase in endothelial cells: evidence for an AMPK-Rac1-Akt-eNOS pathway. J Biol Chem 282: 20351-20364, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 20351-20364
    • Levine, Y.C.1    Li, G.K.2    Michel, T.3
  • 36
    • 70349633673 scopus 로고    scopus 로고
    • Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin
    • Li XN, Song J, Zhang L, LeMaire SA, Hou X, Zhang C, Coselli JS, Chen L, Wang XL, Zhang Y, Shen YH. Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes 58: 2246-2257, 2009.
    • (2009) Diabetes , vol.58 , pp. 2246-2257
    • Li, X.N.1    Song, J.2    Zhang, L.3    LeMaire, S.A.4    Hou, X.5    Zhang, C.6    Coselli, J.S.7    Chen, L.8    Wang, X.L.9    Zhang, Y.10    Shen, Y.H.11
  • 37
    • 33646070557 scopus 로고    scopus 로고
    • Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats
    • Majithiya JB, Balaraman R. Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats. Life Sci 78: 2615-2624, 2006.
    • (2006) Life Sci , vol.78 , pp. 2615-2624
    • Majithiya, J.B.1    Balaraman, R.2
  • 38
    • 33847684285 scopus 로고    scopus 로고
    • Mechanisms underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats
    • Matsumoto T, Noguchi E, Kobayashi T, Kamata K. Mechanisms underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats. Free Radic Biol Med 42: 993-1007, 2007.
    • (2007) Free Radic Biol Med , vol.42 , pp. 993-1007
    • Matsumoto, T.1    Noguchi, E.2    Kobayashi, T.3    Kamata, K.4
  • 39
    • 51349118085 scopus 로고    scopus 로고
    • Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat
    • Michel FS, Man GS, Man RY, Vanhoutte PM. Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat. Br J Pharmacol 155: 217-226, 2008.
    • (2008) Br J Pharmacol , vol.155 , pp. 217-226
    • Michel, F.S.1    Man, G.S.2    Man, R.Y.3    Vanhoutte, P.M.4
  • 40
    • 0041355355 scopus 로고    scopus 로고
    • Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells
    • Morrow VA, Foufelle F, Connell JM, Petrie JR, Gould GW, Salt IP. Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem 278: 31629-31639, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 31629-31639
    • Morrow, V.A.1    Foufelle, F.2    Connell, J.M.3    Petrie, J.R.4    Gould, G.W.5    Salt, I.P.6
  • 43
    • 3342915617 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation
    • Nagata D, Takeda R, Sata M, Satonaka H, Suzuki E, Nagano T, Hirata Y. AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. Circulation 110: 444-451, 2004.
    • (2004) Circulation , vol.110 , pp. 444-451
    • Nagata, D.1    Takeda, R.2    Sata, M.3    Satonaka, H.4    Suzuki, E.5    Nagano, T.6    Hirata, Y.7
  • 45
    • 22544442185 scopus 로고    scopus 로고
    • Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin
    • Perez-Guerrero C, Marquez-Martin A, Herrera MD, Marhuenda E, Alvarez DS. Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin. Pharmacology 74: 209-215, 2005.
    • (2005) Pharmacology , vol.74 , pp. 209-215
    • Perez-Guerrero, C.1    Marquez-Martin, A.2    Herrera, M.D.3    Marhuenda, E.4    Alvarez, D.S.5
  • 46
    • 34548825944 scopus 로고    scopus 로고
    • Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha
    • Qiang W, Weiqiang K, Qing Z, Pengju Z, Yi L. Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha. Exp Mol Med 39: 535-543, 2007.
    • (2007) Exp Mol Med , vol.39 , pp. 535-543
    • Qiang, W.1    Weiqiang, K.2    Qing, Z.3    Pengju, Z.4    Yi, L.5
  • 47
    • 30144435427 scopus 로고    scopus 로고
    • Aging influences multiple indices of oxidative stress in the aortic media of the Fischer 344/NNia x Brown Norway/BiNia rat
    • Rice KM, Preston DL, Walker EM, Bough ER. Aging influences multiple indices of oxidative stress in the aortic media of the Fischer 344/NNia x Brown Norway/BiNia rat. Free Radic Res 40: 185-197, 2006.
    • (2006) Free Radic Res , vol.40 , pp. 185-197
    • Rice, K.M.1    Preston, D.L.2    Walker, E.M.3    Bough, E.R.4
  • 50
    • 34147152841 scopus 로고    scopus 로고
    • Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
    • DOI 10.1042/BJ20061520
    • Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigation of the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 403: 139-148, 2007. (Pubitemid 46569875)
    • (2007) Biochemical Journal , vol.403 , Issue.1 , pp. 139-148
    • Sanders, M.J.1    Grondin, P.O.2    Hegarty, B.D.3    Snowden, M.A.4    Carling, D.5
  • 51
    • 21544469973 scopus 로고    scopus 로고
    • Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase
    • Schulz E, Anter E, Zou MH, Keaney JF Jr. Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase. Circulation 111: 3473-3480, 2005.
    • (2005) Circulation , vol.111 , pp. 3473-3480
    • Schulz, E.1    Anter, E.2    Zou, M.H.3    Keaney Jr., J.F.4
  • 52
    • 33845949733 scopus 로고    scopus 로고
    • Dissecting the role of 5′-AMP for allosteric stimulation, activation and deactivation of AMP-activated protein kinase
    • Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D. Dissecting the role of 5′-AMP for allosteric stimulation, activation and deactivation of AMP-activated protein kinase. J Biol Chem 281: 32207-32216, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 32207-32216
    • Suter, M.1    Riek, U.2    Tuerk, R.3    Schlattner, U.4    Wallimann, T.5    Neumann, D.6
  • 53
    • 4344628605 scopus 로고    scopus 로고
    • Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt
    • Thors B, Halldorsson H, Thorgeirsson G. Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt. FEBS Lett 573: 175-180, 2004.
    • (2004) FEBS Lett , vol.573 , pp. 175-180
    • Thors, B.1    Halldorsson, H.2    Thorgeirsson, G.3
  • 54
    • 14844320534 scopus 로고    scopus 로고
    • Endothelium-dependent contractions in hypertension
    • Vanhoutte PM, Feletou M, Taddei S. Endothelium-dependent contractions in hypertension. Br J Pharmacol 144: 449-458, 2005.
    • (2005) Br J Pharmacol , vol.144 , pp. 449-458
    • Vanhoutte, P.M.1    Feletou, M.2    Taddei, S.3
  • 55
    • 68049129864 scopus 로고    scopus 로고
    • In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I
    • Wang S, Xu J, Song P, Viollet B, Zou MH. In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I. Diabetes 58: 1893-1901, 2009.
    • (2009) Diabetes , vol.58 , pp. 1893-1901
    • Wang, S.1    Xu, J.2    Song, P.3    Viollet, B.4    Zou, M.H.5
  • 56
    • 77950989801 scopus 로고    scopus 로고
    • AMPKα2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo
    • Wang S, Zhang M, Liang B, Xu J, Xie Z, Lui C, Viollet B, Yan D, Zou MH. AMPKα2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo. Circ Res 106: 1117-1128, 2010.
    • (2010) Circ Res , vol.106 , pp. 1117-1128
    • Wang, S.1    Zhang, M.2    Liang, B.3    Xu, J.4    Xie, Z.5    Lui, C.6    Viollet, B.7    Yan, D.8    Zou, M.H.9
  • 57
    • 0032792665 scopus 로고    scopus 로고
    • AMP-activated protein kinase, a metabolic master switch: Possible roles in Type 2 diabetes
    • Winder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes. Am J Physiol Endocrinol Metab 277: E1-E10, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Winder, W.W.1    Hardie, D.G.2
  • 58
    • 12144271041 scopus 로고    scopus 로고
    • Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition
    • Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia 47: 2012-2021, 2004.
    • (2004) Diabetologia , vol.47 , pp. 2012-2021
    • Yu, X.1    McCorkle, S.2    Wang, M.3    Lee, Y.4    Li, J.5    Saha, A.K.6    Unger, R.H.7    Ruderman, N.B.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.