Shifting gear in antimicrobial and anticancer peptides biophysical studies: From vesicles to cells

Journal of Peptide Science

Volumn 21, Issue 3, 2015, Pages 178-185

  Freire, João M ^a   Gaspar, Diana ^a   Veiga, Ana Salomé ^a   Castanho, Miguel A R B ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

anticancer; antimicrobial; bacteria; biophysics; cell; lipid; membrane; peptide; spectroscopy; vesicle

Indexed keywords

ANTINEOPLASTIC AGENT; CECROPIN A; GOMISIN; LACTOFERRICIN B; LIPID; MAGAININ 2; MASTOPARAN; MELITTIN; OMIGANAN; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEGRIN; ANTIMICROBIAL CATIONIC PEPTIDE; LIPID BILAYER; LIPOSOME;

ANTIBACTERIAL ACTIVITY; ATOMIC FORCE MICROSCOPY; BACTERIAL MEMBRANE; BACTERIAL OUTER MEMBRANE; BACTERIAL STRAIN; BIOPHYSICS; CANCER CELL; CELL FUNCTION; CELL INTERACTION; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL VACUOLE; DRUG MECHANISM; FLOW CYTOMETRY; FLUORESCENCE SPECTROSCOPY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; LIGHT SCATTERING; LIPID BILAYER; NEOPLASM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REVIEW; UBIQUITINATION; ZETA POTENTIAL; CELL SURVIVAL; CHEMICAL ANALYSIS; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL VIABILITY; SPECIES DIFFERENCE; STAPHYLOCOCCUS AUREUS; TUMOR CELL LINE;

BACTERIA (MICROORGANISMS);

ANTIMICROBIAL CATIONIC PEPTIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY TECHNIQUES, ANALYTICAL; ESCHERICHIA COLI; HUMANS; LIPID BILAYERS; LIPOSOMES; MICROBIAL VIABILITY; SPECIES SPECIFICITY; STAPHYLOCOCCUS AUREUS;

EID: 84923644827     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2741     Document Type: Review

References (44)

1. Drucker P, Grill D, Gerke V, Galla HJ,. Formation and characterization of supported lipid bilayers containing phosphatidylinositol-4,5-bisphosphate and cholesterol as functional surfaces. Langmuir 2014. 10.1021/la503203a.
2. Salay LC, Procopio J, Oliveira E, Nakaie CR, Schreier S,. Ion channel-like activity of the antimicrobial peptide tritrpticin in planar lipid bilayers. FEBS Lett. 2004; 565 (1-3): 171-175. 10.1016/j.febslet.2004.03.093.
3. Melo MN, Ferre R, Castanho MARB,. Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations. Nature Rev. Microbiol. 2009; 7 (3): 245-250. 10.1038/Nrmicro2095.
4. Alves CS, Melo MN, Franquelim HG, Ferre R, Planas M, Feliu L, Bardaji E, Kowalczyk W, Andreu D, Santos NC, Fernandes MX, Castanho MARB,. Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR. J. Biol.Chem. 2010; 285 (36): 27536-27544. 10.1074/jbc.M110.130955.
5. Avitabile C, D'Andrea LD, Romanelli A,. Circular dichroism studies on the interactions of antimicrobial peptides with bacterial cells. Sci. Rep. 2014; 4 (4293): 1-7. 10.1038/srep04293.
6. Gee ML, Burton M, Grevis-James A, Hossain MA, McArthur S, Palombo EA, Wade JD, Clayton AH,. Imaging the action of antimicrobial peptides on living bacterial cells. Sci. Rep. 2013; 3 (1557): 1-6. 10.1038/srep01557.
7. Roversi D, Luca V, Aureli S, Park Y, Mangoni ML, Stella L,. How many antimicrobial peptide molecules kill a bacterium? The case of PMAP-23. ACS Chem. Biol. 2014; 9 (9): 2003-2007. 10.1021/Cb500426r.
8. Melo MN, Castanho MARB,. Omiganan interaction with bacterial membranes and cell wall models. Assigning a biological role to saturation. Biochim. Biophys. Acta 2007; 1768 (5): 1277-1290. 10.1016/j.bbamem.2007.02.005.
9. Melo MN, Dugourd D, Castanho MA,. Omiganan pentahydrochloride in the front line of clinical applications of antimicrobial peptides. Recent Pat. Antiinfect. Drug Discov. 2006; 1 (2): 201-207.
10. Torcato IM, Huang YH, Franquelim HG, Gaspar DD, Craik DJ, Castanho MARB, Henriques ST,. The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability. Chembiochem 2013; 14 (15): 2013-2022. 10.1002/cbic.201300274.
11. Domingues MM, Bianconi ML, Barbosa LR, Santiago PS, Tabak M, Castanho MA, Itri R, Santos NC,. rBPI21 interacts with negative membranes endothermically promoting the formation of rigid multilamellar structures. Biochim. Biophys. Acta 2013; 1828 (11): 2419-2427. 10.1016/j.bbamem.2013.06.009.
12. Domingues MM, Castanho MARB, Santos NC,. rBPI(21) Promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes. Plos One 2009; 4 (12): 1-8. 10.1371/Journal.Pone.0008385.
13. Domingues MM, Silva PM, Franquelim HG, Carvalho FA, Castanho MA, Santos NC,. Antimicrobial protein rBPI21-induced surface changes on Gram-negative and Gram-positive bacteria. Nanomedicine 2014; 10 (3): 543-551. 10.1016/j.nano.2013.11.002.
14. Lerche MH, Jensen PR, Karlsson M, Meier S,. NMR insights into the inner workings of living cells. Anal. Chem. 2014. 10.1021/ac501467x.
15. Pillet F, Chopinet L, Formosa C, Dague E,. Atomic force microscopy and pharmacology: from microbiology to cancerology. Biochim. Biophys. Acta 2014; 1840 (3): 1028-1050. 10.1016/j.bbagen.2013.11.019.
16. Persson F, Barkefors I, Elf J,. Single molecule methods with applications in living cells. Curr. Opin. Biotechnol. 2013; 24 (4): 737-744. 10.1016/j.copbio.2013.03.013.
17. Alves ID, Bechara C, Walrant A, Zaltsman Y, Jiao CY, Sagan S,. Relationships between membrane binding, affinity and cell internalization efficacy of a cell-penetrating peptide: penetratin as a case study. Plos One 2011; 6 (9): 1-10. 10.1371/journal.pone.0024096.
18. Melo MN, Castanho MA,. The mechanism of action of antimicrobial peptides: lipid vesicles vs. bacteria. Front. Immunol. 2012; 3 (236): 1-4. 10.3389/fimmu.2012.00236.
19. Ye J, Fox SA, Cudic M, Rezler EM, Lauer JL, Fields GB, Terentis AC,. Determination of penetratin secondary structure in live cells with Raman microscopy. J. Am. Chem. Soc. 2010; 132 (3): 980-988. 10.1021/Ja9043196.
20. Ferre R, Melo MN, Correia AD, Feliu L, Bardaji E, Planas M, Castanho M,. Synergistic effects of the membrane actions of cecropin-melittin antimicrobial hybrid peptide BP100. Biophys. J. 2009; 96 (5): 1815-1827. 10.1016/j.bpj.2008.11.053.
21. Melo MN, Ferre R, Feliu L, Bardaji E, Planas M, Castanho MARB,. Prediction of antibacterial activity from physicochemical properties of antimicrobial peptides. Plos One 2011; 6 (12): 1-6. 10.1371/journal.pone.0028549.
22. Henriques ST, Melo MN, Castanho MA,. Cell-penetrating peptides and antimicrobial peptides: how different are they? Biochem. J. 2006; 399 (1): 1-7. 10.1042/BJ20061100.
23. Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T,. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J. Lab. Clin. Med. 1993; 122 (2): 202-207.
24. Sewald N, Jakubke H-D., Peptides: Chemistry and Biology, Second, Revised and Updated ed., Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, 2009.
25. Hamman JH, Steenekamp JH,. Peptide Drug Discovery and Development, Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, 2011.
26. Freire JM, Gaspar D, de la Torre BG, Veiga AS, Andreu D, Castanho MA,. Monitoring antibacterial permeabilization in real time using time-resolved flow cytometry. Biochim. Biophys. Acta 2014; 1848 (2): 554-560. 10.1016/j.bbamem.2014.11.001.
27. Berney M, Hammes F, Bosshard F, Weilenmann HU, Egli T., Assessment and interpretation of bacterial viability by using the LIVE/DEAD BacLight kit in combination with flow cytometry. Appl. Environ. Microbiol. 2007; 73 (10): 3283-3290. 10.1128/Aem.02750-06.
28. Junkes C, Harvey RD, Bruce KD, Dolling R, Bagheri M, Dathe M,. Cyclic antimicrobial R-, W-rich peptides: the role of peptide structure and E. coli outer and inner membranes in activity and the mode of action. European Biophysics Journal with Biophys. Lett. 2011; 40 (4): 515-528. 10.1007/s00249-011-0671-x.
29. Gaspar D, Veiga AS, Castanho MA,. From antimicrobial to anticancer peptides. A review. Front. Microbiol. 2013; 4 (294): 1-16. 10.3389/fmicb.2013.00294.
30. Hoskin DW, Ramamoorthy A,. Studies on anticancer activities of antimicrobial peptides. Biochim. Biophys. Acta 2008; 1778 (2): 357-375. 10.1016/j.bbamem.2007.11.008.
31. Gaspar D, Veiga AS, Sinthuvanich C, Schneider JP, Castanho MA,. Anticancer peptide SVS-1: efficacy precedes membrane neutralization. Biochemistry 2012; 51 (32): 6263-6265. 10.1021/bi300836r.
32. Gaspar D, Freire JM, Pacheco TR, Barata JT, Castanho MA,. Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics. Biochim. Biophys. Acta 2014. 10.1016/j.bbamcr.2014.11.006.
33. Torcato IM, Huang YH, Franquelim HG, Gaspar D, Craik DJ, Castanho MA, Troeira Henriques S,. Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. Biochim. Biophys. Acta 2013; 1828 (3): 944-955. 10.1016/j.bbamem.2012.12.002.
34. Schroder-Borm H, Bakalova R, Andra J,. The NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine. FEBS Lett. 2005; 579 (27): 6128-6134. 10.1016/j.febslet.2005.09.084.
35. Eliassen LT, Berge G, Leknessund A, Wikman M, Lindin I, Lokke C, Ponthan F, Johnsen JI, Sveinbjornsson B, Kogner P, Flaegstad T, Rekdal O,. The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo. Int. J. Cancer 2006; 119 (3): 493-500. 10.1002/Ijc.21886.
36. Lin WJ, Chien YL, Pan CY, Lin TL, Chen JY, Chiu SJ, Hui CF,. Epinecidin-1, an antimicrobial peptide from fish (Epinephelus coioides) which has an antitumor effect like lytic peptides in human fibrosarcoma cells. Peptides 2009; 30 (2): 283-290. 10.1016/j.peptides.2008.10.007.
37. Wang KR, Yan JX, Zhang BZ, Song JJ, Jia PF, Wang R,. Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer Lett. 2009; 278 (1): 65-72. 10.1016/j.canlet.2008.12.027.
38. Sinthuvanich C, Veiga AS, Gupta K, Gaspar D, Blumenthal R, Schneider JP,. Anticancer beta-hairpin peptides: membrane-induced folding triggers activity. J. Am. Chem. Soc. 2012; 134 (14): 6210-6217. 10.1021/ja210569f.
39. Paredes-Gamero EJ, Martins MNC, Cappabianco FAM, Ide JS, Miranda A,. Characterization of dual effects induced by antimicrobial peptides: regulated cell death or membrane disruption. Biochim. Biophys. Acta 2012; 1820 (7): 1062-1072. 10.1016/j.bbagen.2012.02.015.
40. Kao FS, Pan YR, Hsu RQ, Chen HM,. Efficacy verification and microscopic observations of an anticancer peptide, CB1a, on single lung cancer cell. Biochim. Biophys. Acta 2012; 1818 (12): 2927-2935. 10.1016/j.bbamem.2012.07.019.
41. Li JT, Zhang JL, He H, Ma ZL, Nie ZK, Wang ZZ, Xu XG,. Apoptosis in human hepatoma HepG2 cells induced by corn peptides and its anti-tumor efficacy in H22 tumor bearing mice. Food Chem. Toxicol. 2013; 51: 297-305. 10.1016/j.fct.2012.09.038.
42. Ma J, Huang F, Lin H, Wang X,. Isolation and purification of a peptide from Bullacta exarata and its impaction of apoptosis on prostate cancer cell. Mar. Drugs 2013; 11 (1): 266-273. 10.3390/md11010266.
43. Xu H, Chen CX, Hu J, Zhou P, Zeng P, Cao CH, Lu JR,. Dual modes of antitumor action of an amphiphilic peptide A(9)K. Biomaterials 2013; 34 (11): 2731-2737. 10.1016/j.biomaterials.2012.12.039.
44. de Azevedo RA, Figueiredo CR, Ferreira AK, Matsuo AL, Massaoka MH, Girola N, Auada AV, Farias CF, Pasqualoto KF, Rodrigues CP, Barbuto JA, Levy D, Bydlowski SP, de Sa-Junior PL, Travassos LR, Lebrun I,. Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo. Peptides 2014. 10.1016/j.peptides.2014.09.024.