Pharmacology of ginsenosides

Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes

Volumn , Issue , 2013, Pages 3497-3514

  Leung, Kar Wah ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Ginseng; Ginsenosides; Steroidal hormone receptors

Indexed keywords

EID: 84939296269     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-22144-6_151     Document Type: Chapter

References (116)

1. Bigelow J (1817) American Medical Botany. Boston: Cummings and Hillard
2. Sadler T (1999) Australian ginseng. Crop establishment research. Rural Industries Research and Development Corporation, Barton
3. Lim W, Mudge KW, Vermeylen F (2005) Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium). J Agric Food Chem 53:8498-8505
4. Schlag EM, Mclntosh MS (2006) Ginsenoside content and variation among and within American ginseng (Panax quinquefolius L.) populations. Phytochemistry 67:1510-1519
5. Kim WY, Kim JM, Han SB, Lee SK, Kim ND, Park MK, Kim CK, Park JH (2000) Steaming of ginseng at high temperature enhances biological activity. J Nat Prod 63:1702-1704
6. Kasai R, Besso H, Tanaka O, Saruwatari Y, Fuwa T (1983) Saponins of red ginseng. Chem Pharm Bull(Tokyo) 31:2120-2125
7. Kim SI, Park JH, Ryu JH, Park JD, Lee YH, Park JH, Kim TH, Baek NI (1996) Ginsenoside Rg5, a genuine dammarane glycoside from Korean red ginseng. Arch Pharm Res 19:551-553
8. Ryu JH, Park JH, Eun JH, Jung JH, Sohn DH (1997) A dammarane glycoside from Korean red ginseng. Phytochemistry 44:931-933
9. Park JD, Lee YH, Kim SI (1998) Ginsenoside Rf2, a new dammarane glycoside from Korean red ginseng (Panax ginseng). Arch Pharm Res 21:615-617
10. Kaneko H, Nakanishi K (2004) Proof of the mysterious efficacy of ginseng: basic effects of medical ginseng, Korean red ginseng: its anti-stress action for prevention of disease. J Pharmacol Sci 95:158-162
11. Lee KY, Lee YH, Kim SI, Park JH, Lee SK (1997) Ginsenoside-Rg5 suppresses cyclin E-dependent protein kinase activity via up-regulating p21Cip/WAF1 and down-regulating cyclin E in SK-HEP-1 cells. Anticancer Res 17:1067-1072
12. Liu WK, Xu SX, Che CT (2000) Anti-proliferative effect of ginseng saponins on human prostate cancer cell line. Life Sci 67:1297-1306
13. Kwon SW, Han SB, Park IH, Kim JM, Park MK, Park JH (2001) Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A 921:335-339
14. Xu TM, Xin Y, Cui MH, Jiang X, Gu LP (2007) Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer. Chin Med J (Engl) 120:584-588
15. Kim YJ, Kwon HC, Ko H, Park JH, Kim HY, Yoo JH, Yang HO (2008) Anti-tumor activity of the ginsenoside Rk1 in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis. Biol Pharm Bull 31:826-830
16. Yoo JH, Kwon HC, Kim YJ, Park JH, Yang HO (2010) KG-135, enriched with selected ginsenosides, inhibits the proliferation of human prostate cancer cells in culture and inhibits xenograft growth in athymic mice. Cancer Lett 289:99-110
17. Park JH, Cha HY, Seo JJ, Hong JT, Han K, Oh KW (2005) Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. Prog Neuropsychopharmacol Biol Psychiatry 29:895-900
18. National Institutes of Health, National Center for Complementary and Alternative Medicine (NCCAM), http://nccam.nih.gov/health/asianginseng/
19. European Federation for Complementary and Alternative Medicine (EFCAM), http://www.efcam.eu/
20. Ovodov YS, Solov’eva TF (1966) Polysaccharides of Panax ginseng. Chem Nat Comp 2:292-303
21. Tomoda M, Takeda K, Shimizu N, Gonda R, Ohara N, Takada K, Hirabayashi K (1993) Characterization of two acidic polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull 16:22-25
22. Baek SH, Lee JG, Park SY, Bae ON, Kim DH, Park JH (2010) Pectic polysaccharides from Panax ginseng as the antirotavirus principals in ginseng. Biomacromolecules 11:2044-2052
23. Zhao H, Zhang W, Xiao C, Lu C, Xu S, He X, Li X, Chen S, Yang D, Chan AS, Lu A (2011) Effect of ginseng polysaccharide on TNF-a and IFN-g produced by enteric mucosal lympocytes in collagen induced arthritic rats. J Med Plant Res 5:1536-1542
24. Ivanova T, Han Y, Son HJ, Yun YS, Song JY (2006) Antimutagenic effect of polysaccharide ginsan extracted from Panax ginseng. Food Chem Toxicol 44:517-521
25. Kim HJ, Kim MH, Byon YY, Park JW, Jee Y, Joo HG (2007) Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells. J Vet Sci 8:39-44
26. Qian ZM, Lu J, Gao QP, Li SP (2009) Rapid method for simultaneous determination of flavonoid, saponins, and polyacetylenes in folium ginseng and radix ginseng by pressurized liquid extraction and high-performance liquid chromatography coupled with diode array detection and mass spectrometry. J Chromatogr A 1216:3825-3830
27. Jung CH, Seog HM, Choi IW, Cho HY (2005) Antioxidant activities of cultivated and wild Korean ginseng leaves. Food Chem 92:535-540
28. Attele AS, Wu JA, Yuan CS (1999) Multiple pharmacological effects of ginseng. Biochem Pharmacol 58:1685-1693
29. Soldati F, Tanaka O (1984) Panax ginseng: relation between age of plant and content of ginsenosides. Planta Med 50:351-352
30. Court WA, Reynolds LB, Hendel JG (1996) Influence of root age on the concentration of ginsenosides of American ginseng (Panax quinquefolium). Can J Plant Sci 76:853-855
31. Christensen LP (2009) Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 55:1-99
32. Shibata S, Fujita M, Itokawa H, Tanako O, Ishii T (1963) Studies on the constituents of Japanese and Chinese Crude Drugs. XI. Panaxadiol, a sapogenin of ginseng roots. (1). Chem Pharm Bull (Tokyo) 11:759-761
33. Matsuura H, Kasai R, Tanaka O, Saruwatari Y, Kunihiro K, Fuwa T (1984) Further studies on the dammarane-saponins of ginseng roots. Chem Pharm Bull(Tokyo) 32:1188-1192
34. Li W, Gu C, Zhang H, Awang DVC, Fitzloff JF, Fong HHS, van Breemen RB (2000) Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C.A. meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Anal Chem 72:5417-5422
35. Assinewe VA, Baum BR, Gagnon D, Arnason JT (2003) Phytochemistry of wild populations of Panax quinquefolium L. (North American ginseng). J Agric Food Chem 51:4549-4553
36. Hwang IG, Kim HY, Joung EM, Woo KS, Jeong JH, Yu KW, Lee J, Jeong HS (2010) Changes in ginsenosides and antioxidant activity of Korean ginseng (Panax ginseng C.A. Meyer) with heating temperature and pressure. Food Sci Biotechnol 19:941-949
37. Casanova H, Ortiz C, Pelaez C, Vallejo A, Moreno ME, Acevedo M (2002) Insecticide formulations based on nicotine oleate stabilized by sodium caseinate. J Agric Food Chem 50:6389-6394
38. Fukami H, Nakajima M (1971) Rotenone and rotenoids. In: Jacobson M, Crosby DG (eds) Naturally occurring insecticides. Marcel Dekker, New York, p 71
39. Elliott M (1976) Properties and applications of pyrethroids. Environ Health Perspect 14:1-13
40. Aerts RJ, Mordue AJ (1997) Feeding deterrence and toxicity of neem triterpenoids. J Chem Ecol 23:2117-2132
41. Creelman RA, Mullet JE (1997) Biosynthesis and action of jasmonates in plants. Annu Rev Plant Physiol Plant Mol Biol 48:355-381
42. Palazon J, Cusido RM, Bonfill M, Mallol A, Moyano E, Morales C, Pinol MT (2003) Elicitation of different Panax ginseng transformed root phenotypes for an improved ginsenoside production. Plant Physiol Biochem 41:1019-1025
43. Choi DW, Jung JD, Ha YI, Park HW, In DS, Chung HJ, Liu JR (2005) Analysis of transcripts in methyl jasmonate-treated ginseng hairy roots to identify genes involved in the biosynthesis of ginsenosides and other secondary metabolites. Plant Cell Rep 23:557-566
44. Ali MB, Yu KW, Hahn EJ, Paek KY (2006) Methyl jasmonate and salicylic acid elicitation induces ginsenosides accumulation, enzymatic and non-enzymatic antioxidant in suspension culture Panax ginseng roots in bioreactors. Plant Cell Rep 25:613-620
45. Nicol RW, Traquair JA, Bernards MA (2002) Ginsenosides as host resistance factors in American ginseng (Panax quinquefolius). Can J Bot 80:557-562
46. Bernards MA, Yousef LF, Nicol RW (2006) The allelopathic potential of ginsenosides. Allelochemicals: biological control of plant pathogens and diseases. Disease Management of Fruits and Vegetables 2:157-175
47. Sung WS, Lee DG (2008) In vitro candidacidal action of Korean red ginseng saponins against candida albicans. Biol Pharm Bull 31:139-143
48. Mallvadhani UV, Mahapatra A, Raja SS, Manjula C (2003) Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues. J Agric Food Chem 51:1952-1955
49. Harada T, Nakagawa Y, Akamatsu M, Miyagawa H (2009) Evaluation of hydrogen bonds of ecdysteroids in the ligand-receptor interactions using a protein modeling system. Bioorg Med Chem 17:5868-5873
50. Cutler SJ, Cutler HG (2000) Biologically active natural products: pharmaceuticals. CRC Press, New York
51. Hall T, Lu ZZ, Yat PN, Fitzloff JF, Arnason JT, Awang DVC, Fong HHS, Blumenthal M (2001) Evaluation of consistency of standardized Asian ginseng products in the ginseng evaluation program. Herbalgram 52:31-45
52. Chang TKH, Chen J, Benetton SA (2002) In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2 and CYP1B1. Drug Metab Dispos 30:378-384
53. Park SA, Kim EH, Na HK, Surh YJ (2007) KG-135 inhibits COX-2 expression by blocking the activation of JNK and AP-1 in phorbol ester-stimulated human breast epithelial cells. Ann N Y Acad Sci 1095:545-553
54. Tanaka H, Fukuda N, Shoyama Y (1999) Formation of monoclonal antibody against a major ginseng component, ginsenoside Rb1 and its characterization. Cytotechnology 29:115-120
55. Fukuda N, Tanaka H, Shoyama Y (2000) Formation of monoclonal antibody against a major ginseng component, ginsenoside Rg1 and its characterization. Cytotechnology 34:197-204
56. Morinaga O, Tanaka H, Shoyama Y (2006) Detection and quantification of ginsenoside Re in ginseng samples by chromatographic immunostaining method using monoclonal antibody against ginsenoside Re. J Chromatogr B 830:100-104
57. Joo EJ, Ha YW, Shin H, Son SH, Kim YS (2009) Generation and characterization of monoclonal antibody to ginsenoside Rg3. Biol Pharm Bull 32:548-552
58. Karikura M, Miyase T, Tanizawa H, Takino Y (1991) Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats. Chem Pharm Bull (Tokyo) 39:400-404.
59. Hasegawa H, Sung JH, Matsumiya S, Uchiyama M (1996) Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 62:453-457
60. Bae EA, Choo MK, Park EK, Park SY, Shin HY, Kim DH (2002) Metabolism of ginsenoside Re by human intestinal bacteria and its related antiollergic activity. Biol Pharm Bull 25:743-747
61. Park CS, Yoo MH, Noh KH, Oh DK (2010) Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases. Appl Microbiol Biotechnol 87:9-19
62. Popovich DG, Kitts DD (2002) Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch Biochem Biophys 406:1-8
63. Bae EA, Han MJ, Kim EJ, Kim DH (2004) Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Arch Pharm Res 27:61-67
64. Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC, Yang L (2006) Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci 91:356-364
65. Wakabayashi C, Hasegawa H, Marata J, Saiki I (1997) In vivo antimetastatic action of Ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res 9:411-417
66. Takino Y (1994) Studies on pharmacodynamics of ginsenoside-Rg1, Rb1 and-Rb2 in rats. Yakugaku Zasshi 114:550-564
67. Xu QF, Fang XL, Chen DF (2003) Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J Ethnopharmacol 84:187-192
68. Han M, Fang XL (2006) Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models. Acta Pharmacol Sin 27:499-505
69. Han M, Sha X, Wu Y, Fang X (2006) Oral absorption of ginsenoside Rb1 using in vitro and in vivo models. Planta Med 72:398-404
70. Odani T, Tanizawa H, Takino Y (1983) Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II. The absorption, distribution and excretion of ginsenoside Rg1 in the rat. Chem Pharm Bull (Tokyo) 31:292-298.
71. Odani T, Tanizawa H, Takino Y (1983) Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. III. The bsorption, distribution and excretion of ginsenoside Rb1 in the rat. Chem Pharm Bull (Tokyo) 31:1059-1066.
72. Xie HT, Wang GJ, Chen M, Jiang XL, Li H, Lv H, Huang CR, Wang R, Roberts M (2005) Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells. Biol Pharm Bull 28:383-386
73. Xiong J, Sun M, Guo J, Huang L, Wang S, Meng B, Ping Q (2009) Active absorption of ginsenoside Rg1 in vitro and in vivo: the role of odiumdependent glucose co-transporter 1. J Pharm Pharmacol 61:381-386
74. Xiong J, Sun M, Guo J, Huang L, Wang S, Meng B, Ping Q (2009) Enhancement by adrenaline of ginsenoside Rg1 transport in Caco-2 cells and oral absorption in rats. J Pharm Pharmacol 61:347-352
75. Xiong J, Guo J, Huang L, Meng B, Ping Q (2008) The use of lipid-based formulations to increase the oral bioavailability of Panax notoginseng saponins following a single oral gavage to rats. Drug Dev Ind Pharm 34:65-72
76. Han M, Fu S, Gao JQ, Fang XL (2009) Evaluation of intestinal absorption of ginsenoside Rg1 incorporated in microemulsion using parallel artificial membrane permeability assay. Biol Pharm Bull 32:1069-1074
77. Gu Y, Wang GJ, Sun JG, Jia YW, Wang W, Xu MJ, Lv T, Zheng YT, Sai Y (2009) Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs. Food Chem Toxicol 47:2257-2268
78. Xie HT, Wang GJ, Chen M, Jiang XL, Li H, Lv H, Huang CR, Wang R, Roberts M (2005) Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells. Biol Pharm Bull 28:383-386
79. Liu H, Yang J, Du F, Gao X, Ma X, Huang Y, Xu F, Niu F, Mao Y, Sun Y, Lu T, Liu C, Zhang B, Li C (2009) Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats. Drug Metab Dispos 37:2290-2298
80. Leung KW, Cheng YK, Mak NK, Chan KKC, Fan TPD, Wong RNS (2006) Signaling pathway of ginsenoside-Rgl leading to nitric oxide production in endothelial cells. FEBS Lett 580:3211-3216
81. Leung KW, Ng HM, Tang MKS, Wong CCK, Wong RNS, Wong AST (2011) Ginsenoside-Rgl mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1a to promote angiogenesis. Angiogenesis 14:515-522
82. Leung KW, Cheung LWT, Pon YL, Wong RNS, Mak NK, Fan TPD, Au SCL, Tombran-Tink J, Wong AST (2007) Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen b-receptor. Brit J Pharmacol 152:207-215
83. Suh SO, Kroh M, Kim NR, Joh YG, Cho MY (2002) Effects of red ginseng upon postoperative immunity and survival in patients with Stage III gastric cancer. Am J Chin Med 30:482-494
84. Yun TK, Choi SY (1998) Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int J Epidemiol 27:359-364
85. Yun TK, Choi SY (1990) A case-control study of ginseng intake and cancer. Int J Epidemol 19:871-6
86. He BC, Gao JL, Luo X, Luo J, Shen J, Wang L, Zhou Q, Wang YT, Luu HH, Haydon RC, Wang CZ, Du W, Yuan CS, He TC, Zhang BQ (2011) Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/b-catenin signaling. Int J Oncol 38:437-445
87. Ng WY, Yang MS (2008) Effects of ginsenosides Re and Rg3 on intracellular redox state and cell proliferation in C6 glioma cells. Chin Med 3:8
88. Kim SW, Kwon HY, Chi DW, Shim JH, Park JD, Lee YH, Pyo S, Rhee DK (2003) Reversal of p-glycoprotein-mediated multidrug resistance by ginsenosides Rg(3). Biochem Pharmacol 65:75-82
89. Zhang J, Zhou F, Wu X, Gu Y, Ai H, Zheng Y, Li Y, Zhang X, Hao G, Sun J, Peng Y, Wang G (2010) 20(S)-ginsenoside Rh2 Noncompetitively inhibits p-glycoprotein in vitro and in vivo: a case for herb-drug interaction. Drugs Metab Dispos 38:2179-2187
90. Zhang J, Zhou F, Niu F, Lu M, Wu X, Sun J, Wang G (2012) Stereoselective regulation of p-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics. PLoS One 7:e35768
91. Kemper EM, Verheij M, Boogerd W, Beijnen JH, van Tellingen O (2004) Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein. Eur J Cancer 40:1269-1274
92. van Waterschoot RA, Schinkel AH (2011) A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: recent insights from knockout and transgenic mice. Pharmacol Rev 63:390-410
93. Kimura I, Nakashima N, Sugihara Y, Fu-Jun C, Kimura M (1999) The antihyperglycemic blend effect of traditional Chinese medicine Byakko-ka-ninjin-to on alloxan and diabetic KK-CAy mice. Phytother Res 13:484-488
94. Bensky D, Gamble A (1993) Chinese herbal medicine material medica. Eastland Press, Dealttle, WA
95. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS (2002) Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51:1851-1858
96. Vuksan V, Sievenpiper JL, Koo VY, Trancis T, Beljan-Zdrankovic U, Xu Z, Vidgen E (2000) American ginseng (Panax quinquefolius L.) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 160:1009-1013
97. Akagawa G, Abe S, Tansho S, Uchida K, Yamaguchi H (1996) Protection of C3H/HEJ mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, Ginseng radix: possible roles of macrophages in the host defense mechanisms. Immunopharmacol Immunotoxicol 18:73-89
98. Lee YS, Chung IS, Lee IR, Kim KH, Hong WS, Yun YS (1997) Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsang isolated from Panax ginseng. Anticancer Res 17:323-331
99. Luo YM, Cheng XJ, Yuan WX (1993) Effects of ginseng root saponins and ginsenoside Rb1 on immunity in cold water swim stress mice and rats. Acta Pharmacol Sin 14:401-404
100. Kim JY, Germolec DR, Luster MI (1990) Panax ginseng as a potential immunomodulator: studies in mice. Immunopharmacol Immunotoxicol 12:257-276
101. Jie YH, Cammisuli S, Baggiolini M (1984) Immunomodulatory effects of Panax ginseng C.A. Meyer in the mouse. Agents Actions 15:386-391
102. Scaglione F, Ferrara F, Dugnani S, Falchi M, Santoro G, Fraschini F (1990) Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer. Drugs Exp Clin Res 16:537-542
103. Mizuno M, Yamada J, Terai H, Kozukue N, Lee YS, Tsuchida H (1994) Differences in immunomodulating effects between wild and cultured Panax ginseng. Biochem Biophys Res Commun 200:1672-1678
104. Harris J, Sengar D, Stewart T, Hyslop D (1976) The effect of immunosuppressive chemotherapy on immune function in patients with malignant disease. Cancer 37:1058-1069 Supplement: Conference on the delayed consequences of cancer therapy: proven and potential
105. Rabinovich GA, Gabrilovich D, Sotomayor EM (2007) Immunosuppressive Strategies that are mediated by tumor cells. Annu Rev Immunol 25:267-296
106. Lee YJ, Chung E, Lee KY, Lee YH, Huh B, Lee SK (1997) Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol Cell Endocrinol 133:135-140
107. Leung KW, Cheng YK, Mak NK, Chan KKC, Fan TPD, Wong RNS (2006) Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett 580:3211-3216
108. Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S (2003) A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol 84:463-468
109. Gao QG, Chen WF, Xie JX, Wong MS (2009) Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. J Neurochem 109:1338-1347
110. Furukawa T, Bai CX, Kaihara A, Ozaki E, Kawano T, Nakaya Y, Awais M, Sato M, Umezawa Y, Kurokawa J (2006) Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. Mol Pharmacol 70:1916-1924
111. Leung KW, Leung FP, Mak NK, Tombran-Tink J, Huang Y, Wong RNS (2009) Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol 156:626-637
112. Wiklung IK, Mattsson LA, Lindgren R, Limoni C (1999) Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial Swedish Alternative Medicine Group. Int J Clin Pharm Res 19:89-99
113. Salim KN, McEwen BS, Chao HM (1997) Ginsenoside Rb1 regulates ChAT, NGF and TrkA mRNA expression in the rat brain. Mol Brain Res 47:177-182. 92.
114. Choi S, Lee JH, Oh S, Rhim H, Lee SM, Nah SY (2003) Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. Mol Cells 15:108-113
115. Kim HS, Hwang SL, Oh S (2000) Ginsenoside Rc and Rg1 differentially modulate NMDA receptor subunit mRNA levels after intracerebroventricular infusion in rats. Neurochem Res 25:1149-1154
116. Choi S, Jung SY, Lee JH, Sala F, Criado M, Mulet J, Valor LM, Sala S, Engel AG, Nah SY (2002) Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur J Pharmacol 442:37-45