Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Zhang, Jingwei ^a   Zhou, Fang ^a   Niu, Fang ^a   Lu, Meng ^a   Wu, Xiaolan ^a   Sun, Jianguo ^a   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; DOXORUBICIN; GINSENOSIDE RH 2; GLYCOPROTEIN P; PROTOPANAXADIOL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DEGLYCOSYLATION; DOSE RESPONSE; DRUG ABSORPTION; DRUG DOSE INCREASE; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TRANSFORMATION; EPIMER; FECES MICROFLORA; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; DIGOXIN; GINSENOSIDES; GLYCOSYLATION; HUMANS; INHIBITORY CONCENTRATION 50; INTESTINES; MALE; METAGENOME; P-GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 84860014033     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035768     Document Type: Article

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