Ibuprofen: Effect on inducible nitric oxide synthase

Molecular Brain Research

Volumn 50, Issue 1-2, 1997, Pages 107-112

  Stratman, Nancy C ^a   Carter, Donald B ^a   Sethy, Vimala H ^a  

^a PFIZER INC   (United States)

Author keywords

Cultures; Glia; Ibuprofen; iNOS; Neurodegenerative disorder

Indexed keywords

CYTOCHROME C OXIDASE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; IBUPROFEN; MESSENGER RNA; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GENETIC TRANSCRIPTION; GLIA CELL; IMMUNOBLOTTING; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; RNA PROCESSING; SIDE EFFECT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; ENZYME INDUCTION; IBUPROFEN; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

ANIMALIA; ESCHERICHIA COLI;

EID: 0030669260     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00168-X     Document Type: Article

References (17)

1. E.E. Aeberhard, S.A. Henderson, N.S. Arabolow, J.M. Griscavage, F.E. Castro, C.T. Barrett, L.J. Ignarro, Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene, Biochem. Biophys. Res. Commun. 208 (1995) 1053-1059.
2. K. Anderson, L. J. Launer, A. Ott, A.W. Hoes, M.M.B. Bretelr, A. Hofman, Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam study, Neurology 45 (1995) 1441-1445.
3. J.C.S. Breitner, K.A. Welsh, M.J. Helms, P.C. Gaskell, B.A. Gau, A.D. Roses, M.A. Pericak-Vance, A M. Saunders, Inverse association of anti-inflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study, Neurobiol. Aging 16 (1995) 523-530.
4. C.C. Chao, S. Hu, T.W. Molitor, E.G. Shaskan, P.K. Peterson, Activated microglia mediate neuronal cell injury via a nitric oxide mechanism, J. Immun. 149 (1992) 2736-2741.
5. P. Chomczynski, N. Sacchi, Single-step method of RNA isolation by acid-guanidinium-thicyanate-phenol-chloroform extraction, Anal. ChemV.P.. 162 (1987) 156-159.
6. T.M. Dawson, V.L. Dawson, S.H. Snyder, A novel neuronal messenger molecule in brain: The free radical, nitric oxide, Ann. Neurol. 32 (1992) 297-311.
7. L. Feng, W. Sun, Y. Xia, W.W. Tang, P. Chanmugam, E. Soyoola, C.B. Wilson, D. Hwang, Cloning two isoforms of rat cyclooxygenase: Differential regulation of their expression, Arch. Biochem. Biophys. 307 (1993) 361-368.
8. Y.G. Geng, M. Almqvist, G.K. Hansson, cDNA cloning and expression of inducible nitric oxide synthase from rat vascular smooth muscle cells, Biochim. Biophys. Acta 1218 (1994) 421-424.
9. B.P. Kennedy, C.C. Chan, S.A. Culp, W.A. Cromlish, Cloning and expression or rat prostaglandin endoperoxide synthase (cyclooxygenase-2) cDNA, Biochem. Biophys. Res. Commun. 197 (1993) 494-500.
10. E.A. Meade, W.L. Smith, D.L. DeWitt, Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme by aspirin and other non-steroidal anti-inflammatory drugs, J. Biol. Chem. 268 (1993) 6610-6614.
11. L. Minghetti, G. Levi, Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures, J. Neurochem. 65 (1995) 2690-2698.
12. J.A. Mitchell, P. Akarasereenont, C. Thiemermann, R.J. Flower, Selectivity of non-steroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxyigenase, Proc. Natl. Acad. Sci. USA 90 (1994) 11693-11697.
13. S. Moncada, E.A. Higgs, Molecular mechanisms and therapeutic strategies related to nitric oxide, FASEB J. 9 (1995) 1319-1330.
14. N.C. Stratman, G.J. Fici, V.H. Sethy, U-19451 A: A selective inducible nitric oxide synthase inhibitor, Lite Sci. 59 (1996) 945-951.
15. C. Tordjman, F. Coge, N. Andre, H. Rique, M. Spedding, J. Bonneti, Characterization of cyclooxygenase 1 and 2 expression in mouse resident peritoneal macrophages in vitro; interactions of non steroidal anti-inflammatory drugs with COX2, Biochim. Biophys. Acta 1256 (1995) 249-256.
16. J.Y. Tso, X. Sun, T. Kao, K.S. Reece, R. Wu, Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: Genomic complexity and molecular evolution of the gene, Nucleic Acids Res. 13 (1985) 2485-2502.
17. J.R. Vane, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 231 (1971) 232-235.