Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III

British Journal of Anaesthesia

Volumn 104, Issue 2, 2010, Pages 183-190

  McGown, C C ^a   Brown, N J ^a   Hellewell, P G ^a   Reilly, C S ^a   Brookes, Z L S ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Complications, endotoxaemia; Microcirculation; Pharmacology, nitric oxide

Indexed keywords

ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRITE; PRAVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL TONE; CELL INTERACTION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; HYPOTENSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEISURE; LEUKOCYTE ADHERENCE; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; MICROANGIOPATHY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEPSIS; UPREGULATION;

EID: 76749152023     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep361     Document Type: Article

References (36)

1. van Amersfoort ES, van Berkel TJC, Kuiper J. Receptors, mediators and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev 2003; 16: 379-414
2. Giusti-Paiva A, Martinez MR, Felix JV, et al. Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats. Shock 2004; 21: 271-275
3. Vo PA, Lad B, Tomlinson JA, Francis S, Ahluwalia A. Autoregulatory role of endothelium-derived nitric oxide (NO) on lipopolysaccharide-induced vascular inducible NO synthase expression and function. J Biol Chem 2005; 280: 7236-7243
4. Connelly L, Madhani M, Hobbs AJ. Resistance to endotoxic shock in endothelial nitric-oxide synthase (NOSII) knock-out mice: a pro-inflammatory role for NOSII-derived NO in vivo. J Biol Chem 2005; 280: 10040-10046
5. Scicluna JK, Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZL. Reduced vascular response to phenylephrine during exposure to lipopolysaccharide in vitro involves nitric oxide and endothelin 1. Shock 2008; 29: 417-421
6. Matsuda N, Hayashi Y, Takahashi Y, Hattori Y. Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 2006; 319: 1348-1354
7. Garrean S, Gao XP, Brovkovych V, et al. Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide. J Immunol 2006; 177: 4853-4860
8. Tyml K, Li F, Wilson JX. Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism. Crit Care Med 2008; 36: 2355-2362
9. Bommhardt U, Chang KC, Swanson PE, et al. Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol 2004; 172: 7583-7591
10. West of Scotland Coronary Prevention Study Group. Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 1998; 21: 1440-1445
11. Merx MW, Liehn EA, Graf J, et al. Statin treatment after onset of sepsis in a murine model improves survival. Circulation 2005; 112: 117-124
12. Brookes ZL, Brown NJ, Reilly CS. Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage. Br J Anaesth 2002; 88: 255-263
13. Brookes ZL, Kaufman S. Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat in vivo. J Physiol 2005; 565: 269-277
14. Andrew PS, Kaufman S. Splenic denervation worsens lipopolysaccharide- induced hypotension, hemoconcentration, and hypovolemia. Am J Physiol Regul Integr Comp Physiol 2001; 280: R1564-72
15. Fox SB. Assessing tumor angiogenesis in histological samples. Methods Mol Biol 2009; 467: 55-78
16. Staton CA, Chetwood AS, Cameron IC, Cross SS, Brown NJ, Reed MW. The angiogenic switch occurs at the adenoma stage of the adenoma carcinoma sequence in colorectal cancer. Gut 2007; 56: 1426-1432
17. Ando H, Takamura T, Ota T, Nagai Y, Kobayashi K. Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. J Pharmacol Exp Ther 2000; 294: 1043-1046
18. Guerard P, Rakotoniaina Z, Goirand F, et al. The HMG-CoA reductase inhibitor, pravastatin, prevents the development of monocrotaline-induced pulmonary hypertension in the rat though reduction of endothelial cell apoptosis and overexpression of NOSII. Naunyn Schmiedebergs Arch Pharmacol 2006; 373: 401-414
19. Harris MB, Blackstone MA, Sood SG, et al. Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors. Am J Physiol Heart Circ Physiol 2004; 287: H560-6
20. Fujii T, Onimaru M, Yonemitsu Y, Kuwano H, Sueishi K. Statins restore ischemic limb blood flow in diabetic microangiopathy via NOSII/NO upregulation but not via PDGF-BB expression. Am J Physiol Heart Circ Physiol 2008; 294: H2785-91
21. Doursout MF, Oguchi T, Fischer UM, et al. Distribution of NOS isoforms in a porcine endotoxin shock model. Shock 2008; 29: 692-702
22. Scott JA, Mehta S, Duggan M, Bihari A, McCormack DG. Functional inhibition of constitutive nitric oxide synthase in a rat model of sepsis. Am J Respir Crit Care Med 2002; 165: 1426-1432
23. Laufs U, Endres M, Custodis F, et al. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation 2000; 102: 3104-3110
24. Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998; 97: 1129-1135
25. Laufs U, Gertz K, Dirnagl U, Böhm M, Nickenig G, Endres M. Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res 2002; 942: 23-30
26. Yemisci M, Ay H, Kocaefe C, et al. Statin potentiates human platelet NOSII activity without enhancing NOSII mRNA and protein levels. Cerebrovasc Dis 2008; 26: 190-198
27. Kao SJ, Chen HI. Nitric oxide mediates acute lung injury caused by fat embolism in isolated rat's lungs. J Trauma 2008; 64: 462-469
28. Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007; 87: 315-424
29. Binion DG, Fu S, Ramanujam KS, et al. iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Am J Physiol 1998; 275: G592-603
30. Hickey MJ, Sharkey KA, Sihota EG. Inducible nitric oxide synthase-deficient mice have enhanced leucocyte-endothelium interactions in endotoxemia. FASEB J 1997; 11: 955-964
31. Hollenberg SM, Guglielmi M, Parrillo JE. Discordance between microvascular permeability and leucocyte dynamics in septic inducible nitric oxide synthase deficient mice. Crit Care 2007; 11: R125
32. Wu F, Tyml K, Wilson JX. NOSIII expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells. J Cell Physiol 2008; 217: 207-214
33. Alvarez de Sotomayor M, Vega S, Mingorance C, Marhuenda E, Herrera MD. Effects of HMG-CoA reductase inhibition by simvastatin on vascular dysfunction induced by lipopolysaccharide in rats. Pharmacology 2008; 82: 89-96
34. Madonna R, Di Napoli P, Massaro M, et al. Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. J Biol Chem 2005; 280: 13503-13511
35. Huang KC, Chen CW, Chen JC, Lin WW. HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages. J Biomed Sci 2003; 10: 396-405
36. Merx MW, Liehn EA, Janssens U, et al. HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis. Circulation 2004; 109: 2560-2565