Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease

Free Radical Biology and Medicine

Volumn 87, Issue , 2015, Pages 98-112

  Nilsson, M I ^a   Macneil, L G ^a   Kitaoka, Y ^a   Suri, R ^a   Young, S P ^b   Kaczor, J J ^c   Nates, N J ^a   Ansari, M U ^a   Wong, T ^a   Ahktar, M ^a   Brandt, L ^a   Hettinga, B P ^a   Tarnopolsky, M A ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Aging; Autophagy; Exocytosis; Lipofuscin; Lysosomal storage disorder; Neurodegenerative disease

Indexed keywords

CALCIUM ION; GLYCOGEN; LIPOFUSCIN; RECOMBINANT GLUCAN 1,4 ALPHA GLUCOSIDASE; TRANSCRIPTION FACTOR NRF2; ALPHA GLUCOSIDASE; HEAT SHOCK PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE;

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME REPLACEMENT; EXOCYTOSIS; GLYCOGEN STORAGE DISEASE TYPE 2; HUMAN; HUMAN TISSUE; LYSOSOME; MITOCHONDRION; MITOCHONDRION SWELLING; MONOTHERAPY; MOTOR PERFORMANCE; MOUSE; MUSCLE MASS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; DISEASE MODEL; EXERCISE; GENETICS; GLYCOGEN STORAGE DISEASE TYPE II; METABOLISM; PATHOLOGY;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALPHA-GLUCOSIDASES; ANIMALS; AUTOPHAGY; DISEASE MODELS, ANIMAL; ENZYME REPLACEMENT THERAPY; EXERCISE; GLYCOGEN STORAGE DISEASE TYPE II; HEAT-SHOCK PROTEINS; HUMANS; LYSOSOMES; MICE; MITOCHONDRIA;

EID: 84939191086     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.05.019     Document Type: Article

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