-
1
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase
-
Bi L, Okabe I, Bernard DJ, Wynshaw-Boris A, and Nussbaum RL (1999) Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase. J Biol Chem 274:10963-10968.
-
(1999)
J Biol Chem
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Wynshaw-Boris, A.4
Nussbaum, R.L.5
-
2
-
-
2942527148
-
Akt decreases lymphocyte apoptosis and improves survival in sepsis
-
Bommhardt U, Chang KC, Swanson PE, Wagner TH, Tinsley KW, Karl IE, and Hotchkiss RS (2004) Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol 172:7583-7591.
-
(2004)
J Immunol
, vol.172
, pp. 7583-7591
-
-
Bommhardt, U.1
Chang, K.C.2
Swanson, P.E.3
Wagner, T.H.4
Tinsley, K.W.5
Karl, I.E.6
Hotchkiss, R.S.7
-
3
-
-
0025201426
-
Purification and characterization of phosphoinositide 3-kinase from rat liver
-
Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, and Cantley LC (1990) Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem 265:19704-19711.
-
(1990)
J Biol Chem
, vol.265
, pp. 19704-19711
-
-
Carpenter, C.L.1
Duckworth, B.C.2
Auger, K.R.3
Cohen, B.4
Schaffhausen, B.S.5
Cantley, L.C.6
-
4
-
-
15444369648
-
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice. A pro-inflammatory role for eNOS-derived NO in vivo
-
Connelly L, Madhani M, and Hobbs AJ (2005) Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice. A pro-inflammatory role for eNOS-derived NO in vivo. J Biol Chem 280:10040-10046.
-
(2005)
J Biol Chem
, vol.280
, pp. 10040-10046
-
-
Connelly, L.1
Madhani, M.2
Hobbs, A.J.3
-
5
-
-
0029807471
-
Akt is a direct target of the phosphatidylinositol 3-kinase: Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells
-
Datta K, Bellacosa A, Chan TO, and Tsichlis PN (1996) Akt is a direct target of the phosphatidylinositol 3-kinase: activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. J Biol Chem 271:30835-30839.
-
(1996)
J Biol Chem
, vol.271
, pp. 30835-30839
-
-
Datta, K.1
Bellacosa, A.2
Chan, T.O.3
Tsichlis, P.N.4
-
6
-
-
0034908652
-
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI3-kinase/Akt pathway
-
Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, Rütten H, Fichtlscherer S, Martin H, and Zeiher AM (2001) HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI3-kinase/Akt pathway. J Clin Investig 108:391-397.
-
(2001)
J Clin Investig
, vol.108
, pp. 391-397
-
-
Dimmeler, S.1
Aicher, A.2
Vasa, M.3
Mildner-Rihm, C.4
Adler, K.5
Tiemann, M.6
Rütten, H.7
Fichtlscherer, S.8
Martin, H.9
Zeiher, A.M.10
-
7
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells via Akt-dependent phosphorylation
-
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, and Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells via Akt-dependent phosphorylation. Nature (Lond) 399:601-605.
-
(1999)
Nature (Lond)
, vol.399
, pp. 601-605
-
-
Dimmeler, S.1
Fleming, I.2
Fisslthaler, B.3
Hermann, C.4
Busse, R.5
Zeiher, A.M.6
-
8
-
-
0033542414
-
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
-
Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, and Sessa WC (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature (Lond) 399:597-601.
-
(1999)
Nature (Lond)
, vol.399
, pp. 597-601
-
-
Fulton, D.1
Gratton, J.P.2
McCabe, T.J.3
Fontana, J.4
Fujio, Y.5
Walsh, K.6
Franke, T.F.7
Papapetropoulos, A.8
Sessa, W.C.9
-
10
-
-
0025120211
-
Regulation of the mevalonate pathway
-
Goldstein JL and Brown MS (1990) Regulation of the mevalonate pathway. Nature (Lond) 343:425-430.
-
(1990)
Nature (Lond)
, vol.343
, pp. 425-430
-
-
Goldstein, J.L.1
Brown, M.S.2
-
11
-
-
0037199972
-
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
-
Guha M and Mackman N (2002) The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 277:32124-32132.
-
(2002)
J Biol Chem
, vol.277
, pp. 32124-32132
-
-
Guha, M.1
Mackman, N.2
-
12
-
-
0031015986
-
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin domain
-
Klippel A, Kavanaugh WM, Pot D, and Williams LT (1997) A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin domain. Mol Cell Biol 17:338-344.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 338-344
-
-
Klippel, A.1
Kavanaugh, W.M.2
Pot, D.3
Williams, L.T.4
-
13
-
-
0033826581
-
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
-
Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, Sessa WC, and Walsh K (2000) The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 6:1004-1010.
-
(2000)
Nat Med
, vol.6
, pp. 1004-1010
-
-
Kureishi, Y.1
Luo, Z.2
Shiojima, I.3
Bialik, A.4
Fulton, D.5
Lefer, D.J.6
Sessa, W.C.7
Walsh, K.8
-
14
-
-
0034533147
-
Statins as a newly recognized type of immunomodulator
-
Kwak B, Mulhaupt F, Myit S, and Mach F (2000) Statins as a newly recognized type of immunomodulator. Nat Med 6:1399-1402.
-
(2000)
Nat Med
, vol.6
, pp. 1399-1402
-
-
Kwak, B.1
Mulhaupt, F.2
Myit, S.3
Mach, F.4
-
15
-
-
0033800718
-
Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice
-
Laufs U, Gertz K, Huang P, Nickenig G, Böhm M, Dirnagl U, and Endres M (2000) Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke 31:2437-2449.
-
(2000)
Stroke
, vol.31
, pp. 2437-2449
-
-
Laufs, U.1
Gertz, K.2
Huang, P.3
Nickenig, G.4
Böhm, M.5
Dirnagl, U.6
Endres, M.7
-
16
-
-
0031451344
-
Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
-
Laufs U, La Fata V, and Liao JK (1997) Inhibition of 3-hydroxy-3- methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J Biol Chem 272:31725-31729.
-
(1997)
J Biol Chem
, vol.272
, pp. 31725-31729
-
-
Laufs, U.1
La Fata, V.2
Liao, J.K.3
-
17
-
-
0032584177
-
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
-
Laufs U, La Fata V, Plutzky J, and Liao JK (1998) Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 97:1129-1135.
-
(1998)
Circulation
, vol.97
, pp. 1129-1135
-
-
Laufs, U.1
La Fata, V.2
Plutzky, J.3
Liao, J.K.4
-
18
-
-
4444369432
-
Simvastatin induced heme oxygenase-1. A novel mechanism of vessel protection
-
Lee T-S, Chang C-C, Zhu Y, and Shyy Y-J (2004) Simvastatin induced heme oxygenase-1. A novel mechanism of vessel protection. Circulation 110:1296-1302.
-
(2004)
Circulation
, vol.110
, pp. 1296-1302
-
-
Lee, T.-S.1
Chang, C.-C.2
Zhu, Y.3
Shyy, Y.-J.4
-
19
-
-
0037109101
-
Statins as potent antiinflammatory drugs
-
Lefer DJ (2002) Statins as potent antiinflammatory drugs. Circulation 106:2041-2042.
-
(2002)
Circulation
, vol.106
, pp. 2041-2042
-
-
Lefer, D.J.1
-
21
-
-
0032777785
-
Diabetes-induced down-regulation of β1-adrenoceptor mRNA expression in rat heart
-
Matsuda N, Hattori Y, Gando S, Akaishi Y, Kemmotsu O, and Kanno M (1999) Diabetes-induced down-regulation of β1-adrenoceptor mRNA expression in rat heart. Biochem Pharmacol 58:881-885.
-
(1999)
Biochem Pharmacol
, vol.58
, pp. 881-885
-
-
Matsuda, N.1
Hattori, Y.2
Gando, S.3
Akaishi, Y.4
Kemmotsu, O.5
Kanno, M.6
-
23
-
-
8644270552
-
Therapeutic effect of in vivo transfection of transcription factor decoy to NF-κB on septic lung in mice
-
Matsuda N, Hattori Y, Takahashi Y, Nishihira J, Jesmin S, Kobayashi M, and Gando S (2004) Therapeutic effect of in vivo transfection of transcription factor decoy to NF-κB on septic lung in mice. Am J Physiol 287:L1248-L1255.
-
(2004)
Am J Physiol
, vol.287
-
-
Matsuda, N.1
Hattori, Y.2
Takahashi, Y.3
Nishihira, J.4
Jesmin, S.5
Kobayashi, M.6
Gando, S.7
-
25
-
-
2642553075
-
HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis
-
Merx MW, Liehn EA, Janssens U, Lütticken R, Schrader J, Hanrath P, and Weber C (2004) HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis. Circulation 109:2560-2565.
-
(2004)
Circulation
, vol.109
, pp. 2560-2565
-
-
Merx, M.W.1
Liehn, E.A.2
Janssens, U.3
Lütticken, R.4
Schrader, J.5
Hanrath, P.6
Weber, C.7
-
26
-
-
0025883342
-
Nitric oxide: Physiology, pathophysiology, and pharmacology
-
Moncada S, Palmer PMJ, and Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142.
-
(1991)
Pharmacol Rev
, vol.43
, pp. 109-142
-
-
Moncada, S.1
Palmer, P.M.J.2
Higgs, E.A.3
-
27
-
-
0035313040
-
Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of β-catenin
-
Monick MM, Carter AB, Robeff PK, Flaherty DM, Peterson MW, and Hunninghake GW (2001) Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of β-catenin. J Immunol 166:4713-4720.
-
(2001)
J Immunol
, vol.166
, pp. 4713-4720
-
-
Monick, M.M.1
Carter, A.B.2
Robeff, P.K.3
Flaherty, D.M.4
Peterson, M.W.5
Hunninghake, G.W.6
-
28
-
-
15744384639
-
Endothelial dysfunction and hypercontractility of vascular myocytes are ameliorated by fluvastatin in obese Zucker rats
-
Nishimatsu H, Suzuki E, Satonaka H, Takeda R, Omata M, Fujita T, Nagai R, Kitamura T, and Hirata Y (2005) Endothelial dysfunction and hypercontractility of vascular myocytes are ameliorated by fluvastatin in obese Zucker rats. Am J Physiol 288:1770-1776.
-
(2005)
Am J Physiol
, vol.288
, pp. 1770-1776
-
-
Nishimatsu, H.1
Suzuki, E.2
Satonaka, H.3
Takeda, R.4
Omata, M.5
Fujita, T.6
Nagai, R.7
Kitamura, T.8
Hirata, Y.9
-
29
-
-
0033548627
-
Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokine-stimulated C6 glial cells
-
Pahan K, Raymond JR, and Singh I (1999) Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokine-stimulated C6 glial cells. J Biol Chem 274:7528-7536.
-
(1999)
J Biol Chem
, vol.274
, pp. 7528-7536
-
-
Pahan, K.1
Raymond, J.R.2
Singh, I.3
-
30
-
-
0031587403
-
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages
-
Park YC, Lee CH, Kang HS, Chung HT, and Kim HD (1997) Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages. Biochem Biophys Res Commun 240:692-696.
-
(1997)
Biochem Biophys Res Commun
, vol.240
, pp. 692-696
-
-
Park, Y.C.1
Lee, C.H.2
Kang, H.S.3
Chung, H.T.4
Kim, H.D.5
-
32
-
-
0033517190
-
NF-kB is a target of AKT in anti-apoptotic PDGF signaling
-
Romashkova JA and Makarov SS (1999) NF-kB is a target of AKT in anti-apoptotic PDGF signaling. Nature (Lond) 401:86-90.
-
(1999)
Nature (Lond)
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
33
-
-
0029825613
-
Elevated blood pressure in mice lacking endothelial nitric oxide synthase
-
Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, and Smithies O (1996) Elevated blood pressure in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci USA 93:13176-13181.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13176-13181
-
-
Shesely, E.G.1
Maeda, N.2
Kim, H.S.3
Desai, K.M.4
Krege, J.H.5
Laubach, V.E.6
Sherman, P.A.7
Sessa, W.C.8
Smithies, O.9
-
34
-
-
0037216678
-
HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells
-
Skaletz-Rorowski A, Lutchman M, Kureishi Y, Lefer DJ, Faust JR, and Walsh K (2003) HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells. Cardiovasc Res 57:253-264.
-
(2003)
Cardiovasc Res
, vol.57
, pp. 253-264
-
-
Skaletz-Rorowski, A.1
Lutchman, M.2
Kureishi, Y.3
Lefer, D.J.4
Faust, J.R.5
Walsh, K.6
-
35
-
-
0033055969
-
Involvement of both the tyrosine kinase and the phosphatidylinositol- 3′ kinase signal transduction pathways in the regulation of lipoprotein lipase expression in J774.2 macrophages by cytokines and lipopolysaccharide
-
Tengku-Muhammad TS, Hughes TR, Cryer A, and Ramji DP (1999) Involvement of both the tyrosine kinase and the phosphatidylinositol-3′ kinase signal transduction pathways in the regulation of lipoprotein lipase expression in J774.2 macrophages by cytokines and lipopolysaccharide. Cytokine 11:463-468.
-
(1999)
Cytokine
, vol.11
, pp. 463-468
-
-
Tengku-Muhammad, T.S.1
Hughes, T.R.2
Cryer, A.3
Ramji, D.P.4
-
36
-
-
0032928083
-
Nitric oxide in septic shock
-
Titheradge MA (1999) Nitric oxide in septic shock. Biochim Biophys Acta 1411:437-455.
-
(1999)
Biochim Biophys Acta
, vol.1411
, pp. 437-455
-
-
Titheradge, M.A.1
-
37
-
-
0033604577
-
Signaling by distinct classes of phosphoinositide 3-kinases
-
Vanhaesebroeck B and Waterfield MD (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 253:239-254.
-
(1999)
Exp Cell Res
, vol.253
, pp. 239-254
-
-
Vanhaesebroeck, B.1
Waterfield, M.D.2
-
38
-
-
17744400708
-
Effects of statins on endothelium and endothelial progenitor cell recruitment
-
Walter DH, Dimmeler S, and Zeiher AM (2004) Effects of statins on endothelium and endothelial progenitor cell recruitment. Semin Vasc Med 4:385-393.
-
(2004)
Semin Vasc Med
, vol.4
, pp. 385-393
-
-
Walter, D.H.1
Dimmeler, S.2
Zeiher, A.M.3
-
39
-
-
0033994015
-
Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase
-
Yamashita T, Kawashima S, Ohashi Y, Ozaki M, Ueyama T, Ishida T, Inoue N, Hirata K, Akita H, and Yokoyama M (2000) Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase. Circulation 101:931-937.
-
(2000)
Circulation
, vol.101
, pp. 931-937
-
-
Yamashita, T.1
Kawashima, S.2
Ohashi, Y.3
Ozaki, M.4
Ueyama, T.5
Ishida, T.6
Inoue, N.7
Hirata, K.8
Akita, H.9
Yokoyama, M.10
-
40
-
-
0037131377
-
N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A
-
Yellaturu CR, Bhanoori M, Neeli I, and Rao GN (2002) N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A. J Biol Chem 277:40148-40155.
-
(2002)
J Biol Chem
, vol.277
, pp. 40148-40155
-
-
Yellaturu, C.R.1
Bhanoori, M.2
Neeli, I.3
Rao, G.N.4
|