Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells

Chemico-Biological Interactions

Volumn 218, Issue , 2014, Pages 1-9

  Martins, Célia ^a   Doran, Carolina ^a   Silva, Inês C ^a   Miranda, Claudia ^a   Rueff, José ^a   Rodrigues, António S ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Apoptosis; Gene expression; Leukaemia; Mitochondria; Myristicin

Indexed keywords

ATM PROTEIN; CASPASE 3; CYTOCHROME C; DNA; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; MYRISTICIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN GADD45A; PROTEIN GADD45G; RAD50 PROTEIN; RAD51 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ATM GENE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; ENZYME ACTIVATION; ERCC1 GENE; GADD45 ALPHA GENE; GADD45 GAMMA GENE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; K562 CELL LINE; LEUKEMIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; MRE11A GENE; NONHUMAN; NUTMEG; ONCOGENE; PROTEIN CLEAVAGE; PROTEIN SECRETION; RAD50 GENE; RAD51 GENE; SIGNAL TRANSDUCTION; XRCC3 GENE;

APOPTOSIS; GENE EXPRESSION; LEUKAEMIA; MITOCHONDRIA; MYRISTICIN;

APOPTOSIS; BENZYL COMPOUNDS; BLOTTING, WESTERN; CELL SURVIVAL; CYTOCHROMES C; DIOXOLANES; DNA DAMAGE; DNA FRAGMENTATION; DOWN-REGULATION; HUMANS; K562 CELLS; MITOCHONDRIA; MOLECULAR STRUCTURE; MYRISTICA FRAGRANS; POLYMERASE CHAIN REACTION; PYROGALLOL; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84900835398     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.04.014     Document Type: Article

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