Enhancement by adrenaline of ginsenoside Rg1 transport in Caco-2 cells and oral absorption in rats

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 3, 2009, Pages 347-352

  Xiong, Jing ^a   Sun, Minjie ^a   Guo, Jianxin ^b   Huang, Luosheng ^a   Wang, Shujing ^a   Meng, Boyu ^a   Ping, Qineng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Talecris Biotherapeutics Inc   (United States)

Author keywords

Absorption enhancer; Adrenaline (epinephrine); Caco 2 cells; Ginsenoside Rg1; Oral bio availability

Indexed keywords

ADRENALIN; BETA 2 ADRENERGIC RECEPTOR; GINSENOSIDE RG 1; ISOPRENALINE; PHENTOLAMINE; PROPRANOLOL; SALBUTAMOL; ADRENERGIC RECEPTOR BLOCKING AGENT; ADRENERGIC RECEPTOR STIMULATING AGENT; CENTRAL NERVOUS SYSTEM AGENTS; GINSENOSIDE;

ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE TRANSPORT; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; NONHUMAN; RAT; ANIMAL; AREA UNDER THE CURVE; BIOAVAILABILITY; DOSE RESPONSE; DRUG POTENTIATION; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, ORAL; ADRENERGIC AGONISTS; ADRENERGIC ANTAGONISTS; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CENTRAL NERVOUS SYSTEM AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; GINSENOSIDES; HUMANS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; TIME FACTORS;

EID: 85047681259     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.03.0009     Document Type: Article

References (33)

1. Tsang et al. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med 1985; 51: 221-224.
2. Kenaroba B et al. Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn J Pharmacol 1990; 54: 447-454.
3. Li X et al. Protective effects of Panax notoginseng saponins on experimental myocardial injury induced by ischemia and reperfusion in rat. Acta Pharmacol Sin 1990; 11: 26-29.
4. Yamaguchi Y et al. Effects of ginsenosides on impaired on performance induced in the rat by scopolamine in a radial-arm maze. Psychoneuroendocrinology 1995; 20: 645-653.
5. Lee YJ et al. Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol Cell Endocrinol 1997; 133: 135-140.
6. Lee EJ et al. Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation. Int Immuno-pharmacol 2004; 4: 235-244.
7. Radad K et al. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res 2004; 1021: 41-53.
8. Odani T et al. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. III. The absorption, distribution and excretion of ginsenoside Rg1 in the rat. Chem Pharm Bull 1983; 31: 292-298.
9. Kanaoks M et al. Metabolism of ginseng saponins, ginsenoside, by human intestinal flora. Wakan Ryakugaku Zasshi 1994; 11: 241-246.
10. Hasegawa H et al. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 1996; 62: 453-457.
11. Han M, Fang XL. Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models. Acta Pharmacol Sin 2006; 27: 499-505.
12. Xiong J et al. Self-micelle formation and the incorporation of lipid in the formulation affect the intestinal absorption of Panax notoginseng. Int J Pharm 2008; 360: 191-196.
13. Swenson ES, Curatolo WJ. Means to enhance penetration intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity. Adv Drug Deliv Rev 1992; 8: 39-92.
14. Lee VHL. Protease inhibitors and penetration enhancers as approaches to modify peptide absorption. J Control Release 1990; 13: 213-223.
15. Yamamoto A et al. Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane. J Pharm Sci 1996; 48: 1285-1289.
16. Numata N et al. Improvement of intestinal absorption of macromolecules by nitric oxide donor. J Pharm Sci 2000; 89: 1296-1304.
17. Utoguchi N et al. Nitric oxide donor enhances rectal absorption of macromolecules in rabbits. Pharm Res 1998; 15: 870-876.
18. Watanabe Y et al. Absorption enhancement of a protein drug by nitric oxide donor: effect on nasal absorption of human granulocyte colony-stimulating factor. J Drug Target 2000; 8: 185-194.
19. Skowronski MT et al. Enhancement by epinephrine of benzylpenicillin transport in rat small intestine. J Pharmacol Exp Ther 2000; 293: 128-135.
20. Kamio Y et al. Epinephrine is an enhancer of rat intestinal absorption. J Control Release 2005; 102: 563-568.
21. Artursson P, Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 1991; 175: 880-885.
22. Artursson P et al. Caco-2 monolayers in experimental and theoretical prediction of drug transport. Adv Drug Deliv Rev 2001; 46: 27-43.
23. Meunier V et al. The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications. Cell Biol Toxicol 1995; 11: 187-194.
24. Hidalgo IJ, Li J. Carrier-mediated transport and efflux mechanisms in Caco-2 cells. Adv Drug Deliv Rev 1996; 22: 53-66.
25. Mossman TJ. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
26. Tada H et al. An improved colorimetric assay for interleukin 2. J Immunol Methods 1986; 92: 157-165.
27. Gu HH et al. Cell-specific sorting of biogenic amine transporters expressed in epithelial cells. J Biol Chem 1996; 271: 18 100-18 106.
28. Hirdebrand KR, Brown DR. Norepinephrine and alpha-2 adrenoceptors modulate active ion transport in porcine small intestine. J Pharmacol Exp Ther 1992; 263: 510-519.
29. Paris H et al. Alpha-2 adrenoceptor in rat jejunum epithelial cells: characterization with [3H]RX821002 and distribution along the villus-crypt axis. J Pharmacol Exp Ther 1990; 254: 888-893.
30. Ishikawa Y et al. Mechanism of β-adrenergic agonist induced transmural transport of glucose in rat small intestine: regulation of phosphorylation of SGLT 1 controls the function. Biochim Biophys Acta 1997; 1357: 306-318.
31. + exchange in neuroblastoma X glioma cells. J Biol Chem 1987; 262: 6750-6757.
32. i-Dependent phosphorylation of the Na-K-Cl cotransport protein of dog tracheal epithelial cells. J Biol Chem 1995; 270: 28 955-28 961.
33. Feldman RD. β-Adrenergic inhibition of Na-K-Cl cotransport in lymphocytes. Am J Physiol 1992; 263: C1015-C1020.