Vitamin D and estrogen synergy in Vdr-expressing CD4+ T cells is essential to induce Helios+FoxP3+ T cells and prevent autoimmune demyelinating disease

Journal of Neuroimmunology

Volumn 286, Issue , 2015, Pages 48-58

  Spanier, Justin A ^b   Nashold, Faye E ^a   Mayne, Christopher G ^c   Nelson, Corwin D ^d   Hayes, Colleen E ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c VITERBO UNIVERSITY   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

Estrogen; Experimental autoimmune encephalomyelitis; HeliosFoxP3 T cells; Multiple sclerosis; Prevention; Vitamin D

Indexed keywords

CALCITRIOL; COLECALCIFEROL; ESTROGEN; TRANSCRIPTION FACTOR FOXP3; CALCITRIOL RECEPTOR; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT; TRANSCRIPTION FACTOR; VITAMIN D; ZFPN1A2 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ESTROGEN BLOOD LEVEL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE INACTIVATION; GENOTYPE; IN VITRO STUDY; INCIDENCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; RISK REDUCTION; TH1 CELL; TH17 CELL; UTERUS WEIGHT; VDR GENE; VITAMIN DEFICIENCY; WILD TYPE; ANIMAL; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OVARIECTOMY; PATHOLOGY; PREGNANCY; TIME; TRANSGENIC MOUSE; UTERUS;

ANIMALS; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DRUG SYNERGISM; ESTROGENS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN VITRO TECHNIQUES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; OVARIECTOMY; PEPTIDE FRAGMENTS; PREGNANCY; RECEPTORS, CALCITRIOL; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSCRIPTION FACTORS; UTERUS; VITAMIN D;

EID: 84939490075     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2015.06.015     Document Type: Article

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