Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro

Oncology Reports

Volumn 34, Issue 4, 2015, Pages 1853-1874

  Chiang, I Tsang ^a,b   Wang, Wei Shu ^a   Liu, Hsin Chung ^c   Yang, Su Tso ^d   Tang, Nou Ying ^c   Chung, Jing Gung ^c,e  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; CDNA microarray; Cell cycle; Curcumin; DNA damage; NCI H460 cells

Indexed keywords

CELL CYCLE PROTEIN 6; COMPLEMENTARY DNA; CURCUMIN; CYCLIN DEPENDENT KINASE 5; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; INHIBITOR OF DIFFERENTIATION 3; OSTEOPROTEGERIN; S PHASE KINASE ASSOCIATED PROTEIN 2; TUMOR PROTEIN;

APOPTOSIS; ARHAP29 GENE; ARTICLE; BRMS1L GENE; CADM2 GENE; CARD6 GENE; CCNE2 GENE; CCPG1 GENE; CDC25A GENE; CDC5L GENE; CDC6 GENE; CDCA5 GENE; CDCA76 GENE; CDK14 GENE; CDK5 GENE; CELL CYCLE; CELL INVASION; CELL MIGRATION; CELL SURVIVAL; CGREF1 GENE; DDIT3 GENE; DDIT4 GENE; DNA DAMAGE; DNA SYNTHESIS; DOWN REGULATION; DRUG MECHANISM; GADD45A GENE; GAS5 GENE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; ID1 GENE; ID2 GENE; ID3 GENE; IN VITRO STUDY; LUNG CANCER CELL LINE; MICROARRAY ANALYSIS; NCI H460 CELL LINE; PRIORITY JOURNAL; RNA EXTRACTION; SKP2 GENE; TAKMIP2 GENE; TNFRSF10B GENE; TNFRSF11B GENE; TP53INP1 GENE; TSSC1 GENE; UPREGULATION; BIOSYNTHESIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL MOTION; DRUG EFFECTS; GENETICS; LUNG NEOPLASMS; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CURCUMIN; DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS;

EID: 84939195455     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.4159     Document Type: Article

References (37)

1. Buyukcelik A, Yalcin B and Utkan G: Multidisciplinary management of lung cancer. N Engl J Med 350: 2008-2010, 2004.
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
3. McCulloch M, See C, Shu XJ, Broffman M, Kramer A, Fan WY, Gao J, Lieb W, Shieh K and Colford JM Jr: Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer: Meta-analysis of randomized trials. J Clin Oncol 24: 419-430, 2006.
4. Tsai MF, Wang CC and Chen JJ: Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in non-small cell lung cancer. World J Clin Oncol 5: 865-873, 2014.
5. Prasad S, Tyagi AK and Aggarwal BB: Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice. Cancer Res Treat 46: 2-18, 2014.
6. Hasima N and Aggarwal BB: Cancer-linked targets modulated by curcumin. Int J Biochem Mol Biol 3: 328-351, 2012.
7. Campbell FC and Collett GP: Chemopreventive properties of curcumin. Future Oncol 1: 405-414, 2005.
8. Sarkar FH and Li Y: Cell signaling pathways altered by natural chemopreventive agents. Mutat Res 555: 53-64, 2004.
9. Shishodia S, Sethi G and Aggarwal BB: Curcumin: Getting back to the roots. Ann NY Acad Sci 1056: 206-217, 2005.
10. Zanotto-Filho A, Braganhol E, Edelweiss MI, Behr GA, Zanin R, Schröder R, Simões-Pires A, Battastini AM and Moreira JC: The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma. J Nutr Biochem 23: 591-601, 2012.
11. Xiao K, Jiang J, Guan C, Dong C, Wang G, Bai L, Sun J, Hu C and Bai C: Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells. J Pharmacol Sci 123: 102-109, 2013.
12. Chen QY, Zheng Y, Jiao DM, Chen FY, Hu HZ, Wu YQ, Song J, Yan J, Wu LJ and Lv GY: Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway. J Nutr Biochem 25: 177-185, 2014.
13. Lev-Ari S, Starr A, Katzburg S, Berkovich L, Rimmon A, Ben-Yosef R, Vexler A, Ron I and Earon G: Curcumin induces apoptosis and inhibits growth of orthotopic human non-small cell lung cancer xenografts. J Nutr Biochem 25: 843-850, 2014.
14. Shen Y, Zhang S, Huang X, Chen K, Shen J and Wang Z: Involvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cells. Biomed Res Int 2014: 920275, 2014.
15. Muller PA and Vousden KH: p53 mutations in cancer. Nat Cell Biol 15: 2-8, 2013.
16. Bunn PA Jr: Worldwide overview of the current status of lung cancer diagnosis and treatment. Arch Pathol Lab Med 136: 1478-1481, 2012.
17. Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, Ince WL, Jänne PA, Januario T, Johnson DH, et al: Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with nonsmall-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23: 5900-5909, 2005.
18. Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SH, Dezube BJ, Jänne PA, Costa DB, et al: Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 363: 1693-1703, 2010.
19. Wu SH, Hsiao YT, Chen JC, Lin JH, Hsu SC, Hsia TC, Yang ST, Hsu WH and Chung JG: Bufalin alters gene expressions associated DNA damage, cell cycle, and apoptosis in human lung cancer NCI-H460 cells in vitro. Molecules 19: 6047-6057, 2014.
20. Gardina PJ, Clark TA, Shimada B, Staples MK, Yang Q, Veitch J, Schweitzer A, Awad T, Sugnet C, Dee S, et al: Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array. BMC Genomics 7: 325, 2006.
21. Li Z, Meng Q, Yu Q, Zhou Z and Li L: Evaluation of c-myc and CCNE2 amplification in breast cancer with quantitative multigene fluorescence in-situ hybridization. Zhonghua Bing Li Xue Za Zhi 43: 455-458, 2014 (In Chinese).
22. Kawase T, Ichikawa H, Ohta T, Nozaki N, Tashiro F, Ohki R and Taya Y: p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis. Oncogene 27: 3797-3810, 2008.
23. Shahbazi J, Lock R and Liu T: Tumor protein 53-induced nuclear protein 1 enhances p53 function and represses tumorigenesis. Front Genet 4: 80, 2013.
24. Kim GS, Kang J, Bang SW and Hwang DS: Cdc6 localizes to S-and G2-phase centrosomes in a cell cycle-dependent manner. Biochem Biophys Res Commun 456: 763-767, 2015.
25. Bidkhori G, Narimani Z, Hosseini Ashtiani S, Moeini A, Nowzari-Dalini A and Masoudi-Nejad A: Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma. PLoS One 8: e67552, 2013.
26. Davidson G and Niehrs C: Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol 20: 453-460, 2010.
27. Ding Y, Zhu W, Sun R, Yuan G, Zhang D, Fan Y and Sun J: Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells. Oncol Rep 33: 1434-1442, 2015.
28. Jiang DS, Wei X, Zhang XF, Liu Y, Zhang Y, Chen K, Gao L, Zhou H, Zhu XH, Liu PP, et al: IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling. Nat Commun 5: 3303, 2014.
29. Li L, Chen W, Zhu Y, Wang X, Jiang DS, Huang F, Wang L, Xiang F, Qin W, Wang Q, et al: Caspase recruitment domain 6 protects against cardiac hypertrophy in response to pressure overload. Hypertension 64: 94-102, 2014.
30. Norton JD: ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 113: 3897-3905, 2000.
31. Lasorella A, Uo T and Iavarone A: Id proteins at the cross-road of development and cancer. Oncogene 20: 8326-8333, 2001.
32. Sikder HA, Devlin MK, Dunlap S, Ryu B and Alani RM: Id proteins in cell growth and tumorigenesis. Cancer Cell 3: 525-530, 2003.
33. Sun LY, Bokov AF, Richardson A and Miller RA: Hepatic response to oxidative injury in long-lived Ames dwarf mice. FASEB J 25: 398-408, 2011.
34. Martins C, Doran C, Silva IC, Miranda C, Rueff J and Rodrigues AS: Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells. Chem Biol Interact 218: 1-9, 2014.
35. Wang X, Liu Y, Shao D, Qian Z, Dong Z, Sun Y, Xing X, Cheng X, Du H, Hu Y, et al: Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer. Gastric Cancer: Jan 25, 2015 (Epub ahead of print). http://dx.doi.org/10.1007/s10120-015-0467-2.
36. Kino T, Hurt DE, Ichijo T, Nader N and Chrousos GP: Noncoding RNA gas5 is a growth arrest-and starvation-associated repressor of the glucocorticoid receptor. Sci Signal 3: ra8, 2010.
37. Mourtada-Maarabouni M, Hasan AM, Farzaneh F and Williams GT: Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript s5 (GAS5). Mol Pharmacol 78: 19-28, 2010.